Occurrence and Behavior of Macrolide Antibiotics in Municipal Wastewater Treatment: Possible Importance of Metabolites, Synthesis Byproducts, and Transformation Products

Senta, Ivan; Kostanjevečki, Petra; Krizman-Matasic, Ivona; Terzić, Senka; Ahel, Marijan

doi:10.1021/acs.est.9b01420

Cited by 63 publications

(21 citation statements)

References 42 publications

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“…Recently, many hospitals and research facilities have been required to reduce the application of these medicines for several reasons. First, according to numerous studies, researchers confirmed these drugs have heavily leached into the environment in the past 20 years [74]. Secondly, the effluent from hospital wastewater has been regarded as the primary source for the spread of antiviral-and antibacterial-resistance genes [75].…”

Section: Antibiotic Groupsmentioning

confidence: 99%

Membrane bioreactors for hospital wastewater treatment: recent advancements in membranes and processes

Zhao

Qiu

Mamrol

et al. 2021

Front. Chem. Sci. Eng.

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Discharged hospital wastewater contains various pathogenic microorganisms, antibiotic groups, toxic organic compounds, radioactive elements, and ionic pollutants. These contaminants harm the environment and human health causing the spread of disease. Thus, effective treatment of hospital wastewater is an urgent task for sustainable development. Membranes, with controllable porous and nonporous structures, have been rapidly developed for molecular separations. In particular, membrane bioreactor (MBR) technology demonstrated high removal efficiency toward organic compounds and low waste sludge production. To further enhance the separation efficiency and achieve material recovery from hospital waste streams, novel concepts of MBRs and their applications are rapidly evolved through hybridizing novel membranes (non hydrophilic ultrafiltration/microfiltration) into the MBR units (hybrid MBRs) or the MBR as a pretreatment step and integrating other membrane processes as subsequent secondary purification step (integrated MBR-membrane systems). However, there is a lack of reviews on the latest advancement in MBR technologies for hospital wastewater treatment, and analysis on its major challenges and future trends. This review started with an overview of main pollutants in common hospital wastewater, followed by an understanding on the key performance indicators/criteria in MBR membranes (i.e., solute selectivity) and processes (e.g., fouling). Then, an in-depth analysis was provided into the recent development of hybrid MBR and integrated MBR-membrane system concepts, and applications correlated with wastewater sources, with a particular focus on hospital wastewaters. It is anticipated that this review will shed light on the knowledge gaps in the field, highlighting the potential contribution of hybrid MBRs and integrated MBRmembrane systems toward global epidemic prevention.

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Section: Antibiotic Groupsmentioning

confidence: 99%

Membrane bioreactors for hospital wastewater treatment: recent advancements in membranes and processes

Zhao

Qiu

Mamrol

et al. 2021

Front. Chem. Sci. Eng.

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“…Antibiotics from municipal sources require understanding of how antibiotics behave in wastewater treatment plants. A year‐long study performed by Senta, Kostanjevecki, Krizman‐Matasic, Terzic, and Ahel (2019) investigated the occurrence, behavior, and fate of macrolide antibiotics in a WWTP in Zagreb, Croatia. Particular emphasis was placed on detecting metabolites, synthesis by‐products, and transformation products of the target parent compounds.…”

Section: Antibiotics In Agroecosystemsmentioning

confidence: 99%

Detection, occurrence, and fate of emerging contaminants in agricultural environments (2020)

Snow

Cassada

Biswas

et al. 2020

Water Environment Research

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A review of 79 papers published in 2019 is presented. The topics ranged from detailed descriptions of analytical methods, to fate and occurrence studies, to ecological effects and sampling techniques for a wide variety of emerging contaminants likely to occur in agricultural environments. New methods and studies on veterinary pharmaceuticals, antibiotics, anthelmintics, and engineered nanomaterials in agricultural environments continue to expand our knowledge base on the occurrence and potential impacts of these compounds. This review is divided into the following sections: Introduction, Analytical Methods, Antibiotics in Agroecosystems, Pharmaceutical Fate and Occurrence, Anthelmintics and Engineered Nanomaterials.

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“…These six compounds were consisted of three new generation macrolides and three metabolites formed by deglycolysation. According to the study, they all have more or less toxicity to human's body [9]. The most frequent toxicity events of Telimycin were diarrhea and nausea including dizziness and vomit [10].…”

Section: F I G U R Ementioning

confidence: 99%

“…However, the peak width of neo spiramycin I became broader with the addition of ammonium acetate, and there were also two chromatographic peaks existed in oleandomycin. Therefore, in this experiment, a series of pH (3,4,5,6,7,8,9, and 10) gradients were selected to optimize the peak shapes of neo spiramycin I and oleandomycin. The results showed that the peak shape and peak resolution of each target were relatively good at pH ≤ 3 and pH ≥ 9.…”

Section: F I G U R Ementioning

confidence: 99%

Targeted analysis of six emerging derivatives or metabolites together with 25 common macrolides in milk using Quick, Easy, Cheap, Effective, Rugged and Safe extraction and ultra‐performance liquid chromatography quadrupole/electrostaticfield orbitrap mass spectrometry

Wang

Ling

Zhou

et al. 2020

J of Separation Science

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An analytical method for the determination of six emerging derivatives or metabolites together with 25 common macrolides antibiotics in milk by ultraperformance liquid chromatography quadrupole/electrostaticfield orbitrap mass spectrometry was established. The samples were purified with optimized Quick, Easy, Cheap, Effective, Rugged, Safe methods. The amounts of primarysecondary amine, C18, and sodium acetate adsorbent materials were optimized by response surface method to obtain the best purification effect. The chromatographic separation was carried out using the XBridge-C18 (2.1 × 100 mm, 3.5 µm, Waters) column with mobile phase of acetonitrile with 0.1% v/v formic acid-water solutions (containing 10 mmol/L ammonium acetate), separated by gradient elution. The instrument was operated in the detection mode of electrospray positive and negative ions with Full MS/data dependent MS 2 acquisition mode detection, external standard method was used for quantitative analysis. The limits of detection and limits of quantitation of 31 compounds were 0.1-0.5 µg/L and 0.5-2.0 µg/L, respectively. A total of 31 compounds performed a good linearity in the range of 1 to 200 µg/L, and the correlation coefficient was greater than 0.990. The spiked recoveries in milk samples were 81.07-110.1% and the relative standard deviation was less than 5.1%. The method was successful applied to actual sample testing in the market.

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Occurrence and Behavior of Macrolide Antibiotics in Municipal Wastewater Treatment: Possible Importance of Metabolites, Synthesis Byproducts, and Transformation Products

Cited by 63 publications

References 42 publications

Membrane bioreactors for hospital wastewater treatment: recent advancements in membranes and processes

Membrane bioreactors for hospital wastewater treatment: recent advancements in membranes and processes

Detection, occurrence, and fate of emerging contaminants in agricultural environments (2020)

Targeted analysis of six emerging derivatives or metabolites together with 25 common macrolides in milk using Quick, Easy, Cheap, Effective, Rugged and Safe extraction and ultra‐performance liquid chromatography quadrupole/electrostaticfield orbitrap mass spectrometry

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