Occurreimce of Lobo's Blasto Mycosis Among “Caiabi” Brazilian Indians

Baruzzi, Roberto Geraldo; Castro, R. M.; D'Andretta, Carlos; Carvalhal, S; Ramos, Oswaldo L.; Pontes, Paulo Lima

doi:10.1111/j.1365-4362.1973.tb00011.x

Cited by 19 publications

(22 citation statements)

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“…Thus, progression is theoretically more associated with activities related to the mechanism of infection rather than with genetic or specific hormonal factors. This finding is confirmed by the relatively higher frequency of Jorge Lobo's disease among women who cultivate the land in some Amazonian tribes [17,18]. On the other hand, there are no studies correlating the immune response to Jorge Lobo's disease with specific HLA loci, a fact supporting the importance of fungal ecology in the mechanism of transmission and, consequently, in the different incidence of the disease between men and women [4,5].…”

Section: Discussionsupporting

confidence: 52%

Macrophage and TGF-β immunohistochemical expression in Jorge Lobo's disease

et al. 2008

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Section: Discussionsupporting

confidence: 52%

Macrophage and TGF-β immunohistochemical expression in Jorge Lobo's disease

et al. 2008

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“…The persistence of environmental trigger such as heat or humidity might explain frequent recurrences. Conversely, no case of lobomycosis was described in our population, though this fungal infection has already been reported in French Guiana, 10,11 as in the Amerindian populations of Colombia 12 and Brazil 13 . The role of dolphins as hosts of Lacazia loboi has been recently discarded, 14 and its parasitic cycle remains unclear.…”

Section: Discussionmentioning

confidence: 52%

Spectrum of skin diseases in Amerindian villages of the Upper Oyapock, French Guiana

et al. 2020

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Background Due to their genetic characteristics, their isolation in rainforest areas, and their traditional way of life, Amerindian populations are likely to suffer from a specific spectrum of dermatoses. However, there are few available data on such skin disorders. Our aims were to describe all skin disorders in two Amerindian villages of French Guiana. Methods This retrospective study concerned all patients who consulted in the HealthCentres of Camopi and Trois-Sauts between July 1, 2017, and December 31, 2018. We included all patients classified with an ICD code linked to a skin disorder. All medical records were cross-checked by two dermatologists to correct misclassifications.Results A total of 639 patients formed the study population, for 866 different skin disorders. Non-sexually transmitted infections represented 57.6% of all skin disorders, followed by eczema (11.5%) and bites/envenomations (9.1%). Bacteria were responsible for 238 skin infections, followed by fungi (141 cases) and parasites (69 cases, including 43 scabies, nine cutaneous leishmaniasis, and two tungiasis). We reported a low prevalence of sexually transmitted infections (10 cases) and an absence of skin cancers. ConclusionsThis study revealed the absence of skin cancer in the Amerindian population of the Upper Oyapock and the important burden of infectious and animal-related diseases. Future studies should assess a possible underestimation of sexually transmitted diseases in this area. Public health policies should target neglected diseases such as cutaneous leishmaniasis, tungiasis, scabies, and envenomations. Atopic dermatitis was a significant and unexpected cause of consultations. Dermatological conditions in the Amerindian villages of French Guiana have never been described. About 12,000 Amerindians live in this territory, divided into six different ethnic groups. Many of them live in cities where ethnic diversity makes their study difficult, and the selection of patients according to ª

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“…Early on, an ethnic predominance to contract the infection has been suspected. The disproportionate number of cases in Amerindian inbred communities of Brazil 9,89–91 and the Casanare region 40 between Colombia and Venezuela once suggested the theory of genetic predisposition. However, the well documented observations done in the Cayabi Indian tribes (ethnic Mato Grosso group where over 60 cases were reported) revealed the absence of detection of new cases after members of this Ethnic group were relocated in other regions, implicating the environmental exposure as the predominating factor 9,40,89–91 …”

Section: Epidemiologymentioning

confidence: 99%

“…However, the well documented observations done in the Cayabi Indian tribes (ethnic Mato Grosso group where over 60 cases were reported) revealed the absence of detection of new cases after members of this Ethnic group were relocated in other regions, implicating the environmental exposure as the predominating factor. 9,40,[89][90][91] Most human cases described in the literature are linked to geographical regions with an important hydrographic component. In Brazil, all cases come from the Amazon region.…”

Section: Lobomycosis In Humans and Delphinidaementioning

confidence: 99%

Lobomycosis: an emerging disease in humans and delphinidae

Paniz-Mondolfi

Talhari

Hoffmann

et al. 2012

Mycoses

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Summary Lobomycosis, a disease caused by the uncultivable dimorphic onygenale fungi Lacazia loboi, remains to date as an enigmatic illness, both due to the impossibility of its aetiological agent to be cultured and grown in vitro, as well as because of its unresponsiveness to specific antifungal treatments. It was first described in the 1930s by Brazilian dermatologist Jorge Lobo and is known to cause cutaneous and subcutaneous localised and widespread infections in humans and dolphins. Soil and vegetation are believed to be the chief habitat of the fungus, however, increasing reports in marine mammals has shifted the attention to the aquatic environment. Infection in humans has also been associated with proximity to water, raising the hypothesis that L. loboi may be a hydrophilic microorganism that penetrates the skin by trauma. Although its occurrence was once thought to be restricted to New World tropical countries, its recent description in African patients has wrecked this belief. Antifungals noted to be effective in the empirical management of other cutaneous/subcutaneous mycoses have proven unsuccessful and unfortunately, no satisfactory therapeutic approach for this cutaneous infection currently exists.

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Occurreimce of Lobo's Blasto Mycosis Among “Caiabi” Brazilian Indians

Cited by 19 publications

References 0 publications

Macrophage and TGF-β immunohistochemical expression in Jorge Lobo's disease

Macrophage and TGF-β immunohistochemical expression in Jorge Lobo's disease

Spectrum of skin diseases in Amerindian villages of the Upper Oyapock, French Guiana

Lobomycosis: an emerging disease in humans and delphinidae

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