Occupations at risk of developing contact allergy to isothiazolinones in Danish contact dermatitis patients: results from a Danish multicentre study (2009–2012)

Abstract

Several high-risk occupations for sensitization to isothiazolinones exist. Regulation on the allowed concentration of isothiazolinones, and especially MI, in both consumer products and industrial products is needed.

Prevalence of methylchloroisothiazolinone and methylisothiazolinone contact allergy in facial dermatitis: a single centre Irish study

“…They were mainly women with a median age of 49 years were affected with hand and/or facial dermatitis, most often resulting from the use of cosmetics . A recent Danish study by Schwensen et al . found a significant increased prevalence in MI contact allergy from 1.8% in 2009 to 4.2% in 2012.…”

Cross‐reactivity between methylisothiazolinone, octylisothiazolinone and benzisothiazolinone using a modified local lymph node assay

“…in the 1980s, using the guinea pig maximization test . Interestingly, several observational studies have described potential cross‐reactivity between selected isothiazolinones, but it is currently unknown to what extent cross‐reactivity exists in patients with MI contact allergy …”

Isothiazolinone derivatives and allergic contact dermatitis: a review and update

“…reported that 16.8% of patients with relevant MI contact allergy were exposed to occupational products containing MCI/MI or MI, the risk being highest for those who directly handle isothiazolinones . Painters, machinists, glass makers, cosmetologists, hairdressers, beauticians, mechanics and repairmen have likewise been concerned . In Finland, a sixfold increase in occupational contact dermatitis from MI and MCI/MI was noted in 2015 .…”