Occupations and industries in France at high risk for pleural mesothelioma: A population‐based case–control study (1998–2002)

Rolland, Patrick; Gramond, Céline; Lacourt, Aude; Astoul, Philippe; Chamming’s, Soizick; Ducamp, Stéphane; Frenay, C.; Galateau-Sallé, Françoise; Ilg, Anabelle Gilg Soit; Imbernon, Ellen; Stang, Nolwenn Le; Pairon, J.-C.; Goldberg, Marcel; Brochard, Patrick

doi:10.1002/ajim.20895

Cited by 48 publications

(42 citation statements)

References 31 publications

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“…These data are consistent with the meta-analysis of epidemiologic studies that investigated the incidence of lung cancer and pleural mesothelioma in automobile mechanics and failed to demonstrate increased metarelative risks (Wong, 2001;Goodman et al, 2004). Our data are also consistent with the results of a recently published population-based case-control study (Rolland et al, 2010) that reported a slight but not significant increased risk of pleural mesothelioma in male car mechanics (odds ratio 5 1.50; 95% confidence interval: 0.76-2.95).…”

Section: Discussionsupporting

confidence: 82%

Asbestos-Related Diseases in Automobile Mechanics

Ameille

Rosenberg

Matrat

et al. 2011

The Annals of Occupational Hygiene

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Purpose: Automobile mechanics have been exposed to asbestos in the past, mainly due to the presence of chrysotile asbestos in brakes and clutches. Despite the large number of automobile mechanics, little is known about the non-malignant respiratory diseases observed in this population. The aim of this retrospective multicenter study was to analyse the frequency of pleural and parenchymal abnormalities on high-resolution computed tomography (HRCT) in a population of automobile mechanics.Methods: The study population consisted of 103 automobile mechanics with no other source of occupational exposure to asbestos, referred to three occupational health departments in the Paris area for systematic screening of asbestos-related diseases. All subjects were examined by HRCT and all images were reviewed separately by two independent readers; who in the case of disagreement discussed until they reached agreement. Multiple logistic regression models were constructed to investigate factors associated with pleural plaques.Results: Pleural plaques were observed in five cases (4.9%) and interstitial abnormalities consistent with asbestosis were observed in one case. After adjustment for age, smoking status, and a history of non-asbestos-related respiratory diseases, multiple logistic regression models showed a significant association between the duration of exposure to asbestos and pleural plaques.Conclusions: The asbestos exposure experienced by automobile mechanics may lead to pleural plaques. The low prevalence of non-malignant asbestos-related diseases, using a very sensitive diagnostic tool, is in favor of a low cumulative exposure to asbestos in this population of workers.

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Section: Discussionsupporting

confidence: 82%

Asbestos-Related Diseases in Automobile Mechanics

Ameille

Rosenberg

Matrat

et al. 2011

The Annals of Occupational Hygiene

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“…The study design was previously reported in detail 18. Cases were identified through the PNSM from 1998 to 2002 and certified by a standardised diagnostic confirmation procedure 17.…”

Section: Methodsmentioning

confidence: 99%

Occupational and non-occupational attributable risk of asbestos exposure for malignant pleural mesothelioma

Lacourt¹,

Gramond

Rolland

et al. 2014

Thorax

128

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“…The patient was asymptomatic and the physical examination was unremarkable. A chest CT scan was performed, according to the French Recommendations for Workers with Known Asbestos Exposure; this demonstrated pleural thickenings [11]. …”

Section: Case Reportsmentioning

confidence: 99%

Positive FDG-PET/CT of the Pleura Twenty Years after Talc Pleurodesis: Three Cases of Benign Talcoma

Vandemoortele

Laroumagne

Roca³

et al. 2014

Respiration

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The FDG-PET (fluorine-18 fluorodeoxyglucose positron emission tomography) scan is used with increasing frequency to investigate pleural abnormalities and to determine the possibility of neoplastic invasion. However, false-positive findings are not uncommon and talc pleurodesis has been reported to cause hypermetabolic pleural thickenings up to 5 years after the procedure. We report the cases of 3 patients (2 of whom had a history of asbestos exposure) requiring talc pleurodesis for recurrent pneumothoraces between 1988 and 1990, who were investigated in 2011 for pleural abnormalities. Avid pleural thickening on FDG-PET scan mimicking pleural cancer was found, but this was deemed secondary to the pleurodesis. Talc pleurodesis generates inflammation which promotes pleural adhesions. This inflammatory reaction could decrease with time, as in other inflammatory processes. Since talc is not metabolized by the body, the FDG-PET scan can remain positive, most likely because of a foreign-body granulomatous reaction, even 20 years later. It is important to be aware of this possibility and to question patients with pleural abnormalities about past procedures and mention such procedures to the colleagues who are responsible for interpreting metabolic imaging. Follow-up of hypermetabolic pleural lesions attributed to talc pleurodesis is important for the detection of new pleural lesions or neoplastic evolution.

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Occupations and industries in France at high risk for pleural mesothelioma: A population‐based case–control study (1998–2002)

Cited by 48 publications

References 31 publications

Asbestos-Related Diseases in Automobile Mechanics

Asbestos-Related Diseases in Automobile Mechanics

Occupational and non-occupational attributable risk of asbestos exposure for malignant pleural mesothelioma

Positive FDG-PET/CT of the Pleura Twenty Years after Talc Pleurodesis: Three Cases of Benign Talcoma

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