Occupationally induced fixed drug eruption caused by a non‐steroidal anti‐inflammatory agent

Probable cutaneous adverse drug reaction to piroxicam in a cat

“…6 NSAIDs have been previously shown to cause cutaneous ADRs in both dogs and people. [7][8][9][10][11][12][13][14][15][16][17][18][19][20] Carprofen and firocoxib have been associated with skin eruptions resembling Sweet's syndrome in four dogs. [8][9][10] Carprofen has also been associated with toxic epidermal necrolysis in a dog.…”

“…12 In people, reports of cutaneous reactions to piroxicam include photosensitivity, urticaria, erythema multiforme, toxic epidermal necrolysis, pemphigus vulgaris, fixed drug eruption, drug rash with eosinophilia and systemic symptoms (DRESS syndrome), and acute generalized pustulosis. [13][14][15][16][17][18] Most cases resolved rapidly following discontinuation of piroxicam. [13][14][15][16][17][18] ADRs from NSAIDs are thought to be caused by a hypersensitivity reaction, which can be classified as either cross-reactive among chemically unrelated NSAIDs or selective to a specific NSAID.…”

“…[13][14][15][16][17][18] Most cases resolved rapidly following discontinuation of piroxicam. [13][14][15][16][17][18] ADRs from NSAIDs are thought to be caused by a hypersensitivity reaction, which can be classified as either cross-reactive among chemically unrelated NSAIDs or selective to a specific NSAID. 19,20 Cross-reactive reactions occur through non-immunological mechanisms related to arachidonic acid metabolism.…”