Occupational UV-Exposure is a Major Risk Factor for Basal Cell Carcinoma

Abstract

Skin cancer prevention strategies should be expanded to the occupational setting.

Different outdoor professions have different risks – a cross‐sectional study comparing non‐melanoma skin cancer risk among farmers, gardeners and mountain guides

“…In this study, the overall NMSC prevalence in outdoor workers was higher compared to indoor workers as expected and previously published. [6][7][8][9]11,15,30 The point prevalence of NMSC in police mountain guides in this study (33.3%) is comparable to NMSC rates of 33.9% 21 and 43.5% 22 in state-certified mountain guides published in 2010 and 2016, respectively. The point prevalence of NMSC in farmers (27.4%) and gardeners (19.5%) overall seems to be in line with the literature, 16,32,33 although exact reference values could not be found.…”

“…5,6 Other NMSC forms such as basal cell carcinoma (BCC) and merkel cell carcinoma are not included, although there is some evidence, that UV exposure might play a role in the pathogenesis of both. 3,8,9 Especially for BCC, UVR might be crucial for the development of some BCC subtypes with typical UV-induced DNA damage signatures. 3,10 Despite all the evidence of UVR as a main risk factor for NMSC, 3,11 there are still some open questions.…”

Skin cancer in outdoor workers exposed to solar radiation: a largely underreported occupational disease in Italy

“…On the contrary, the estimated number of expected occupational NMSC possibly will be lower than the real number. In fact, occupational sUVR is the main risk factor for NMSC in workers, and according to recent studies of Schmitt et al 23,24 the risk in exposed workers is probably between 1.5 and 2.5 compared with the non-exposed; as we have applied to the outdoor workers the incidence rates of the general population, an overestimation of the incidence is unlikely. Furthermore, the number of exposed workers was derived from the CAREX database, but recent studies on sUVR occupational exposure suggest a high exposure in the large majority of the outdoor workers 3 that exceeds the numbers proposed by CAREX; accordingly, again an overestimation of the number of exposed workers seems highly unlikely.…”

“…18 In another study, performed in Trentino region, Northern Italy, Boi et al calculated a standardized annual incidence of 61.5 per 100 000 (CI 58.5-64.5) for BCC and of 16.3 per 100 000 (CI 14.9-17.7) for SCC, 19 but it has also to be considered that, in Northern Italy, the prevalence of NMSC is lower than in the south, and that, according to some studies, the incidence of these cancers is constantly increasing. 20,21 Epidemiologically, the causal relation between occupational sUVR exposure and NMSC is now firmly established; 10,11,[22][23][24] however, only a few European countries recognize these cancers as occupational diseases. 12,22 In Italy, NMSC, and also actinic keratosis (AK), are included in the list of occupational diseases that can be compensated in workers exposed to UVR and to sUVR by the Italian Workers' Compensation Authority (Istituto Nazionale per l'Assicurazione contro gli Infortuni sul Lavoro -INAIL), while MM is not included in that list.…”

Мікрографічна Хірургія За Мосом Для Лікування Базальноклітинних Карцином Високого Ступеня Ризику

“…Эпидемиологические данные подчеркивают ведущую роль ультрафиолетового (УФ) излучения в развитии БКК у лиц с генетической предрасположенностью (светлый фототип кожи), наличием генетических заболеваний (синдром Горлина -Гольца, пигментная ксеродерма) [6,7]. Люди, проживающие в зонах с повышенным уровнем инсоляции, представители профессий, связанных с длительным пребыванием на солнце (строители, фермеры), а также любители загара и рекреационной активности на открытом воздухе имеют значительно больший риск заболеть БКК в течение жизни [8].…”