Occupational tuberculosis following extremely short exposure

Kamper-Jørgensen, Zaza; Lillebæk, Troels; Andersen, Åse Bengård

doi:10.1111/j.1752-699x.2008.00074.x

Cited by 4 publications

(4 citation statements)

References 11 publications

(14 reference statements)

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“…As for the extrapulmonary tuberculosis in our study; lymph node involvement (19.2%) is the most common presentatin followed by the pleura (8.3%) and bone (4%). Previous studies reported the extrapulmonary tuberculosis rate in different populations [13,[17][18][19][20]. Compared with them, extrapulmonary tuberculosis rate was higher in our study population.…”

Section: Discussioncontrasting

confidence: 52%

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Clinical presentation of tuberculosis: a nine-year single-center experience

Ekiz

Abakay

2018

The European Research Journal

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Objective. The aim of this study was to determine the clinical presentation of tuberculosis cases from our center for the last nine years. Methods. This study was set as descriptive and retrospective. The data was obtained from the hospital records. Subjects who had been diagnosed as tuberculosis and received treatment in our center between the years 2007 and 2015 were included. The cases were classified as newly diagnosed, relapse, transferred, and returning after default. Results. There were 276 (171 males and 105 females) patients with a mean age of 41.5 ± 19.2 years. Pulmonary involvement is the most common presentation and seen in 155 (56.2%) patients. Lymph node and pleura are the most common extrapulmonary involvements those are seen in 53 (19.2%) and 23 (8.3%) patients, respectively. Number of the cases seems to decreased after 2012. Most (85.1%) of the patients were newly diagnosed. Among the subjects, 55.2% of them had bacteriologic diagnosis, 35.1% had histopathologic diagnosis. Two subjects died during the treatment period whereas 274 of them completed the treatment program. Conclusions. Our results show that tuberculosis is seen mainly in the adult age group. While pulmonary involvement is the most common presentation, lymph node and pleura involvements are the most common extrapulmonary presentations. Number of the tuberculosis seems to decrease for the recent years. Strict preventive measures and treatment strategies should be administered.

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Section: Discussioncontrasting

confidence: 52%

“…Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Although tuberculosis primarily involves the lungs, any sort of extrapulmonary involvements can be seen [8][9][10][11][12][13]. Recording, analysis, and reporting the tuberculosis cases is the mainstay of the tuberculosis control program according to the WHO.…”

Section: Discussionmentioning

confidence: 99%

Clinical presentation of tuberculosis: a nine-year single-center experience

Ekiz

Abakay

2018

The European Research Journal

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“…Only sporadic information was available on the duration of exposure for the cases in our study. However, one of the confirmed cases of occupational TB transmission was seen after extremely short exposure; this case has previously been reported by Kamper-Jørgensen et al [ 20 ]. This underscores the additional role genotyping has in contact tracing as conventional methods for this case would most likely have pointed on other more obvious potential links in which duration of exposure was longer.…”

Section: Discussionsupporting

confidence: 55%

Occupational Tuberculosis in Denmark through 21 Years Analysed by Nationwide Genotyping

Pedersen

Andersen

et al. 2016

PLoS ONE

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Tuberculosis (TB) is a well-known occupational hazard. Based on more than two decades (1992–2012) of centralized nationwide genotyping of all Mycobacterium tuberculosis culture-positive TB patients in Denmark, we compared M. tuberculosis genotypes from all cases notified as presumed occupational (N = 130) with M. tuberculosis genotypes from all TB cases present in the country (N = 7,127). From 1992 through 2006, the IS6110 Restriction Fragment Length Polymorphism (RFLP) method was used for genotyping, whereas from 2005 to present, the 24-locus-based Mycobacterial Interspersed Repetitive Unit-Variable Number of Tandem Repeat (MIRU-VNTR) was used. An occupational TB case was classified as clustered if the genotype was 100% identical to at least one other genotype. Subsequently, based on genotype, time period, smear positivity, geography, susceptibility pattern, and any reported epidemiological links between the occupational cases and any potential source cases, the occupational case was categorized as confirmed, likely, possible or unlikely occupationally infected. Among the 130 notified presumed occupational cases, 12 (9.2%) could be classified as confirmed and 46 (35.4%) as unlikely, accounting for nearly half of all cases (44.6%). The remaining 72 cases (55.4%) were categorized as possible. Within this group, 15 cases (11.5%) were assessed to be likely occupational. Our study shows that genotyping can serve as an important tool for disentangle occupational TB in high-income low incidence settings, but still needs to be combined with good epidemiological linkage information.

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“…In the meantime, K amper- J ørgensen et al . [ 20 ] reported M. tuberculosis transmission from a patient to a nurse following an extremely short exposure by retrospective evaluation of the Danish TB Subtyping Database, comprising >6000 DNA patterns from TB patients nationwide. N odieva et al .…”

Section: Discussionmentioning

confidence: 99%

Risk of tuberculosis transmission among healthcare workers

2018

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Data from a prospective molecular-epidemiological study (1997–2015) of patients with culture-confirmed tuberculosis in Hamburg, Germany, were evaluated to assess the occupational risk of Mycobacterium tuberculosis complex transmission in a low-incidence setting.Isolates of M. tuberculosis complex were genotyped using IS6110 restriction fragment length polymorphism analysis. Results of structured questionnaires, geographical mapping and additional patient interviews were used for confirming epidemiological links.Out of the 2393 cases, 918 (38.4%) were classified into 224 clusters comprising 2–70 patients per cluster. Among the 918 cluster members, epidemiological links could be confirmed in 340 (37.0%) patients. In total, 55 (2.3%) patients were healthcare workers; 26 healthcare workers remained unclustered, but 29 healthcare workers belonged to cluster groups. Conventional contact tracing performed before genotyping to identify sources of the reported index cases detected only 73 (3.1%) patients.Logistic regression analysis confirmed work in the healthcare sector as strongest predictor for clustering of patients with verified epidemiological links (odds ratio (OR) 3.1, 95% CI 1.6–5.9), followed by alcoholism (OR 2.3, 95% CI 1.7–3.2) and sputum smear positivity (OR 1.8, 95% CI 1.4–2.3). Immigrants were more likely to be cluster nonmembers (OR 0.3, 95% CI 0.3–0.5). Recent transmission in Hamburg within the 19-year study period was found to be strongly associated with working in a healthcare facility. Although clusters also include many “imported” strains from abroad or regional highly prevalent M. tuberculosis strains with no evident epidemiological connection, routine molecular-epidemiological survey is indispensable to optimising and controlling the effectiveness of TB control strategies in German healthcare settings.

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Occupational tuberculosis following extremely short exposure

Cited by 4 publications

References 11 publications

Clinical presentation of tuberculosis: a nine-year single-center experience

Clinical presentation of tuberculosis: a nine-year single-center experience

Occupational Tuberculosis in Denmark through 21 Years Analysed by Nationwide Genotyping

Risk of tuberculosis transmission among healthcare workers

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