Occupational trichloroethylene hypersensitivity syndrome: Human herpesvirus 6 reactivation and rash phenotypes

Kamijima, Michihiro; Wang, Hailan; Yamanoshita, Osamu; Ito, Yuki; Xia, Lihua; Yanagiba, Yukie; Chen, Cishan; Okamura, Ai; Huang, Zhenlie; Qiu, Xinxiang; Song, Xiaolu; Cai, Tingfeng; Liu, Huan; Ge, Yichen; Deng, Yingyu; Naito, Hisao; Yoshikawa, Tetsushi; Tohyama, Mikiko; Li, Laiyu; Huang, Hanlin; Nakajima, Tamie

doi:10.1016/j.jdermsci.2013.07.003

Cited by 33 publications

(31 citation statements)

References 36 publications

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“…Descamps et al reported high concentrations of anti-HHV six immunoglobulin (Ig) G and M and HHV-6 DNA copies in the serum of five patients with DRESS due to CBZ, supporting some association with DRESS [58]. Kamijima et al reported that reactivated HHV-6 and the increased cytokines could be biomarkers of trichloroethylene hypersensitivity syndrome [59].…”

Section: Discussionmentioning

confidence: 99%

Lamotrigine induced DIHS/DRESS: Manifestations, treatment, and outcome in 57 patients

Wang

et al. 2015

Clinical Neurology and Neurosurgery

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Section: Discussionmentioning

confidence: 99%

Lamotrigine induced DIHS/DRESS: Manifestations, treatment, and outcome in 57 patients

Wang

et al. 2015

Clinical Neurology and Neurosurgery

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“…Based on the associated clinical features, frequent relapse, low incidence but high mortality, THS has become an important occupational health issue in Asia. Over the last 20 years, worldwide studies on the etiology, pathogenesis, occupational epidemiology and countermeasures of THS have been published [ 2 , 4 – 8 ]. Studies on patients with THS have indicated that it is an occupational immunological disease, with a latency extending from 5 to 40 days, but no longer than 80 days [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Trichloroethylene Hypersensitivity Syndrome Is Potentially Mediated through Its Metabolite Chloral Hydrate

Huang

Xia²,

Wu³

et al. 2015

PLoS ONE

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BackgroundWe documented previously the entity of trichloroethylene (TCE) hypersensitivity syndrome (THS) in occupational workers.ObjectivesTo identify the culprit causative compound, determine the type of hypersensitivity of THS, and establish a screening test for subjects at risk of THS.MethodsTCE and its main metabolites chloral hydrate (CH), trichloroethanol (TCOH) and trichloroacetic acid (TCA) were used as allergens at different concentrations in skin patch tests. The study included 19 case subjects diagnosed with occupational THS, 22 control healthy workers exposed to TCE (exposure >12 weeks), and 20 validation new workers exposed to TCE for <12 weeks free of THS. All subjects were followed-up for 12 weeks after the patch test.ResultsThe highest patch test positive rate in subjects with THS was for CH, followed by TCOH, TCA and TCE. The CH patch test positive rate was 100% irrespective of CH concentrations (15%, 10% and 5%). The TCOH patch test positive rate was concentration-dependent (89.5%, 73.7% and 52.6% for 5%, 0.5% and 0.05%, respectively). Lower patch test positive rates were noted for TCA and TCE. All patch tests (including four allergens) were all negative in each of the 22 control subjects. None of the subjects of the validation group had a positive 15% CH patch test.ConclusionsChloral hydrate seems to be the culprit causative compound of THS and type IV seems to be the major type of hypersensitivity of THS. The CH patch test could be potentially useful for screening workers at risk of THS.

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“…Interestingly, several studies have proposed that herpesvirus and cytomegalovirus are reactivated in a considerable proportion of the ODMLT cases with liver damage. Furthermore, the antibody titer against virus was significantly higher in the patients (Kamijima et al, 2013;Watanabe et al, 2010).…”

Section: Introductionmentioning

confidence: 91%

“…On day 9 17 and 19, 30% TCE (TCE: acetone: olive oil= 3:5:2) was applied as the first and second challenge, respectively. Viral infection is closely associated with TCE-induced hypersensitivity syndrome (Kamijima et al, 2013;Watanabe et al, 2010;Xu et al, 2009), and this infection was mimicked by poly(I:C) injection, which is widely used as a simulation of viral infection in animal model (Cheng et al, 2009). In poly(I:C) and TCE cotreatment group, another 80 mice were randomly assigned into four subgroups of different time points (n = 20 for each subgroup) followed by the same treatment.…”

Section: Treatments Of Animalsmentioning

confidence: 99%

Viral mimic polyinosine-polycytidylic acid potentiates liver injury in trichloroethylene-sensitized mice – Viral-chemical interaction as a novel mechanism

Zhang

et al. 2018

Ecotoxicology and Environmental Safety

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Occupational trichloroethylene hypersensitivity syndrome: Human herpesvirus 6 reactivation and rash phenotypes

Cited by 33 publications

References 36 publications

Lamotrigine induced DIHS/DRESS: Manifestations, treatment, and outcome in 57 patients

Lamotrigine induced DIHS/DRESS: Manifestations, treatment, and outcome in 57 patients

Trichloroethylene Hypersensitivity Syndrome Is Potentially Mediated through Its Metabolite Chloral Hydrate

Viral mimic polyinosine-polycytidylic acid potentiates liver injury in trichloroethylene-sensitized mice – Viral-chemical interaction as a novel mechanism

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