Occupational risks for adenocarcinoma of the nasal cavity and paranasal sinuses in the German wood industry

Pesch, Beate; Pierl, Christiane Barbara; Gebel, Martin; Groß, Isabelle; Becker, Doreen; Johnen, Georg; Rihs, Hans‐Peter; Donhuijsen, K; Lepentsiotis, Vasilios; Meier, Martin; Schulze, Johannes; Brüning, Thomas

doi:10.1136/oem.2007.033886

Cited by 31 publications

(19 citation statements)

References 16 publications

(13 reference statements)

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“…It has already been shown that wood dusts, particularly that from hardwoods, have a carcinogenic potential (HadWeld and Macbeth 1971;Kleinsasser and Schroeder 1988;Pesch et al 2008). The proportion of primary woodworking occupations is higher in other European studies (Leclerc et al 1994;Bimbi et al 2004) than ours.…”

Section: Discussionmentioning

confidence: 66%

“…However, it has been shown that patients suVering from adenocarcinoma working in a primary woodworking occupation had frequently additional contact with formaldehyde-containing chipboards, as well. Although there is virtually no valid technical data on formaldehyde exposure, an overall increased risk of adenocarcinoma through formaldehyde in the wood industry appears to be conceivable (Luce et al 2002;Pesch et al 2008).…”

Section: Discussionmentioning

confidence: 97%

“…Sinonasal adenocarcinoma of the intestinal type has been recognised in Germany as an occupational disease (BK 4203) when relevant exposure to known harmful substances at workplace is or has been present. The average exposure time to hazardous wood dust is assumed to be 25.6 years (Lietin et al 2006;Pesch et al 2008), with critical latencies (deWned as time span between date of Wrst exposure to hazardous wood dust and diagnosis of adenocarcinoma) of 36.6 years (Caroyer and Van Dessel 1987) to 44.7 years (Acheson et al 1968;Andersen et al 1977;Engzell 1979;Kleinsasser and Schroeder 1988). This indicates that aVected persons are often retired at the time of diagnosis.…”

Section: Introductionmentioning

confidence: 99%

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Characterization of initial clinical symptoms and risk factors for sinonasal adenocarcinomas: results of a case–control study

Mayr

Hafizovic

Waldfahrer

et al. 2009

Int Arch Occup Environ Health

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Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Characterization of initial clinical symptoms and risk factors for sinonasal adenocarcinomas: results of a case–control study

Mayr

Hafizovic

Waldfahrer

et al. 2009

Int Arch Occup Environ Health

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“…The epidemiological studies published by the IARC after 1995 have shown contradictory evidence on carcinogenicity and occupational exposure to wood dust 4,7–11. Several paradoxical findings have offered opportunities for new studies to recapitulate the plausible carcinogenicity with stronger evidence, such as a much greater risk by exposure to softwood dust suggested in northern Europe than in North America,12 the conflicting dose-response pattern (strong link between nasopharyngeal cancer with low intensity and a short-duration exposure),6,9 and the uncommon evidence in lung cancer 4,13.…”

Section: Introductionmentioning

confidence: 99%

Occupational exposure to wood dust and formaldehyde and risk of nasal, nasopharyngeal, and lung cancer among Finnish men

Siew¹,

Kauppinen²,

Kyyrönen³

et al. 2012

CMAR

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Controversy exists over whether or not occupational inhalation exposure to wood dust and/or formaldehyde increases risk for respiratory cancers. The objective of this study was to examine the risk of nasal, nasopharyngeal, and lung cancer in relation to occupational exposure to wood dust and formaldehyde among Finnish men. The cohort of all Finnish men born between the years 1906 and 1945 and in employment during 1970 was followed up through the Finnish Cancer Registry for cases of cancers of the nose (n = 292), nasopharynx (n = 149), and lung (n = 30,137) during the period 1971–1995. The subjects’ occupations, as recorded in the population census in 1970, were converted to estimates of exposure to wood dust, formaldehyde, asbestos, and silica dust through the Finnish job-exposure matrix. Cumulative exposure (CE) was calculated based on the prevalence, average level, and estimated duration of exposure. The relative risk (RR) estimates for the CE categories of wood dust and formaldehyde were defined by Poisson regression, with adjustments made for smoking, socioeconomic status, and exposure to asbestos and/or silica dust. Men exposed to wood dust had a significant excess risk of nasal cancer overall (RR, 1.59; 95% confidence interval [CI], 1.06–2.38), and specifically nasal squamous cell carcinoma (RR, 1.98; 95% CI, 1.19–3.31). Workers exposed to formaldehyde had an RR of 1.18 (95% CI, 1.12–1.25) for lung cancer. There was no indication that CE to wood dust or formaldehyde would increase the risk of nasopharyngeal cancer. Occupational exposure to wood dust appeared to increase the risk of nasal cancer but not of nasopharyngeal or lung cancer. The slight excess risk of lung cancer observed for exposure to formaldehyde may be the result of residual confounding from smoking. In summary, this study provides further evidence that exposure to wood dust in a variety of occupations may increase the risk of nasal cancer.

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“…This cancer is recognized as an occupational cancer. In fact, it is well confirmed today that sinonasal adenocarcinoma is highly correlated with duration and level (3.5 mg/m 3 ) of wood dust exposure [3,4]. As such, woodworkers have very high risks of nasal cancer (Standard Mortality Ratio: 310, 95% CI, 160-560) [5,6].…”

Section: Introductionmentioning

confidence: 99%

Gene expression profiling in sinonasal adenocarcinoma

et al. 2009

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BackgroundSinonasal adenocarcinomas are uncommon tumors which develop in the ethmoid sinus after exposure to wood dust. Although the etiology of these tumors is well defined, very little is known about their molecular basis and no diagnostic tool exists for their early detection in high-risk workers.MethodsTo identify genes involved in this disease, we performed gene expression profiling using cancer-dedicated microarrays, on nine matched samples of sinonasal adenocarcinomas and non-tumor sinusal tissue. Microarray results were validated by quantitative RT-PCR and immunohistochemistry on two additional sets of tumors.ResultsAmong the genes with significant differential expression we selected LGALS4, ACS5, CLU, SRI and CCT5 for further exploration. The overexpression of LGALS4, ACS5, SRI, CCT5 and the downregulation of CLU were confirmed by quantitative RT-PCR. Immunohistochemistry was performed for LGALS4 (Galectin 4), ACS5 (Acyl-CoA synthetase) and CLU (Clusterin) proteins: LGALS4 was highly up-regulated, particularly in the most differentiated tumors, while CLU was lost in all tumors. The expression of ACS5, was more heterogeneous and no correlation was observed with the tumor type.ConclusionWithin our microarray study in sinonasal adenocarcinoma we identified two proteins, LGALS4 and CLU, that were significantly differentially expressed in tumors compared to normal tissue. A further evaluation on a new set of tissues, including precancerous stages and low grade tumors, is necessary to evaluate the possibility of using them as diagnostic markers.

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Occupational risks for adenocarcinoma of the nasal cavity and paranasal sinuses in the German wood industry

Cited by 31 publications

References 16 publications

Characterization of initial clinical symptoms and risk factors for sinonasal adenocarcinomas: results of a case–control study

Characterization of initial clinical symptoms and risk factors for sinonasal adenocarcinomas: results of a case–control study

Occupational exposure to wood dust and formaldehyde and risk of nasal, nasopharyngeal, and lung cancer among Finnish men

Gene expression profiling in sinonasal adenocarcinoma

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