Occupational risk factors for sinonasal inverted papilloma: a case–control study

d’Errico, Angelo; Zajacovà, Jana; Cacciatore, Anna Maria; Baratti, Alberto; Zanelli, R.; Alfonzo, Santo; Beatrice, Fabio

doi:10.1136/oemed-2013-101384

Cited by 36 publications

(34 citation statements)

References 17 publications

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“…A possible role of CS exposure in sinonasal cancer has also been discussed ('t Mannetje et al, 1999;Kuper et al, 2002;Sham et al, 2010;Moon et al, 2010;d'Errico et al, 2013). Alterations of gene expression in nasal epithelial cells attributed to smoking resemble those in lower airway epithelial cells (Sridhar et al, 2008), although some differences exist (Huvenne et al, 2010).…”

Section: R4f Smoke and Ths22 Aerosol Exposure And Endpoint Generationmentioning

confidence: 99%

3-D nasal cultures: Systems toxicological assessment of a candidate modified-risk tobacco product

Iskandar

Mathis

Martin

et al. 2017

ALTEX

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ratory animals -to reduce the number of animals, to refine the design of procedures such that pain and distress are minimized, and to replace animal models with alternative methods and lower organisms when possible (Doke and Dhawale, 2015). In this regard, the capability to preserve human respiratory cells in culture provides a tool not only to generate mechanistic data, but also to improve the predicted effects of exposure hazard through inhalation in humans. An emphasis on assessment studies using human-derived in vitro culture systems will reduce the problems that are inherent to interspecies translatability (Manuppello and Sullivan, 2015).In vitro toxicology approaches have evolved from focusing on the molecular changes within a cell to understanding the toxicity-related mechanisms (cell-cell interactions) in models IntroductionMechanistic investigation of the impact of exposure on the lower airway remains challenging because access to lung tissues is limited. Although biopsy samples can be obtained from patients/donors for mechanistic studies of exposure-induced injury, a biopsy procedure is invasive and there are related ethical concerns (Peppercorn, 2013). Alternatively, animal studies allow the collection of biological samples from various animal models of human diseases. However, biological responses can vary among animal species, and findings obtained from animal studies may not apply to humans. Alternatives to animal testing have been proposed to overcome these drawbacks, including the 3Rs strategy -reduction, refinement, and replacement of labo- Research SummaryIn vitro toxicology approaches have evolved from a focus on molecular changes within a cell to understanding of toxicity-related mechanisms in systems that can mimic the in vivo environment. The recent development of three dimensional (3-D) organotypic nasal epithelial culture models offers a physiologically robust system for studying the effects of exposure through inhalation. Exposure to cigarette smoke (CS) is associated with nasal inflammation; thus, the nasal epithelium is relevant for evaluating the pathophysiological impact of CS exposure. The present study investigated further the application of in vitro human 3-D nasal epithelial culture models for toxicological assessment of inhalation exposure. Aligned with 3Rs strategy, this study aimed to explore the relevance of a human 3-D nasal culture model to assess the toxicological impact of aerosols generated from a candidate modified risk tobacco product (cMRTP), the Tobacco Heating System (THS) 2.2, as compared with smoke generated from reference cigarette 3R4F. A series of experimental repetitions, where multiple concentrations of THS2.2 aerosol and 3R4F smoke were applied, were conducted to obtain reproducible measurements to understand the cellular/molecular changes that occur following exposure. In agreement with "Toxicity Testing in the 21 st Century -a Vision and a Strategy", this study implemented a systems toxicology approach and found that for all tested concentrations the impa...

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Section: R4f Smoke and Ths22 Aerosol Exposure And Endpoint Generationmentioning

confidence: 99%

3-D nasal cultures: Systems toxicological assessment of a candidate modified-risk tobacco product

Iskandar

Mathis

Martin

et al. 2017

ALTEX

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“…The etiology of SNIP is unknown but different etiologic hypotheses have been made including viral infection (HPV), chronic inflammation, environmental pollution and occupational exposure (welding fumes, nickel compounds and organic solvents) [3]. It is very likely that an industrial occupational exposure may be an important risk factor; a recent study revealed a significant relationship between occupational exposure to organic solvents and SNIP [4]. SNIP generally originates from the lateral nasal wall, ethmoid sinus, maxillary sinus, and, less commonly, from the frontal and sphenoid sinuses [5,6].…”

Section: Introductionmentioning

confidence: 99%

Malignant transformation of sinonasal inverted papilloma and related genetic alterations: a systematic review

Gioacchini

Bajraktari

et al. 2017

Eur Arch Otorhinolaryngol

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Schneiderian papillomas are uncommon tumors which may develop within the nasal cavity and comprise three well-defined histological types: sinonasal inverted papilloma (SNIP), exophytic papilloma, and oncocytic papilloma. It is well known the rate of Schneiderian papilloma may also present a malignant degeneration and SNIP represents the most important subgroup in consideration of its frequency and malignant propensity. Although HPV infection is always considered the first event favoring the development of SNIP, however, it is not established as an eventual connection between viral actions and malignant transformation. In fact, different molecular mechanisms are suspected to play a crucial role in this process and, currently, many authors agree that only by improving our knowledge about these mechanisms it will be possible to achieve new and effective targeted therapies. So the aim of this study was firstly to systematically review the literature focusing on different biomarkers that could be implicated in the stages of SNIP malignant degeneration. Secondly, a systematic review with meta-analysis was performed to better define the incidence of sinonasal malignancies originating from Schneiderian papilloma (SNIP, exophytic papilloma, and oncocytic papilloma). Twenty-nine studies comprising a total of 3177 patients were statistically analyzed. Results showed a 9% (95% CI = 7-11) overall rate of malignant transformation from Schneiderian papilloma. In conclusion, this analysis confirmed that the potential malignancy of Schneiderian papilloma should not be underestimated. On the other hand, our review showed the paucity of studies investigating the molecular alterations which may be related with the malignant transformation of SNIP.

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“…A case control study demonstrated a positive correlation between inhalation of smoke, dust, and aerosol and IP burden . Similarly, other groups have determined that both outdoor and industrial occupations are risk factors for the development of IPs . In the mouse model, Herrold et al exposed animals to the toxin diethylnitrosamine and found that it led to the formation IPs in vivo .…”

Section: Discussionmentioning

confidence: 97%

Inverted schneiderian papilloma of the supraglottis: Case report

et al. 2017

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Inverted schneiderian papillomas are rare benign tumors, most often arising from the sinonasal mucosa. We describe a case of a 59-year-old female with an inverted papilloma of the supraglottis. This is the first reported case of a supraglottic-presenting inverted papilloma. Although rare, this case demonstrates that these tumors should be considered during workup of supraglottic laryngeal masses. Laryngoscope, 127:2830-2832, 2017.

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Occupational risk factors for sinonasal inverted papilloma: a case–control study

Cited by 36 publications

References 17 publications

3-D nasal cultures: Systems toxicological assessment of a candidate modified-risk tobacco product

3-D nasal cultures: Systems toxicological assessment of a candidate modified-risk tobacco product

Malignant transformation of sinonasal inverted papilloma and related genetic alterations: a systematic review

Inverted schneiderian papilloma of the supraglottis: Case report

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