Occupational risk factors and prostate cancer in U.S. Blacks and Whites

Krstev, Srmena; Baris, Dalsu; Stewart, Patricia A.; Dosemeci, Mustafa; Swanson, G. Marie; Greenberg, Raymond S.; Schoenberg, Janet B.; Schwartz, Ann G.; Liff, Jonathan M.; Hayes, Richard B.

doi:10.1002/(sici)1097-0274(199811)34:5<421::aid-ajim2>3.0.co;2-t

Cited by 57 publications

(52 citation statements)

References 42 publications

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“…A large casecontrol study found that most of the jobs associated with prostate cancer had the potential for occupational PAH exposure [12]. In three separate studies that examined specific occupational exposures, two found modest associations between selected PAH sources and prostate cancer [14,15], while the third found no link between PAH-related exposures and prostate cancer [42].…”

Section: Discussionmentioning

confidence: 99%

“…PAH are thought to exert their carcinogenic properties through their ability to form PAH-DNA adducts [9][10][11]. Both casecontrol [12] and cohort [13] studies have found that most jobs associated with occupational PAH exposure have the potential for prostate cancer. Associations between prostate cancer and specific occupational PAH exposure sources have also been reported [14,15].…”

Section: Introductionmentioning

confidence: 99%

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Prostate cancer risk from occupational exposure to polycyclic aromatic hydrocarbons interacting with the GSTP1 Ile105Val polymorphism

Rybicki

Neslund‐Dudas

Nock

et al. 2006

Cancer Detection and Prevention

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Condensed Abstract-Men who carry the GSTP1 Val 105 variant who are exposed at high levels to occupational PAH are at increased risk for prostate cancer. This increased risk is more pronounced in men under age 60 or with a family history of prostate cancer.Background-Variation in the glutathione S-transferase (GSTP1) gene and occupational polycyclic aromatic hydrocarbons (PAH) exposure are putative prostate cancer risk factors. An Ile/ Val polymorphism in codon 105 of GSTP1 affects its enzymatic activity toward PAH detoxification, a possible mechanism in prostate carcinogenesis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prostate cancer risk from occupational exposure to polycyclic aromatic hydrocarbons interacting with the GSTP1 Ile105Val polymorphism

Rybicki

Neslund‐Dudas

Nock

et al. 2006

Cancer Detection and Prevention

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“…We also saw a non-significant increase in prostate cancer risk for Caucasian men employed in service (OR=2.64, 95% CI 0.82-8.48). Krstev et al [17] reported elevated prostate cancer risks among African-American men, but not Caucasian men, for plant and system operators (OR=4.06) and other laborers (OR=1.37) (which are within our production occupations category), and African-American and Caucasian men employed in service (OR=1.41). They attributed these findings to potential exposure to polycyclic aromatic hydrocarbons.…”

Section: Discussionmentioning

confidence: 84%

Lifestyle and Prostate Cancer Among Older African-American and Caucasian Men in South Carolina

Sanderson¹,

Coker

Logan³

et al. 2004

Cancer Causes Control

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Objective-We investigated the association between lifestyle and prostate cancer risk among Caucasian and African-American men, separately.Methods-This population-based case-control study of prostate cancer among men aged 65-79 years was conducted between 2000 and 2002 in South Carolina. Telephone interviews were completed with 416 incident prostate cancer cases ascertained through the South Carolina Central Cancer Registry, and 429 controls identified through the Health Care Financing Administration Medicare beneficiary file (with respective response rates of 71% and 64%).Results-Caucasian men working in production, transportation, and material moving had increased prostate cancer risk (odds ratio [OR]=2.04, 95% confidence interval [CI] 1.17-3.54), while African-American men in the military had reduced prostate cancer risk (OR=0.19, 95% CI 0.05-0.76). Having five or more prostate specific antigen (PSA) tests within the past five years was associated with prostate cancer among Caucasian men; however, African-American men with prostate cancer tended to have fewer PSA tests. Increasing lycopene consumption was associated with a reduced risk of prostate cancer among Caucasian men (p=0.03), but not among AfricanAmerican men.Conclusions-In this population-based case-control study conducted in South Carolina we did not find marked differences in lifestyle factors associated with prostate cancer by race.

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“…Krstev, Burgess, Crutchfield, Storment, Gerkin, and Winston (1998a,b) performed two case studies on prostate cancer: a smaller study based on 981 pathologically confirmed prostate cancer cases (Krstev et al, 1998a) and a larger study based on 60,878 American men who died of prostate cancer (Krstev et al, 1998b). The smaller case study by Krstev et al (1998a) which was a case study on 981 new pathologically confirmed prostate cancer cases included 479 blacks and 502 whites who were diagnosed between 1986 and 1989, and 1,315 population controls (594 blacks and 721 whites). All of the cases and controls resided in either: Atlanta, Detroit, or in 10 counties in New Jersey.…”

Section: Resultsmentioning

confidence: 99%

“…In this small case-control study, the authors calculated odds ratios (ORs) with 95% confidence intervals (95% CI). The results indicated that firefighters had an increased risk of developing prostate cancer (chi2 trend, p = 0.02) (Krstev et al, 1998a). Due to the dependence on recall, the interviews can only show patterns of chemical exposure without scientific validity.…”

Section: Resultsmentioning

confidence: 99%

The Risk of Prostate Cancer from Occupational Exposures in Male Firefighters

Wong¹,

Gomes²

2011

RISS-IJHS

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Le cancer de la prostate est le cancer le plus fréquemment diagnostiqué chez les hommes. Étant donné qu'il se développe lentement, on peut prévenir la mortalité si on détecte et traite la tumeur alors qu'elle n'en est encore qu'à ses premiers stades de développement. On a démontré que des facteurs environnementaux pouvaient augmenter le risque de cancer de la prostate. Quelques recherches ont été effectuées sur les niveaux de cancer de la prostate chez les pompiers, mais peu d'articles ont été publiés à ce sujet. Cette étude vise à trouver une corrélation entre le métier de pompier et le niveau de cancer de la prostate. L'article indique des agents cancérigènes potentiels liés au métier de pompier. Cette étude analyse cinq articles ayant utilisé différentes méthodes d'obtention des cas et des cohortes étudiés, ainsi que diverses méthodes de comparaison. Néanmoins, les articles étudiés ont conclu à une corrélation positive entre le niveau d'exposition des pompiers dans le cadre de leur métier et le niveau de cancer de la prostate. Les produits chimiques suspectés d'être des agents cancérigènes par ces études sont les hydrocarbures aromatiques polycycliques (HAP) et la fumée d'incendie. Cependant, les études ultérieures devront être plus rigoureuses dans le calcul des niveaux de cancer de la prostate, en tenant compte de facteurs liés au style de vie, et d'autres variables confondantes comme le tabac et la durée estimée de l'exposition. Mots-clés :Pompier, exposition professionnelle, néoplasme de la prostate Abstract:Prostate cancer is the most commonly diagnosed cancer among men. Since prostate cancer is a slow developing cancer, mortality can be prevented if the tumour is detected and treated in its early stages. There is proof that environmental exposures can increase the risk of prostate cancer. Many papers have performed data analyses on prostate cancer levels in firefighters. There has been some research on firefighter prostate cancer levels but few reviews on the topic. This paper focuses on finding whether there is a correlation between firefighting occupation and levels of prostate cancer. As well, this paper notes potential carcinogens within the firefighting occupation. Five papers were included in this review; these papers used different methods to obtain the cases and cohorts for the study. The papers also used different controls for comparison. Nevertheless, the papers found in the search supported a positive correlation between exposures in firefighting occupations and the level of prostate cancer. The two chemicals that were suspected carcinogens in these studies were Polyaromatic hydrocarbons (PAH) and fire smoke. However, future research can be more rigorous in calculations of prostate cancer levels by including lifestyle factors, other confounders such as smoking, and estimated length of exposure.

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Occupational risk factors and prostate cancer in U.S. Blacks and Whites

Cited by 57 publications

References 42 publications

Prostate cancer risk from occupational exposure to polycyclic aromatic hydrocarbons interacting with the GSTP1 Ile105Val polymorphism

Prostate cancer risk from occupational exposure to polycyclic aromatic hydrocarbons interacting with the GSTP1 Ile105Val polymorphism

Lifestyle and Prostate Cancer Among Older African-American and Caucasian Men in South Carolina

The Risk of Prostate Cancer from Occupational Exposures in Male Firefighters

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