Occupational Respiratory Allergic Diseases in Healthcare Workers

Mazurek, Jacek M.; Weissman, David N.

doi:10.1007/s11882-016-0657-y

Cited by 22 publications

(14 citation statements)

References 83 publications

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“…Work-related asthma (WRA) subsumes occupational asthma and work-exacerbated asthma, and is a common but preventable respiratory disease occurring in the workplace (Friedman-Jimenez et al, 2015;Tarlo et al, 2008). In 2016, WRA affected as many as 2.7 million U.S. workers, especially healthcare workers who had among the highest prevalence of current and lifetime asthma (10.7-12.4%) (Dodd and Mazurek, 2016;Mazurek and Weissman, 2016;Wiszniewska and Walusiak-Skorupa, 2014). Asthma is a heterogeneous disease characterized by chronic airway inflammation, with variable airflow limitation and symptoms such as wheeze, chest tightness, frequent cough, and shortness of breath (SOB) (Global Initiative for Asthma, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…Several recent reviews of epidemiologic studies have identified cleaning and disinfecting activities (CDAs) as important risk factors for asthma-related outcomes among healthcare workers (Folletti et al, 2017;Mazurek and Weissman, 2016;Wiszniewska and Walusiak-Skorupa, 2014;Zock et al, 2010). However, the complexity of CDAs and the exposures they generate in healthcare settings has rarely been examined.…”

Section: Introductionmentioning

confidence: 99%

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Clustering asthma symptoms and cleaning and disinfecting activities and evaluating their associations among healthcare workers

Friesen

Humann

et al. 2019

International Journal of Hygiene and Environmental Health

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Asthma is a heterogeneous disease with varying severity and subtypes. Recent reviews of epidemiologic studies have identified cleaning and disinfecting activities (CDAs) as important risk factors for asthma-related outcomes among healthcare workers. However, the complexity of CDAs in healthcare settings has rarely been examined. This study utilized a complex survey dataset and data reduction approaches to identify and group healthcare workers with similar patterns of asthma symptoms, and then explored their associations with groups of participants with similar patterns of CDAs. Self-reported information on asthma symptoms/care, CDAs, demographics, smoking status, allergic status, and other characteristics were collected from 2030 healthcare workers within nine selected occupations in New York City. Hierarchical clustering was conducted to systematically group participants based on similarity of patterns of the 27 asthma symptom/care variables, and 14 product applications during CDAs, separately. Word clouds were used to visualize the complex information on the resulting clusters. The associations of asthma health clusters (HCs) with exposure clusters (ECs) were evaluated using multinomial logistic regression. Five HCs were identified (HC-1 to HC-5), labelled based on predominant features as: "no symptoms", "winter cough/phlegm", "mild asthma symptoms", "undiagnosed/untreated asthma", and "asthma attacks/exacerbations". For CDAs, five ECs were identified (EC-1 to EC-5), labelled as: "no products", "housekeeping/chlorine", "patient care", "general cleaning/laboratory", and "disinfection products". Using HC-1 and EC-1 as the reference groups, EC-2 was associated with HC-4 (odds ratio (OR)=3.11, 95% confidence interval (95% CI)=1.46-6.63) and HC-5 (OR=2.71, 95% CI=1.25-5.86). EC-3 was associated with HC-5 (OR=2.34, 95% CI=1.16-4.72). EC-4 was associated with HC-5 (OR=2.35, 95% CI=1.07-5.13). EC-5 was associated with HC-3 (OR=1.81, 95% CI=1.09-2.99) and HC-4 (OR=3.42, 95% CI=1.24-9.39). Various combinations of product applications like using alcohols, bleach, high-level disinfectants, and enzymes to disinfect instruments and clean surfaces captured by the ECs were identified as risk factors for the different asthma symptoms clusters, indicating that prevention efforts may require targeting multiple products. The associations of HCs with EC can be used to better inform prevention strategies and

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clustering asthma symptoms and cleaning and disinfecting activities and evaluating their associations among healthcare workers

Friesen

Humann

et al. 2019

International Journal of Hygiene and Environmental Health

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“…Asma terkait pekerjaan meliputi asma kerja (occupational asthma) dan asma yang diperburuk oleh faktor pekerjaan (work-exacerbated asthma). 1 Diantara penderita asma dewasa yang ada saat ini, diperkirakan 9% diantaranya adalah tena-ga kesehatan yang mengalami asma terkait kerja.…”

Section: Pendahuluanunclassified

“…Sebanyak 42,3% dari penderita asma tersebut terkait pekerjaannya di sarana kesehatan secara umum dan 40,2% lainnya terkait dengan pekerjaanya di rumah sakit. 1…”

Section: Pendahuluanunclassified

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Occupational Asthma in Hospital Healthcare Worker

Budianto

Astuti

2020

J Respirol Indones

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Occupational asthma is defined as an adult onset of asthma triggered by specific exposures or combinations from the workplace. Occupational asthma is classified into a sensitizer-induced occupational asthma or allergic occupational asthma caused by exposure or sensitization by a causative agents induced by immunological reactions; and irritant-induced occupational asthma or non-allergic occupational asthma caused by agents that are irritative to the airway. Occupational asthma can occur in health workers at hospitals. In the hospital there are various exposure of agents, medicines, and health equipments which can induce the asthma symptoms for health workers. The diagnosis of occupational asthma established by history taking, physical examination, supporting examination (spirometry, bronchial hyper-responsiveness test, exhaled nitric oxide, and immunological tests), and biomarker test. Management of occupational asthma includes principle management by avoiding exposure, pharmacological therapy, and immunotherapy. Precautions taken by primary, secondary (medical surveilance) and tertiary prevention (prevention of disability through worker’s compensation system).

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Work‐related allergy and asthma associated with cleaning agents in health workers in Southern African tertiary hospitals

Mwanga

Baatjies

Singh

et al. 2022

American J Industrial Med

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Background: Health workers (HWs) are exposed to diverse cleaning agents in large hospitals. This study determined the prevalence of work-related symptoms, allergic sensitization, and lung function abnormalities in HWs of two tertiary hospitals in Southern Africa. Methods: A cross-sectional study of 699 HWs (South Africa: SAH, n = 346; Tanzania: TAH, n = 353) was conducted. Health outcomes were assessed using a standardized ECRHS questionnaire, immunological tests (specific IgE antibody to common aeroallergens and to occupational allergens: natural rubber latex [NRL] Hev b5 and Hev b6.02, chlorhexidine, and ortho-phthalaldehyde [OPA]), spirometry [pre-and postbronchodilator], methacholine challenge, and fractional exhaled nitric oxide (FeNO).Results: A large proportion of participants (78%) were women. Median age was 42 years, with 76% nurses, 12% cleaners, and 5% administrative workers. Current smoking was more common in SAHWs (12%) than TAHWs (1%). The overall prevalence of doctor-diagnosed asthma was 7%. Atopy was present in 43% of HWs, while 4% were sensitized to OPA, 2% to NRL, and 1% to chlorhexidine. Prevalence of work-related ocular-nasal symptoms (16%) was higher than skin (12%) and chest (7%) symptoms. TAHWs had significantly lower mean lung volumes, higher degrees of significant airflow obstruction and impaired lung function. The prevalence of bronchial hyperresponsiveness in SAHWs (14%) was high. Overall, 23% of HWs had abnormal FeNO; 6% having high (>50 ppb) levels. FeNO was positively associated with sensitization to occupational allergens, primarily OPA and NRL.Conclusions: HWs from both hospitals had similar prevalence of work-related respiratory symptoms. Sensitization to OPA and NRL appears to be contributing to allergic airway inflammation in these HWs.

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Occupational Respiratory Allergic Diseases in Healthcare Workers

Cited by 22 publications

References 83 publications

Clustering asthma symptoms and cleaning and disinfecting activities and evaluating their associations among healthcare workers

Clustering asthma symptoms and cleaning and disinfecting activities and evaluating their associations among healthcare workers

Occupational Asthma in Hospital Healthcare Worker

Work‐related allergy and asthma associated with cleaning agents in health workers in Southern African tertiary hospitals

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