Occupational Pesticide Use and Risk of Renal Cell Carcinoma in the Agricultural Health Study

Abstract

BACKGROUND: Agricultural work and occupational pesticide use have been associated with increased risk of renal cell carcinoma (RCC), the most common form of kidney cancer. However, few prospective studies have investigated links to specific pesticides. OBJECTIVE: We evaluated the lifetime use of individual pesticides and the incidence of RCC. METHODS: We evaluated the associations between intensity-weighted lifetime days (IWDs) of 38 pesticides and incident RCC in the Agricultural Health Study, a prospective cohort of licensed pesticide applicators in Iowa and North Carolina. Among 55,873 applicators, 308 cases were diagnosed between enrollment (1993-1997) and the end of follow-up (2014-2015). We estimated incidence rate ratios (RRs) and 95% confidence intervals (CIs) using Poisson regression, controlling for potential confounding factors, with lagged and unlagged pesticide exposures. RESULTS: There was a statistically significant increased risk of RCC among the highest users of 2,4,5-T compared with never users [unlagged RR IWD Tertile 3 = 2:92 (95% CI: 1.65, 5.17; p trend = 0:001)], with similar risk estimates for lagged exposure [20-y lag RR IWD Tertile 3 = 3:37 (95% CI: 1.83, 6.22; p trend = 0:001)]. In 20-y lagged analyses, we also found exposure-response associations with chlorpyrifos [

Sex and Gender Differences in Kidney Cancer: Clinical and Experimental Evidence

“…While exposure to cancerogenous substances is a known risk factor to RCC development in both sexes, males face an increased risk of occupational hazards. For example, an epidemiologic study shows a statistically significant increased risk of RCC among the highest users of 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), an herbicide [29]. The authors enrolled 57,310 individuals seeking licenses to apply for restricted-use pesticides in Iowa and North Carolina between 1993 and 1997, of whom only about 2.7% were female [29].…”

“…For example, an epidemiologic study shows a statistically significant increased risk of RCC among the highest users of 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), an herbicide [29]. The authors enrolled 57,310 individuals seeking licenses to apply for restricted-use pesticides in Iowa and North Carolina between 1993 and 1997, of whom only about 2.7% were female [29]. Similarly, in a study presenting a dose-dependent association between RCC and exposure to metalworking fluids among autoworkers, the cohort consisted of 33,421 individuals, of whom 86.5% were males [30].…”

Flexibilização da regulação de agrotóxicos enquanto oportunidade para a (necro)política brasileira: avanços do agronegócio e retrocessos para a saúde e o ambiente

“…Além de elevada toxicidade aguda, o paraquate apresenta potencial genotóxico (Garaj-Vrhovac & Zeljezic, 2002), está associado à ocorrência de cânceres (Andreotti et al, 2020;Park et al, 2009) e desordens neurodegenerativas como parkinsonismo (Tangamornsuksan et al, 2019). A decisão de manter o seu uso permite que a população continue se expondo a um produto considerado pela própria Anvisa como causador de graves danos à saúde (Anvisa, 2017).…”

The Effects of Triazine Herbicides on Critical Peroxide Metabolism Gene Expression in MCF-7 and MCF-10A Cells

“…cancerous immortalized cell line MCF-10A, were treated with the same concentrations of atrazine or simazine as used in our oxidative stress ssays (Table 1), however for gene expression the cells were harvested and RNA levels examined after twenty-four hours. We also included cyanazine for comparison, as it has known toxicity [33][34][35]. We selected several genes within the peroxide pathways for examination.…”