Occupational pesticide exposure, cancer and chronic neurological disorders: A systematic review of epidemiological studies in greenspace workers

Graaf, Lucie De; Boulanger, Mathilde; Bureau, Mathilde; Bouvier, Ghislaine; Meryet‐Figuiere, Matthieu; Tual, Séverine; Lebailly, Pierre; Baldi, Isabelle

doi:10.1016/j.envres.2021.111822

Cited by 28 publications

(13 citation statements)

References 76 publications

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“…Titles and abstracts were screened for all papers produced by the literature search. Studies excluded from the primary analyses during title and abstract screening were reviews, [24][25][26] editorials, 27 animal or in vitro studies, 28 mechanistic studies (even if they used endpoints potentially related to clinical cancer, as epigenetic markers, telomere length, endocrine response), [29][30][31][32] papers on study protocols, 33 biostatistics methods papers, 34,35 epidemiological profiles and cohort descriptions, 36,37 risk/ exposure assessments 38 and other studies where human cancer was not a primary outcome. 39 The following search terms were used in PubMed to identify relevant journal articles assessing the relationship between human exposure to pesticides and cancer, which were published in 2017 or later:…”

Section: Methodsmentioning

confidence: 99%

Exposures to pesticides and risk of cancer: Evaluation of recent epidemiological evidence in humans and paths forward

Cavalier

Trasande

Porta

2022

Intl Journal of Cancer

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Knowledge of the role in cancer etiology of environmental exposures as pesticides is a prerequisite for primary prevention. We review 63 epidemiological studies on exposure to pesticides and cancer risk in humans published from 2017 to 2021, with emphasis on new findings, methodological approaches, and gaps in the existing literature. While much of the recent evidence suggests causal relationships between pesticide exposure and cancer, the strongest evidence exists for acute myeloid leukemia (AML) and colorectal cancer (CRC), diseases in which the observed associations were consistent across several studies, including high‐quality prospective studies and those using biomarkers for exposure assessment, with some observing dose‐response relationships. Though high‐quality studies have been published since the IARC monograph on organophosphate insecticides in 2017, there are still gaps in the literature on carcinogenic evidence in humans for a large number of pesticides. To further knowledge, we suggest leveraging new techniques and methods to increase sensitivity and precision of exposure assessment, incorporate multi‐omics data, and investigate more thoroughly exposure to chemical mixtures. There is also a strong need for better and larger population‐based cohort studies that include younger and nonoccupationally exposed individuals, particularly during developmental periods of susceptibility. Though the existing evidence has limitations, as always in science, there is sufficient evidence to implement policies and regulatory action that limit pesticide exposure in humans and, hence, further prevent a significant burden of cancers.

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Section: Methodsmentioning

confidence: 99%

Exposures to pesticides and risk of cancer: Evaluation of recent epidemiological evidence in humans and paths forward

Cavalier

Trasande

Porta

2022

Intl Journal of Cancer

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“…However, pesticides have adverse effects on environments, ecosystems, and humans. Exposure to pesticides can cause acute and chronic health effects, depending on doses of exposure, types of pesticides, and route of entry, including cancers, diabetes, chronic kidney disease, asthma, and neurological diseases [ 2 , 3 , 4 , 5 , 6 ]. Ingestion is the main route of exposure in the general population and consumers, who are primarily exposed to pesticides through eating food and drinking water contaminated with pesticide residues [ 3 , 4 , 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Determinants of Consumers’ Behavior in Reducing Pesticide Residues in Vegetables and Fruits, Northern Thailand

Sapbamrer

Chittrakul

2022

IJERPH

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Pesticide residues in vegetables in northern Thailand exceed the maximum residue limits established by the European Union. Therefore, improved knowledge and behavior in reducing pesticide residues in vegetables and fruits (VF) would reduce the risk of exposure to pesticides. This study aims to investigate the contributing factors of consumers’ behavior in reducing pesticide residues in VF. The differences in knowledge, attitude, and behavior in reducing pesticide residues in VF between consumers living in rural and urban communities of Chiang Mai, Thailand were also investigated. The cross-sectional study was carried out during August and October 2021 with 456 participants. Data was collected from participants using a Google form questionnaire. The results indicated that pesticide-free was the top-ranked consideration for VF purchasing. Linear regression analysis found that factors associated with consumers’ behavior in reducing pesticide residues in VF were total knowledge scores (Beta (β) ± standard error (SE.) = 1.15 ± 0.18, 95%CI = 0.79, 1.51), total attitude scores (β ± SE. = 1.30 ± 0.49, 95%CI = 3.87, 10.40), having co-morbidity (β ± SE. = 3.2 ± 1.37, 95%CI = 0.52, 5.90), type of VF purchasing (β ± SE. = 1.98 ± 0.57, 95%CI = 0.85, 3.11), frequency of VF purchasing (β ± SE. = 3.81 ± 1.18, 95%CI = 1.49, 6.13), price of VF products (β ± SE. = −2.23 ± 1.13, 95%CI = −4.45, −0.02), and getting information from the broadcasting tower in the village (β ± SE. = 7.13 ± 1.66, 95%CI = 0.32, 2.27).

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“…Direct contact with pesticides is the leading cause of cancer around the world. This is a global issue that is presently fascinating researchers from all around the world [ 185 , 186 ].…”

Section: Resultsmentioning

confidence: 99%

Pesticides impacts on human health and the environment with their mechanisms of action and possible countermeasures

Ahmad,

Alsayegh

et al. 2024

Heliyon

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Occupational pesticide exposure, cancer and chronic neurological disorders: A systematic review of epidemiological studies in greenspace workers

Cited by 28 publications

References 76 publications

Exposures to pesticides and risk of cancer: Evaluation of recent epidemiological evidence in humans and paths forward

Exposures to pesticides and risk of cancer: Evaluation of recent epidemiological evidence in humans and paths forward

Determinants of Consumers’ Behavior in Reducing Pesticide Residues in Vegetables and Fruits, Northern Thailand

Pesticides impacts on human health and the environment with their mechanisms of action and possible countermeasures

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