Occupational lead exposure is an independent modulator of hypertension and poor pulmonary function: A cross-sectional comparative study in lead-acid battery recycling workers

Yadav, Shiv Kumar; Patil, Gajanan P; Virmagami, Ankit; Bijalwan, Vandana; Devi, Kamalini; Chauhan, Aakriti; Gupta, Sanjeev Kumar; Fathima, Shabarin; Naorem, Chaoba D; Yadav, Suresh; Singh, Gyanendra; Mishra, SukhDev; Bishnoi, Mahendra; Sarkar, Kamalesh; Singh, D. P.

doi:10.1177/07482337221076248

Cited by 9 publications

(7 citation statements)

References 50 publications

(54 reference statements)

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“…At the same time, we found that born in other countries, citizen in other ways, longer stays in the United States, under high school graduate, living with a companion, and total number of people in the family ≤3 might be risk factors associated with blood lead level. Although there have been few studies to explain why people with these characteristics had higher blood lead levels, we know that lead exposure is occupational and is associated with poor living conditions ( 28 , 29 ), so we speculate that the participants in this study with higher blood lead levels might have been at a higher risk of lead exposure due to their work and living conditions. For example, people with lower levels of education might be less aware of protection at work ( 30 ).…”

Section: Discussionmentioning

confidence: 85%

Blood Lead Exposure and Association With Hepatitis B Core Antibody in the United States: NHANES 2011–2018

Han

Huang

et al. 2022

Front. Public Health

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The objective of this project was to explore the distribution and related factors of blood lead and the association between blood lead and hepatitis B core antibody (HBcAb). All the data were from the U.S. National Health and Nutrition Examination Survey (NHANES). In total, 15,097 (aged 20–80 years) participants were included. Participants without a history of blood transfusion were more likely to be exposed to lower levels of blood lead [−2.30 (−3.13, −1.47) for HBcAb (–) and −2.23 (−4.54, 0.08) for HBcAb (+)]. The odds ratio (OR) of HBcAb (+) increased with blood lead and the result was 1.09 (1.06, 1.12). This study showed that older adults, men, people with a lower education level, a lower ratio of family income to poverty (PIR), a lower body mass index (BMI), or a history of blood transfusion, people who lived with a companion or with a total number of people in the family >3, people living in the United States for a longer time, U.S. citizens by birth or naturalization, and people not born in the United States were associated with higher blood lead exposure, and blood lead had a positive association with HBcAb (+).

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Section: Discussionmentioning

confidence: 85%

Blood Lead Exposure and Association With Hepatitis B Core Antibody in the United States: NHANES 2011–2018

Han

Huang

et al. 2022

Front. Public Health

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“…The use of body mass index as a measure of health status of humans is quite popular as it gives an indication of the vulnerability of humans to certain chronic diseases such as diabetes, hypertension and cardiovascular diseases (Ge et al, 2021; Yadav et al, 2022; Yoon et al, 2021). The normal range of body mass index for a healthy man was 18–24.9 kg/m 2 (Zhao et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

“…Elevated levels of bilirubin in the blood have been associated with adverse medical conditions such as hepatitis, cirrhosis, haemolytic jaundice and obstruction of the biliary tract (Ding et al, 2021; Hamoud et al, 2018). The significant lower levels of platelets in the exposed subjects than the controls could be an indication that the subjects were exposed to increased risks of blood clotting since platelets play an important role in blood clotting (Chokpitakkul, 2022; Yadav et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Health implications of pesticides application among cocoa farmers in Idanre local government area, Southwest Nigeria

2023

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Pesticides are routinely applied by cocoa farmers to enhance cocoa production, which is threatened by pest infestations and diseases. However, the undesired health implications of pesticide applications on the farmers are yet to be fully elucidated especially among cocoa farmers in Idanre despite being the hub of cocoa production in Southwestern Nigeria. This study assessed the extent of pesticide use by cocoa farmers in the study area and determined the effects of exposure on their health using haematological and biochemical parameters as indices. A cross-sectional survey comprising 150 cocoa farmers and 50 controls (artisans) was carried out using structured questionnaire. Blood samples were obtained from participants for the determination of copper and sulphate levels, haematological (haematocrit, red blood cell counts, white blood cell counts and platelet counts) and biochemical (creatinine, cholesterol, direct bilirubin and total bilirubin) parameters. The blood levels of copper and sulphate were significantly higher in the cocoa farmers than in the controls. However, there was no significant difference between the subjects and controls for most of the haematological and biochemical parameters except for the platelet counts and total bilirubin levels. The data from the study did not suggest any serious health effects due to pesticide exposure on the cocoa farmers despite the high blood levels of copper and sulphate, probably due to exposure to copper-based fungicides. However, the high serum bilirubin level among the subjects was an indication of possible liver damage. As such, cocoa farmers should be guided against indiscriminate use of pesticides on their farms.

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“…Importantly, we also found that AF/AFL mortality and DALYs attributable to lead exposure are on the rise in low-and low-middle-SDI countries for both male and female populations. Previous studies determined that lead exposure was strongly associated with hypertension [23], acute ischemic stroke [24], and heart failure [25], and that reducing lead exposure can result in substantial advantages for the adult population [26]. Lead exposure should be a prioritised topic, especially in nations and regions with a low or low-middle SDI.…”

Section: Additional Materialsmentioning

confidence: 99%

Global, regional, and national burdens of atrial fibrillation/flutter from 1990 to 2019: An age-period-cohort analysis using the Global Burden of Disease 2019 study

Li,

Liu,

Jiang

et al. 2023

J Glob Health

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Background Atrial fibrillation/flutter (AF/AFL) significantly impacts countries with varying income levels. We aimed to present worldwide estimates of its burden from 1990 to 2019 using data from the Global Burden of Disease (GBD) study. MethodsWe derived cause-specific AF/AFL mortality and disability-adjusted life-year (DALY) estimates from the GBD 2019 study data. We used an age-period-cohort (APC) model to predict annual changes in mortality (net drifts), annual percentage changes from 50-55 to 90-95 years (local drifts), and period and cohort relative risks (period and cohort effects) between 1990 and 2019 by sex and sociodemographic index (SDI) quintiles. This allowed us to determine the impacts of age, period, and cohort on mortality and DALY trends and the inequities and treatment gaps in AF/ AFL management. ResultsBased on GBD data, our estimates showed that 59.7 million cases of AF/AFL occurred worldwide in 2019, while the number of AF/AFL deaths rose from 117 000 to 315 000 (61.5% women). All-age mortality and DALYs increased considerably from 1990 to 2019, and there was an increase in age risk and a shift in death and DALYs toward the older (>80) population. Although the global net drift mortality of AF/AFL decreased overall (-0.16%; 95% confidence interval (CI) = -0.20, 0.12 per year), we observed an opposite trend in the low-middle SDI (0.53%; 95% CI = 0.44, 0.63) and low SDI regions (0.32%; 95% CI = 0.18, 0.45). Compared with net drift among men (-0.08%; 95% CI = -0.14, -0.02), women had a greater downward trend or smaller upward trend of AF/AFL (-0.21%; 95% CI = -0.26, -0.16) in mortality in middle-and low-middle-SDI countries (P < 0.001). Uzbekistan had the largest net drift of mortality (4.21%; 95% CI = 3.51, 4.9) and DALYs (2.16%; 95% CI = 2.05, 2.27) among all countries. High body mass index, high blood pressure, smoking, and alcohol consumption were more prevalent in developed countries; nevertheless, lead exposure was more prominent in developing countries and regions. ConclusionsThe burden of AF/AFL in 2019 and its temporal evolution from 1990 to 2019 differed significantly across SDI quintiles, sexes, geographic locations, and countries, necessitating the prioritisation of health policies based on risk-differentiated, cost-effective AF/AFL management.

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Occupational lead exposure is an independent modulator of hypertension and poor pulmonary function: A cross-sectional comparative study in lead-acid battery recycling workers

Cited by 9 publications

References 50 publications

Blood Lead Exposure and Association With Hepatitis B Core Antibody in the United States: NHANES 2011–2018

Blood Lead Exposure and Association With Hepatitis B Core Antibody in the United States: NHANES 2011–2018

Health implications of pesticides application among cocoa farmers in Idanre local government area, Southwest Nigeria

Global, regional, and national burdens of atrial fibrillation/flutter from 1990 to 2019: An age-period-cohort analysis using the Global Burden of Disease 2019 study

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