Occupational lead exposure and amino acid profiles and liver function tests in industrial workers

Al-Neamy, F.R.M.; Almehdi, Ahmed M.; Alwash, R; Pasha, M. Asghar; Ahmad, Irfan; Bener, Abdülbari

doi:10.1080/09603120020047564

Cited by 40 publications

(24 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, the basic protein content elevated in hepatic tissue and decreased in the kidney and skeletal muscle. Change in hepatic basic protein level in the present study is in conformity with the earlier study on industrial workers (Al-Neamy et al 2001). Since the trypsin is responsible for site specific cleavage of the peptide bonds in basic proteins, reduced activity of trypsin may therefore induces over-accumulation of those proteins.…”

Section: Discussionsupporting

confidence: 92%

Lead (Pb), a threat to protein metabolic efficacy of liver, kidney and muscle in mice

Das

Pal

2017

Comp Clin Pathol

View full text Add to dashboard Cite

Lead, being the most dangerous natural heavy metal imposes metabolic dysfunction in organ system. However, the effect of lead on protein metabolic efficacy in the liver, kidney and skeletal muscle in mice has not been well studied. The aim of the present study is to establish the metabolic orientation between the liver, kidney and muscle upon subacute lead exposure to assess how protein and amino acid metabolisms are affected. Lead acetate was administered by gavage at a dose of 5 mg/kg b.w./once daily for 30 days. After the treatment, the liver, kidney and muscle were evaluated for biochemical parameters such as proteolytic enzyme activities (trypsin, cathepsin and pronase), tissue protein content (acidic, basic, neutral and total protein), protein carbonyl content, free amino nitrogen as well as tissue and serum transaminase activities. Degradation of total protein was noted in the liver and kidney possibly due to enhanced carbonylation of proteins whereas it was elevated in skeletal muscle. The proteolytic enzyme activity was inhibited in the liver and elevated in the kidney by lead treatment. Muscular cathepsin and trypsin activities decreased but the pronase activity enhanced following lead exposure. Moreover, a marked reduction of transaminase enzyme activities in all the tissues might be due to enzyme leakage from tissue to blood. Significant alteration in amino acid nitrogen in the affected tissue indicates adaptive mechanisms at play in the organ system. Lead is found to be responsible for alteration of tissue protein and amino acids in a toxic fashion and promotes a cooperative mechanism to minimize the metabolic distress imposed by lead.

show abstract

Section: Discussionsupporting

confidence: 92%

Lead (Pb), a threat to protein metabolic efficacy of liver, kidney and muscle in mice

Das

Pal

2017

Comp Clin Pathol

View full text Add to dashboard Cite

show abstract

“…Elevated BLL is a known multi-target toxicant, with effects on the haematopoietic, nervous, immune and gastrointestinal systems. (4)(5)(6)(7)(8)(9)(10) Abdominal pain is frequently reported when BLL is > 40 μg/dL. In the present study, anorexia and abdominal pain were found to be signifi cantly associated with elevated BLL.…”

Section: Discussionsupporting

confidence: 51%

“…BLLs ≥ 10 μg/dL, can result in adverse health effects including encephalopathy, cardiovascular disease, immune system disease and anaemia. (4)(5)(6)(7)(8)(9)(10) Lead primarily affects the central nervous system, particularly the development of the brain.…”

Section: Introductionmentioning

confidence: 99%

Surveillance of childhood blood lead levels in Chengdu, China in 2010–2011

Zhang¹,

Yang²,

Jiang³

et al. 2015

smedj

View full text Add to dashboard Cite

RESULTSThe mean BLL of the 2,271 children was 6.2 μg/dL and 2.03% of the children had BLLs ≥ 10 μg/dL. Mean BLL seemed to increase with age. Unhygienic habits (e.g. not washing hands frequently, biting of toys and pencils), history of pica, use of coal and residence in an industrial zone were found to be the main risk factors contributing to high BLL (p < 0.05). Children with high BLLs have a higher risk of manifesting anorexia and/or abdominal pain as compared to those with low BLLs (p < 0.05). CONCLUSIONThe mean BLL of children in Chengdu (i.e. 6.2 μg/dL) was found to be higher than that of children in developed countries. Childhood lead poisoning remains a public health problem.

show abstract

“…However, lead acetate in a dose of 5 mg/kg was not sufficient to induce bilirubin level elevation. Nevertheless, in studies of Mikhail et al (25) and Al-Neamy et al (26) bilirubin levels showed only an insignificant tendency to increase in workers exposed to lead, whereas Khan et al (14) reported that bilirubin concentration was not significantly decreased.…”

Section: Discussionmentioning

confidence: 92%

The Effect of Occupational Exposure to Lead on the Non-Enzymatic Antioxidant System

Dobrakowski¹,

Zalejska–Fiolka²,

Wielkoszyński³

et al. 2014

Med Pr

View full text Add to dashboard Cite

Background: The role of non-enzymatic antioxidants, such as uric acid, albumin, bilirubin, and α-tocopherol, in lead poisoning remains unclear. Therefore, the aim of the study was to explore the association between occupational exposure to lead and nonenzymatic antioxidant concentrations in serum and plasma. Material and Methods: The study population consisted of 278 healthy male employees of lead-zinc plants, with 129 workers classified as having low lead exposure (blood lead level -PbB = 20-39.9 μg/dl) and 149 workers classified as having high lead exposure (PbB = 40-59.8 μg/dl). The control group was composed of 73 healthy male administrative workers. No one from this group had blood lead level or zinc protoporphyrin (ZPP) level greater than normal levels, being 10 μg/dl and 2.5 μg/g of hemoglobin, respectively. In addition to the levels of PbB and ZPP, serum levels of uric acid (UA), albumin, thiol groups of albumin, and bilirubin were determined. The ferric reducing ability of plasma (FRAP) and the plasma level of α-tocopherol were also evaluated. Results: Lead exposure indices were significantly elevated in the examined subgroups as compared with the controls. Serum uric acid levels were significantly elevated in both subgroups, particularly in the group with high exposure. Serum bilirubin concentration was significantly elevated in the group with high exposure compared with the control group, while in the group with low exposure, it showed only a non-significant trend towards an increase. In contrast, ferric-reducing ability of plasma was not significantly greater in the examined subgroups as compared with the control group. Nevertheless, levels of albumin, thiol groups of albumin, and α-tocopherol levels were significantly decreased in the exposed subgroups compared with the control group. Conclusions: Occupational exposure to lead interferes with the blood non-enzymatic antioxidant system. Med Pr 2014;65(4): [443][444][445][446][447][448][449][450][451]

show abstract

Occupational lead exposure and amino acid profiles and liver function tests in industrial workers

Cited by 40 publications

References 20 publications

Lead (Pb), a threat to protein metabolic efficacy of liver, kidney and muscle in mice

Lead (Pb), a threat to protein metabolic efficacy of liver, kidney and muscle in mice

Surveillance of childhood blood lead levels in Chengdu, China in 2010–2011

The Effect of Occupational Exposure to Lead on the Non-Enzymatic Antioxidant System

Contact Info

Product

Resources

About