Occupational hypersensitivity pneumonitis after polyurethane adhesive exposure

Patel, Arbaaz; Hasany, Aasim; Tarlo, Susan M.

doi:10.1503/cmaj.220052

CMAJ

2022

DOI: 10.1503/cmaj.220052

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Occupational hypersensitivity pneumonitis after polyurethane adhesive exposure

Arbaaz Patel

Aasim Hasany

Susan M. Tarlo

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Cited by 4 publications

(1 citation statement)

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“…Neumonitis por hipersensibilidad: La neumonitis por hipersensibilidad, también conocida como alveolitis alérgica extrínseca, es una enfermedad pulmonar inflamatoria causada por la inhalación de sustancias orgánicas o inorgánicas que desencadenan una respuesta inmunológica exagerada en los pulmones 27 . Algunos de los signos radiológicos característicos de la neumonitis por hipersensibilidad incluyen opacidad en los pulmones que tienen una apariencia difusa, borrosa y granular, similar a un vidrio deslustrado, tienen un patrón de distribución centrípeto, es decir, más pronunciado en las zonas periféricas de los pulmones y disminuyendo hacia el centro.…”

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Salud Ocupacional: Mirada Normativa Para El Diagnóstico De Silicosis

Delgado-García

2023

Rev.Repub.

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Silicosis is an occupational lung fibrosis caused by the inhalation of dust containing free crystalline silica. Its prevalence can vary in different countries and regions. In the case of Chile, silicosis has been recognized as a significant occupational health problem. The clinical presentation of silicosis largely depends on the intensity and duration of exposure. Initially, there may be no signs or symptoms. The differential diagnosis is mainly performed with pulmonary tuberculosis, pulmonary aspergillosis, pulmonary metastasis, sarcoidosis, hypersensitivity pneumonitis, and other pneumoconiosis. After confirming the diagnosis, the process of determining the origin of the pathology begins, for which an Occupational History is required to describe occupational exposure to the risk agent (silica) in terms of time, magnitude, and/or intensity sufficient to develop an occupational-related disease. A Chest X-ray using the ILO (International Labour Organization) technique is necessary, classified as category 1 according to the ILO Classification, and should be interpreted by certified readers. The similarity in radiographic readings necessitates a greater emphasis on the differential diagnosis among these conditions. A high- resolution chest computed tomography without contrast and a lung biopsy should be considered in case of comorbidity, if these diagnostic tests are available. Finally, it is suggested that workers diagnosed with silicosis in the early stages should be identified and removed from silica exposure to prevent disability through medical surveillance.

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Salud Ocupacional: Mirada Normativa Para El Diagnóstico De Silicosis

Delgado-García

2023

Rev.Repub.

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Novel occupational causes of hypersensitivity pneumonitis

Walters

Huntley

2023

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of reviewHypersensitivity pneumonitis (HP) remains a challenging diagnosis, and a cause is not established in up to 50% of cases. This paper aims to update clinicians on traditional and novel occupational causes of HP, and clinical tools for identifying of causative exposures and antigens.Recent findingsMetalworking fluid has become the most frequently cited occupational cause of HP, though geographical variations in exposures exist. Occupational HP is usually associated with work-related symptoms. Systematically derived questionnaires and compendia for HP have been developed for use in cryptogenic disease, though have previously lacked validation; these may help identify inciting antigens or relevant occupational exposures.SummaryClinicians should enquire about job roles and work-relatedness of symptoms when considering a diagnosis of HP. Outbreaks of metalworking fluid associated HP from around the world are well described, so clinicians should remain vigilant. The usual classification for causative antigen includes animal and plant proteins, fungi, bacteria, low-molecular weight chemicals and metals; however novel occupational exposures and work processes are frequently reported.

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A 35-month-old boy who ingested laundry detergent pods and underwent veno-pulmonary extracorporeal membrane oxygenation support

Han,

Lee,

Jang

et al. 2023

Pediatr Emerg Med J

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Laundry detergent pod (LDP) exposure has been reported to be fatal in children younger than 2 years, leading to respiratory or central nervous system depression. While gastrointestinal irritation is the most common symptom, there are reported cases of severe acidosis with respiratory depression or pneumonia, resulting in mortality. To our best knowledge, there is no report on a case of LDP exposure presenting with acute respiratory distress syndrome requiring extracorporeal membrane oxygenation support. Here, we present a case of a child with severe acute respiratory distress syndrome following LDP exposure, who was successfully treated with veno-pulmonary extracorporeal membrane oxygenation and steroids.

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Occupational hypersensitivity pneumonitis after polyurethane adhesive exposure

Cited by 4 publications

References 9 publications

Salud Ocupacional: Mirada Normativa Para El Diagnóstico De Silicosis

Salud Ocupacional: Mirada Normativa Para El Diagnóstico De Silicosis

Novel occupational causes of hypersensitivity pneumonitis

A 35-month-old boy who ingested laundry detergent pods and underwent veno-pulmonary extracorporeal membrane oxygenation support

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