Occupational exposures and fluorescent oxidation products in 723 adults of the EGEA study

Dumas, Orianne; Matran, Régis; Zerimech, Farid; Decoster, Brigitte; Huyvaert, Hélène; Ahmed, Ismaïl; Moual, Nicole Le; Nadif, Rachel

doi:10.1183/09031936.00177614

Cited by 18 publications

(27 citation statements)

References 16 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, in the literature, as in our analyses, FlOPs were shown to be associated with irritant exposures, such as tobacco smoke ( [18] and online supplementary material) or occupational exposure to irritant chemicals (e.g. cleaning products) [29], which have also been associated with nonallergic asthma phenotypes [37][38][39][40].…”

Section: Discussionsupporting

confidence: 58%

See 1 more Smart Citation

Oxidative stress biomarkers and asthma characteristics in adults of the EGEA study

et al. 2017

Self Cite

View full text Add to dashboard Cite

Asthma is an oxidative stress related disease, but associations with asthma outcomes are poorly studied in adults. We aimed to study the associations between several biomarkers related to oxidative stress and various asthma outcomes.Cross-sectional analyses were conducted in 1388 adults (mean age 43 years, 44% with asthma) from the Epidemiological Study of the Genetics and Environment of Asthma (EGEA2). Three blood antioxidant enzyme activities (biomarkers of response to oxidative stress) and exhaled breath condensate 8-isoprostanes and plasma fluorescent oxidation products (FlOPs) levels (two biomarkers of damage) were measured. Associations between biomarkers and 1) ever asthma and 2) asthma attacks, asthma control and lung function in participants with asthma were evaluated using regression models adjusted for age, sex and smoking.Biomarkers of response were unrelated to asthma outcomes. Higher 8-isoprostane levels were significantly associated with ever asthma (odds ratio for one interquartile range increase 1.28 (95% CI 1.06-1.67). Among participants with asthma, 8-isoprostane levels were negatively associated with adult-onset asthma (0.63, 0.41-0.97) and FlOPs levels were positively associated with asthma attacks (1.33, 1.07-1.65), poor asthma control (1.30, 1.02-1.66) and poor lung function (1.34, 1.04-1.74).Our results suggest that 8-isoprostanes are involved in childhood-onset asthma and FlOPs are linked to asthma expression.

show abstract

Section: Discussionsupporting

confidence: 58%

“…Plasma FlOP levels were measured as previously described [18,29]. Briefly, plasma was extracted into a mixture of ethanol/ether (3/1 v/v) and measured using a spectrofluorimeter (360 nm excitation wavelength, 430 nm emission wavelength).…”

Section: Biomarkers Of Damagementioning

confidence: 99%

Oxidative stress biomarkers and asthma characteristics in adults of the EGEA study

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…Moreover, this single characteristic (allergic vs nonallergic) only accounts for a small part of asthma heterogeneity and is likely not sufficient to define relevant asthma phenotypes. Further studies using a better definition of allergic status, and with information on a broader range of clinical characteristics and relevant biomarkers, such as oxidative stress‐related markers, are needed to evaluate more accurately the association between occupational exposure and incidence of specific asthma phenotypes.…”

Section: Discussionmentioning

confidence: 99%

Occupational exposure to disinfectants and asthma incidence in U.S. nurses: A prospective cohort study

Dumas

Boggs

Quinot

et al. 2019

American J Industrial Med

Self Cite

View full text Add to dashboard Cite

Background: Exposure to disinfectants among healthcare workers has been associated with respiratory health effects, in particular, asthma. However, most studies are cross-sectional and the role of disinfectant exposures in asthma development requires longitudinal studies. We investigated the association between occupational exposure to disinfectants and incident asthma in a large cohort of U.S. female nurses. Methods: The Nurses' Health Study II is a prospective cohort of 116 429 female nurses enrolled in 1989. Analyses included 61 539 participants who were still in a nursing job and with no history of asthma in 2009 (baseline; mean age: 55 years). During 277 744 person-years of follow-up (2009-2015), 370 nurses reported incident physician-diagnosed asthma. Occupational exposure was evaluated by questionnaire and a Job-Task-Exposure Matrix (JTEM). We examined the association between disinfectant exposure and subsequent asthma development, adjusted for age, race, ethnicity, smoking status, and body mass index.Results: Weekly use of disinfectants to clean surfaces only (23% exposed) or to clean medical instruments (19% exposed) was not associated with incident asthma (adjusted hazard ratio [95% confidence interval] for surfaces, 1.12 [0.87-1.43]; for instruments, 1.13 [0.87-1.48]). No association was observed between high-level exposure to specific disinfectants/cleaning products evaluated by the JTEM (formaldehyde, glutaraldehyde, bleach, hydrogen peroxide, alcohol quats, or enzymatic cleaners) and asthma incidence. Conclusions:In a population of late career nurses, we observed no significant association between exposure to disinfectants and asthma incidence. A potential role of disinfectant exposures in asthma development warrants further study among healthcare workers at earlier career stage to limit the healthy worker effect. K E Y W O R D Sasthma, cleaning products, disinfection, healthcare workers, occupational asthma

show abstract

“…Some products (e.g. enzyme-based products) have sensitizing potential, but most agents are assumed to act as respiratory irritants [11], and may cause injury of the airway epithelium, oxidative stress and long-lasting neurogenic inflammation [23, 24, 29]. Regardless of the exact mechanisms, our results support the need to consider occupation and potential exposure to disinfectants in clinical practice to improve management of patients with asthma [6, 30].…”

Section: Discussionmentioning

confidence: 99%

Occupational exposure to disinfectants and asthma control in US nurses

et al. 2017

Self Cite

View full text Add to dashboard Cite

Disinfectant use has been associated with adverse respiratory effects among healthcare workers. However, the specific harmful agents have not been elucidated. We examined the association between occupational exposure to disinfectants and asthma control in the Nurses’ Health Study II, a large cohort of female nurses. Nurses with asthma were invited in 2014 to complete two questionnaires on their current occupation and asthma (response rate: 80%). Asthma control was defined by the Asthma Control Test (ACT). Exposure to major disinfectants was evaluated by a Job-Task-Exposure Matrix (JTEM). Analyses included 4,102 nurses with asthma (mean age: 58 years). Asthma control was poor (ACT=16–19) in 12% of nurses and very poor (≤15) in 6%. Use of disinfectants to clean medical instruments (19% exposed) was associated with poorly (odds ratio 1.37; 95%CI: [1.05–1.79]) and very poorly (1.88 [1.38–2.56]) controlled asthma (P-trend 0.004, after adjustment for potential confounders). Using JTEM estimates, exposure to formaldehyde, glutaraldehyde, hypochlorite bleach, hydrogen peroxide and enzymatic cleaners was associated with poor asthma control (all P-trend<0.05); exposure to quaternary ammonium compounds and alcohol was not. Use of several disinfectants was associated with poor asthma control. Our findings suggest targets for future efforts to prevent worsening of asthma control in healthcare workers.

show abstract

Occupational exposures and fluorescent oxidation products in 723 adults of the EGEA study

Cited by 18 publications

References 16 publications

Oxidative stress biomarkers and asthma characteristics in adults of the EGEA study

Oxidative stress biomarkers and asthma characteristics in adults of the EGEA study

Occupational exposure to disinfectants and asthma incidence in U.S. nurses: A prospective cohort study

Occupational exposure to disinfectants and asthma control in US nurses

Contact Info

Product

Resources

About