Occupational Exposures and Computed Tomographic Imaging Characteristics in the SPIROMICS Cohort

Paulin, Laura M.; Smith, Benjamin M.; Koch, Abby; Han, Mei Lan K.; Hoffman, Eric A.; Martínez, Carlos H.; Ejike, C.O.; Blanc, Paul D.; Rous, J; Barr, R. Graham; Peters, Stephen P.; Paine, Robert; Pirozzi, Cheryl; Cooper, Christopher B.; Comellas, Alejandro P.; Kanner, Richard E.; Drummond, M. Bradley; Putcha, Nirupama; Hansel, Nadia N.

doi:10.1513/annalsats.201802-150oc

Cited by 29 publications

(24 citation statements)

References 43 publications

(53 reference statements)

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“…Because both the high and low WTC exposure groups share the non-WTC occupational exposure of firefighting, the increased risk of CT abnormalities in the high exposure group is therefore attributable to WTC exposure. These data are consistent with prior case-control studies in WTC-exposed cohorts [10] and in occupational cohorts with high smoking prevalence [8,9].…”

Section: Discussionsupporting

confidence: 92%

“…Computed tomography (CT) can detect structural lung abnormalities in individuals with respiratory symptoms and normal spirometry [7]. Self-report of exposure to vapors, gas, dust, or fumes was associated with an increase in emphysema, bronchial wall thickening, and air trapping on quantitative CT imaging in cohorts of smokers without WTC exposure [8,9]. Bronchial wall thickening was associated with FEV 1 decline in WTC-exposed cohorts [3,10,11].…”

Section: Introductionmentioning

confidence: 99%

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Abnormalities on Chest Computed Tomography and Lung Function Following an Intense Dust Exposure: A 17-Year Longitudinal Study

Liu

Putman

Singh

et al. 2019

IJERPH

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Fire Department of the City of New York (FDNY) firefighters experienced intense dust exposure working at the World Trade Center (WTC) site on and after 11/9/2001 (9/11). We hypothesized that high-intensity WTC exposure caused abnormalities found on chest computed tomography (CT). Between 11/9/2001–10/9/2018, 4277 firefighters underwent a clinically-indicated chest CT. Spirometric measurements and symptoms were recorded during routine medical examinations. High-intensity exposure, defined as initial arrival at the WTC on the morning of 9/11, increased the risk of bronchial wall thickening, emphysema, and air trapping. Early post-9/11 symptoms of wheeze and shortness of breath were associated with bronchial wall thickening, emphysema, and air trapping. The risk of accelerated forced expiratory volume at one second (FEV1) decline (>64 mL/year decline) increased with bronchial wall thickening and emphysema, but decreased with air trapping. The risk of airflow obstruction also increased with bronchial wall thickening and emphysema but decreased with air trapping. In a previously healthy occupational cohort, high-intensity WTC exposure increased the risk for CT abnormalities. Bronchial wall thickening and emphysema were associated with respiratory symptoms, accelerated FEV1 decline, and airflow obstruction. Air trapping was associated with respiratory symptoms, although lung function was preserved. Physiologic differences between CT abnormalities suggest that distinct types of airway injury may result from a common exposure.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Abnormalities on Chest Computed Tomography and Lung Function Following an Intense Dust Exposure: A 17-Year Longitudinal Study

Liu

Putman

Singh

et al. 2019

IJERPH

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“… 16 , 17 However, the application of CT in “small airway disease” is still limited to the bronchus of moderate size at generation six or above. 18 , 19 There is restricted straightforward data on the real small airway, the conductive bronchi with an internal diameter <2 mm in the CT study.…”

Section: Introductionmentioning

confidence: 99%

Quantitative CT Analysis of Small Airway Remodeling in Patients with Chronic Obstructive Pulmonary Disease by a New Image Post-Processing System

Qin

Li³

et al. 2021

COPD

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“…Among individuals with COPD, the presence of such exposures was associated with a higher burden of respiratory symptoms, decreased exertional capacity and a higher incidence of moderate and severe COPD exacerbations. Furthermore, occupational exposures were also associated with radiographic abnormalities on chest computed tomography (CT) including airways disease, air trapping and emphysema 13 . These findings highlight the importance of obtaining a thorough occupational history both in individuals with newly diagnosed and previously established COPD.…”

Section: Exposuresmentioning

confidence: 99%

Insights into Chronic Obstructive Pulmonary Disease Epidemiology, Phenotypes and Outcomes from SPIROMICS

Labaki¹,

Martínez²,

Han³

2021

BRN

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SubPopulations and InteRmediate Outcome Measures in COPD Study (SPIROMICS) is a multicentre National Institutes of Health funded cohort study of nearly 3000 never-smokers and ever-smokers (≥ 20 pack-years) with and without chronic obstructive pulmonary disease (COPD). It was designed to help fill gaps in our understanding of the biological complexity and clinical heterogeneity of COPD. The original goals for this study were to identify subgroups of smokers who may benefit from targeted therapies and to discover and validate intermediate biomarker endpoints. Here we review important findings from SPIROMICS over the past five years, including the impact of environmental and occupational exposures on the respiratory health of smokers, the characterisation of symptomatic smokers with preserved pulmonary function and the investigation of several diagnostic and prognostic biomarkers such as airway mucin concentration, functional small airways disease on chest computed tomography and a gene expression signature of interleukin 17A response in airway epithelium.

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Occupational Exposures and Computed Tomographic Imaging Characteristics in the SPIROMICS Cohort

Abstract: Rationale: Quantitative computed tomographic (CT) imaging can aid in chronic obstructive pulmonary disease (COPD) phenotyping. Few studies have identified whether occupational exposures are associated with distinct CT imaging characteristics.

Cited by 29 publications

References 43 publications

Abnormalities on Chest Computed Tomography and Lung Function Following an Intense Dust Exposure: A 17-Year Longitudinal Study

Abnormalities on Chest Computed Tomography and Lung Function Following an Intense Dust Exposure: A 17-Year Longitudinal Study

Quantitative CT Analysis of Small Airway Remodeling in Patients with Chronic Obstructive Pulmonary Disease by a New Image Post-Processing System

Insights into Chronic Obstructive Pulmonary Disease Epidemiology, Phenotypes and Outcomes from SPIROMICS

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