“…Other forms of amorphous silica, including precipitated and pyrogenic silicas, generally have not been linked to silicosis in humans (Volk, 1960;Plunkett & DeWitt, 1962;Wilson et al, 1979;Choudat et al, 1990), although x-ray abnormalities and reduced pulmonary function have been reported among workers exposed to pyrogenic silicas in a metallurgical plant (Vitums et al, 1977). In this study, confounding by other agents, including cristobalite and cigarette smoking, was Legge, 1932Vigliani, 1948Motley, 1956Cooper, 1958Cooper, 1977Cooper, 1984Motley, 1960Volk, 1960Plunkett, 1962 Cross-sectional survey Cross-sectional survey Normal to mild reduction in pulmonary function Pneumoconiosis in 46% of workers exposed to calcined diatomite No pneumoconiosis in workers exposed to crude diatomite only All but 2 of 1 3 long-term (20+ yr) workers with pneumoconiosis were exposed to calcined diatomite Pneumoconiosis incidence decreased with reduced dust level, with nearly all cases employed before 1953 All 11 workers with pneumoconiosis were employed for more than 25 yr Higher concentration of amorphous silica particles in bronchoalveolar lavage fluid of blast-furnace workers than white-collar workers o not considered.…”