Occupational exposure to hexavalent chromium and cancers of the gastrointestinal tract: A meta-analysis

Gatto, Nicole M.; Kelsh, Michael A.; Ha, Diem; Suh, Mina; Proctor, Deborah M.

doi:10.1016/j.canep.2010.03.013

Cited by 75 publications

(52 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cr(VI) compounds, which may be found in the diet, can interact directly with DNA of gastric mucosa [67] and modify the expression of genes involved in cancer induction [68], but its carcinogenic potential when orally ingested remains controversial [69,70]. De Flora et al [71] administered sodium dichromate to mice for 9 consecutive months, at doses corresponding to 5 and 20 mg Cr(VI)/l.…”

Section: A B C Dmentioning

confidence: 99%

Oxidative Stress Markers and Histological Analysis in Diverse Organs from Rats Treated with a Hepatotoxic Dose of Cr(VI): Effect of Curcumin

García-Niño

Zatarain-Barrón

Hernández-Pando

et al. 2015

Biol Trace Elem Res

View full text Add to dashboard Cite

Hexavalent chromium [Cr(VI)] compounds are extremely toxic and carcinogenic. Despite the vast quantity of reports about Cr(VI) toxicity, the information regarding its effects when it is intraperitoneally (i.p.) administered is still limited. In contrast, it has been shown that curcumin prevents hepatotoxicity induced by a single intraperitoneal injection of 15 mg/kg body weight (b.w.) of potassium dichromate (K2Cr2O7). This study aims to evaluate oxidative stress markers, the activity of antioxidant enzymes, and the potential histological injury in brain, heart, lung, kidney, spleen, pancreas, stomach, and intestine from rats treated with a hepatotoxic dose of K2Cr2O7 (15 mg/kg b.w.), and the effect of curcumin pretreatment. Rats were divided into four groups: control, curcumin, K2Cr2O7, and curcumin+K2Cr2O7. At the end of the treatment, plasma and ascites fluid were collected and target organs were dissected out for biochemical and histological analysis. K2Cr2O7 induced hepatotoxicity but failed to induce in all the other studied organs either oxidative or histological injury, since levels of malondialdehyde (MDA), glutathione (GSH), and the activity of superoxide dismutase (SOD), catalase (CAT), and related GSH enzymes were unchanged. As expected, curcumin was safe. Lack of K2Cr2O7-induced toxicity in those target organs could be due to the following: (1) route of administration, (2) absorption through the portal circulation, (3) lower dose than needed, (4) short time of exposure, or (5) repeated doses are required to produce damage. Thus, the intraperitoneal injection of 15 mg/kg of K2Cr2O7, that is able to induce hepatotoxicity, was unable to induce histological and oxidative damage in other target organs.

show abstract

Section: A B C Dmentioning

confidence: 99%

Oxidative Stress Markers and Histological Analysis in Diverse Organs from Rats Treated with a Hepatotoxic Dose of Cr(VI): Effect of Curcumin

García-Niño

Zatarain-Barrón

Hernández-Pando

et al. 2015

Biol Trace Elem Res

View full text Add to dashboard Cite

show abstract

“…Finally, we included 80 papers for this overview of reviews, but in our article we only reviewed 55 etiological SRs/meta-analyses (Fu et al, 1995;Huang et al, 1998;Jacobs et al, 1998;Danesh et al, 1999;Eslick et al, 1999;Jia et al, 2000;Wu et al, 2000;Xue et al, 2001;Huang et al, 2003;Guo et al, 2004;Li et al, 2004;Botelho et al, 2006;Hu et al, 2006;Jakszyn et al, 2006;Liu et al, 2006;MacLean et al, 2006;Nishino et al, 2006;Tian et al, 2006;Xu et al, 2006;An et al, 2007;Kubo et al, 2007;Lunet et al, 2007;Merrill et al, 2007;Bae et al, 2008;Ladeiras-Lopes et al, 2008;Kuoppala et al, 2008;Shimazu et al, 2008;Zhou et al, 2008;Huang et al, 2009;La Torre et al, 2009;Mulholland et al, 2009;Myung et al, 2009;Yang et al, 2009;Zhang et al, 2009;Cavaleiro-Pinto et al, 2010;Gatto et al, 2010;Hussein et al, 2010;Kang et al, 2010;Kim et al, 2010;…”

Section: Search Resultsmentioning

confidence: 99%

Overview of Methodological Quality of Systematic Reviews about Gastric Cancer Risk and Protective Factors

Ying²,

Sun³

et al. 2012

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Background and Objective: A comprehensive overall review of gastric cancer (GC) risk and protective factors is a high priority, so we conducted the present study. Methods: Systematic searches in common medical electronic databases along with reference tracking were conducted to include all kinds of systematic reviews (SRs) about GC risk and protective factors. Two authors independently selected studies, extracted data, and evaluated the methodological qualities and the quality of evidence using R-AMSTAR and GRADE approaches. Results: Betacarotene below 20 mg/day, fruit, vegetables, non-fermented soy-foods, whole-grain, and dairy product were GC protective factors, while beta-carotene 20 mg/day or above, pickled vegetables, fermented soy-foods, processed meat 30g/d or above, or salty foods, exposure to alcohol or smoking, occupational exposure to Pb, overweight and obesity, helicobacter pylori infection were GC risk factors. So we suggested screening and treating H. pylori infection, limiting the amount of food containing risk factors (processed meat consumption, beta-carotene, pickled vegetables, fermented soy-foods, salty foods, alcohol), stopping smoking, avoiding excessive weight gain, avoidance of Pb, and increasing the quantity of food containing protective components (fresh fruit and vegetables, non-fermented soy-foods, whole-grain, dairy products). Conclusions: The conclusions and recommendations of our study were limited by including SRs with poor methodological bases and low quality of evidence, so that more research applying checklists about assessing the methodological qualities and reporting are needed for the future.

show abstract

“…Cr(VI) enters the body through the lungs and gastrointestinal tract, and to a lesser extent through the skin. Exposure to this agent can lead to severe respiratory, cardiovascular, gastrointestinal, hepatic, and renal damage (3)(4)(5)(6). Cytotoxicity and genotoxicity of Cr(VI) in humans has been reported (7).…”

Section: Introductionmentioning

confidence: 99%

“…Chronic exposure to high concentrations of Cr(VI) in drinking water causes intestinal adenomas and carcinomas in mice. Cr(VI) produces damage to intestinal villi and crypt hyperplasia in mice after only one week of exposure (3,4). Kumar and Gangwar (2012) reported that Cr(VI) produced injuries in the liver and kidney (8).…”

Section: Introductionmentioning

confidence: 99%

Effect of Simvastatin on Sodium Dichromate-Induced Lung Injury in Rats

Goodarzi¹,

Karami²,

Ahmadizadeh³

2016

Jundishapur J Nat Pharm Prod

View full text Add to dashboard Cite

show abstract

Occupational exposure to hexavalent chromium and cancers of the gastrointestinal tract: A meta-analysis

Cited by 75 publications

References 43 publications

Oxidative Stress Markers and Histological Analysis in Diverse Organs from Rats Treated with a Hepatotoxic Dose of Cr(VI): Effect of Curcumin

Oxidative Stress Markers and Histological Analysis in Diverse Organs from Rats Treated with a Hepatotoxic Dose of Cr(VI): Effect of Curcumin

Overview of Methodological Quality of Systematic Reviews about Gastric Cancer Risk and Protective Factors

Effect of Simvastatin on Sodium Dichromate-Induced Lung Injury in Rats

Contact Info

Product

Resources

About