Occupational Exposure to Dusts, Gases, and Fumes and Incidence of Chronic Obstructive Pulmonary Disease in the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults

Mehta, Amar; Malka, David; Keidel, Dirk; Bettschart, Robert; Bircher, Andreas J.; Bridevaux, Pierre‐Olivier; Ivan, Cristina; Kromhout, Hans; Rochat, Thierry; Rothe, Thomás; Russi, Erich W.; Schikowski, Tamara; Schindler, Christian; Schwartz, Joel; Turk, Alexander; Vermeulen, Roel; Probst‐Hensch, Nicole; Künzli, Nino

doi:10.1164/rccm.201110-1917oc

Cited by 152 publications

(125 citation statements)

References 34 publications

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“…GOLD criteria II+ was the most prevalent (92)(93)(94)(95). The FEV 1 and FEV 1 /FVC were the outcome in two studies (91,97), like FEV 1 /FVC<0.7 and <LLN (96,98). All eight studies found an association between airway obstruction/COPD and occupational exposure.…”

Section: Publications Since the Initial Reviewmentioning

confidence: 93%

Section: Publications Since the Initial Reviewmentioning

confidence: 99%

“…Five of these (91)(92)(93)(94)(95) were cross-sectional and three (96)(97)(98) were longitudinal with a follow-up time between 5-13 years. Six studies came from Europe (91,92,94,(96)(97)(98) and one study each from the US (93) and South Africa (95). Three of the studies (91,92,96) focused on inorganic exposure (cement production and metal melting), one (97) analyzed the association between organic exposure (dairy farming) and COPD, while four studies (93)(94)(95)98) were population-based.…”

Section: Publications Since the Initial Reviewmentioning

confidence: 99%

“…Six studies came from Europe (91,92,94,(96)(97)(98) and one study each from the US (93) and South Africa (95). Three of the studies (91,92,96) focused on inorganic exposure (cement production and metal melting), one (97) analyzed the association between organic exposure (dairy farming) and COPD, while four studies (93)(94)(95)98) were population-based. These studies comprised a total of 28 618 subjects.…”

Section: Publications Since the Initial Reviewmentioning

confidence: 99%

“…These studies comprised a total of 28 618 subjects. JEM alone defined exposure in four studies (91,95,96,98); JEM with personal sampling technique was employed in one study (91), and JEM with questionnaire data in two studies (95,98). The exposure was solely characterized by self-report in three studies (93,94,97) and one study defined exposure by area sampling (92).…”

Section: Publications Since the Initial Reviewmentioning

confidence: 99%

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Occupational chronic obstructive pulmonary disease: a systematic literature review

Omland

Würtz

Aasen³

et al. 2013

Scand J Work Environ Health

117

100

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Occupational chronic obstructive pulmonary disease: a systematic literature review by Omland Ø, Würtz ET, Aasen TB, Blanc P, Brisman J, Miller MR, Pedersen OF, Schlünssen V, Sigsgaard T, Ulrik CS, Viskum S This review on occupational chronic obstructive pulmonary disease (COPD) addresses some of the potential limitations of earlier assessments by restricting the studies included to high quality epidemiological analysis involving only spirometrically confirmed air-flow obstruction as the outcome. The authors combined this with minimal requirements for exposure characterization allowing for analysis of population-based studies. Affiliation 19Review Scand J Work Environ Health. 2014;40(1):19-35. doi:10.5271/sjweh.3400 Occupational chronic obstructive pulmonary disease: a systematic literature review Objective Occupational-attributable chronic obstructive pulmonary disease (COPD) presents a substantial health challenge. Focusing on spirometric criteria for airflow obstruction, this review of occupational COPD includes both population-wide and industry-specific exposures.Methods We used PubMed and Embase to identify relevant original epidemiological peer-reviewed articles, supplemented with citations identified from references in key review articles. This yielded 4528 citations. Articles were excluded for lack of lung function measurement, insufficient occupational exposure classification, lack of either external or internal referents, non-accounting of age or smoking effect, or major analytic inadequacies preventing interpretation of findings. A structured data extraction sheet was used for the remaining 147 articles. Final inclusion was based on a positive qualitative Scottish Intercollegiate Guidelines Network (SIGN) score (≥2+) for study quality, yielding 25 population-wide and 34 industry/occupation-specific studies, 15 on inorganic and 19 on organic dust exposure, respectively. ResultsThere was a consistent and predominantly significant association between occupational exposures and COPD in 22 of 25 population-based studies, 12 of 15 studies with an inorganic/mineral dust exposure, and 17 of 19 studies on organic exposure, even though the studies varied in design, populations, and the use of measures of exposure and outcome. A nearly uniform pattern of a dose-response relationship between various exposures and COPD was found, adding to the evidence that occupational exposures from vapors, gas, dust, and fumes are risk factors for COPD. ConclusionThere is strong and consistent evidence to support a causal association between multiple categories of occupational exposure and COPD, both within and across industry groups.Key terms: airflow obstruction; COPD; dust; fume; gas; lung function measurement; occupational exposure; vapor. Chronic obstructive pulmonary disease (COPD) represents serious morbidity and has emerged as a leading cause of death worldwide (1). Although tobacco smoking is the leading factor in the etiology of COPD, the disease may be caused by inhalation of different gases and aerosols among bot...

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Section: Publications Since the Initial Reviewmentioning

confidence: 93%

Section: Publications Since the Initial Reviewmentioning

confidence: 99%

Section: Publications Since the Initial Reviewmentioning

confidence: 99%

Section: Publications Since the Initial Reviewmentioning

confidence: 99%

Section: Publications Since the Initial Reviewmentioning

confidence: 99%

See 3 more Smart Citations

Occupational chronic obstructive pulmonary disease: a systematic literature review

Omland

Würtz

Aasen³

et al. 2013

Scand J Work Environ Health

117

100

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Association of Long-term Ambient Ozone Exposure With Respiratory Morbidity in Smokers

et al. 2020

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for SPIROMICS investigators IMPORTANCE Few studies have investigated the association of long-term ambient ozone exposures with respiratory morbidity among individuals with a heavy smoking history.OBJECTIVE To investigate the association of historical ozone exposure with risk of chronic obstructive pulmonary disease (COPD), computed tomography (CT) scan measures of respiratory disease, patient-reported outcomes, disease severity, and exacerbations in smokers with or at risk for COPD.

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A case‐control study of airways obstruction among construction workers

Dement

Welch

Quinn

et al. 2015

American J Industrial Med

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BackgroundWhile smoking is the major cause of chronic obstructive pulmonary disease (COPD), occupational exposures to vapors, gases, dusts, and fumes (VGDF) increase COPD risk. This case‐control study estimated the risk of COPD attributable to occupational exposures among construction workers.MethodsThe study population included 834 cases and 1243 controls participating in a national medical screening program for older construction workers between 1997 and 2013. Qualitative exposure indices were developed based on lifetime work and exposure histories.ResultsApproximately 18% (95%CI = 2–24%) of COPD risk can be attributed to construction‐related exposures, which are additive to the risk contributed by smoking. A measure of all VGDF exposures combined was a strong predictor of COPD risk.ConclusionsConstruction workers are at increased risk of COPD as a result of broad and complex effects of many exposures acting independently or interactively. Control methods should be implemented to prevent worker exposures, and smoking cessation should be promoted. Am. J. Ind. Med. 58:1083–1097, 2015. © 2015 The Authors. American Journal of Industrial Medicine Published by Wiley Periodicals, Inc.

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Occupational Exposure to Dusts, Gases, and Fumes and Incidence of Chronic Obstructive Pulmonary Disease in the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults

Abstract: In a Swiss working adult population, occupational exposures to biological dusts, mineral dusts, gases/fumes, and VGDF were associated with incidence of COPD of at least moderate severity.

Cited by 152 publications

References 34 publications

Occupational chronic obstructive pulmonary disease: a systematic literature review

Occupational chronic obstructive pulmonary disease: a systematic literature review

Association of Long-term Ambient Ozone Exposure With Respiratory Morbidity in Smokers

A case‐control study of airways obstruction among construction workers

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