Occupational exposure to chemicals and reproductive health

Taskinen, Helena; Lindbohm, Marja-Liisa; Sallmén, Markku

doi:10.1016/b978-0-12-382032-7.10072-4

Cited by 6 publications

(4 citation statements)

References 128 publications

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“…Many environmental and occupational chemicals are harmful to reproductive function and fertility (Cherry et al, 2008; Taskinen et al, 2011). Lead stands out as an environmental and occupational chemical agent.…”

Section: Introductionmentioning

confidence: 99%

Clomiphene citrate ameliorated lead acetate-induced reproductive toxicity in male Wistar rats

Oyeyemi

Princely

Akinola

et al. 2019

JBRA Assisted Reproduction

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Objective:The current study investigated the effects of clomiphene citrate on the hypothalamic-pituitary-testicular axis, steroidogenesis, sperm parameters, and testicular antioxidant enzyme activity of male Wistar rats submitted to lead acetate (Pb)-induced reproductive toxicity. Methods:Twenty adult male Wistar rats were divided into four groups of equal size as follows: Control; Clomid (0.35 mg/kg); Pb (10 mg/kg); and Clomid + Pb. Serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone, testicular 17-β hydroxysteroid dehydrogenase (17-β HSD) activity, androgen receptors, catalase activity, superoxide dismutase (SOD), malondialdehyde (MDA), sperm motility, viability, counts and morphology were estimated after oral administration of Clomid and/or lead acetate for 35 consecutive days. Data were analyzed using ANOVA at p<0.05.Results:Lead acetate significantly decreased (p<0.05) serum LH and testosterone levels, testicular 17β-HSD activity, androgen receptor expression, sperm motility, viability, counts, catalase activity, and SOD when compared with controls. Abnormal sperm morphology and MDA were significantly increased (p<0.05) in the Pb group compared with controls. Clomid co-administrated with lead acetate significantly increased (p<0.05) serum LH, testosterone levels, testicular 17β-HSD, androgen receptor expression, sperm motility and viability when compared with the group given lead acetate.Conclusions:The present study suggests that clomiphene citrate may stimulate testicular testosterone synthesis, sperm motility and viability via luteinizing hormone in a context of lead acetate-induced reproductive toxicity.

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Section: Introductionmentioning

confidence: 99%

Clomiphene citrate ameliorated lead acetate-induced reproductive toxicity in male Wistar rats

Oyeyemi

Princely

Akinola

et al. 2019

JBRA Assisted Reproduction

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“…Previous studies have shown that male exposure to lead is associated with reduced fertility in couples and adverse pregnancy outcomes (Taskinen et al, 2011) and increased risk of childhood leukemia (Miligi et al, 2013). Furthermore, some animal studies offer evidence of behavioral effects of paternal lead exposure.…”

Section: Discussionmentioning

confidence: 97%

“…During the 1960s and 1970s, the acute and chronic effects of Pb exposure on male fertility became a concern for occupational health and safety (Anttila, 1994). Male lead exposure was linked in some studies to prolonged time to pregnancy, reduced fertility rate and adverse pregnancy outcomes (reviewed by Bellinger, 2005, Taskinen et al, 2011.…”

Section: Introductionmentioning

confidence: 98%

Paternal occupational lead exposure and offspring risks for schizophrenia

Sallmén

Suvisaari

Lindbohm

et al. 2016

Schizophrenia Research

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“…Exposure to pesticides occurs especially in agriculture and the chemical industry, although all persons working or living on farms may also be exposed. Occupational exposure to xenoestrogens occurs primarily in people working in the production of plastics (bisphenol A, phthalates), epoxy resins, or in the metallurgy and metal processing sectors, and industries that require welding and soldering (especially metalloestrogens -cadmium, mercury, arsenic, iron) [23].…”

Section: Methodsmentioning

confidence: 99%

The impact of xenoestrogens on effectiveness of treatment for hormone-dependent breast cancer – current state of knowledge and perspectives for research

Boszkiewicz¹,

Sawicka²,

Piwowar³

2020

Ann Agric Environ Med.

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Introduction. Breast cancer is the most common cancer occurring in women and causing the highest number of deaths among them. The role of xenoestrogens has been the subject of many studies in the pathogenesis of breast cancer. Less is known about the impact of xenoestrogens on the effectiveness of hormone therapy used to treat breast cancer, and thus possible drug-xenostrogen interactions. Objective. The aim of this review is to summarize the current state of knowledge and present perspectives for further research on the impact of xenoestrogens on the effectiveness of drugs used in the treatment of hormone-dependent breast cancer. Current state of knowledge. Phytoestrogens, in particular flavonoid genistein, are the best studied group of xenoestrogens in terms of interaction with drugs used in the treatment of breast cancer, due to their frequent use, including their use in alleviating the adverse effects of hormone therapy. Analyzing the current state of knowledge, it seems that phytoestrogens intake should be avoided during conventional anti-cancer treatment. Of the other xenoestrogens, bisphenol A (BPA) is one of the best-tested compounds for interactions with drugs used to treat breast cancer. It has been shown that bisphenol A could reduced therapeutic effect of active tamoxifen metabolite and cytostatics used in breast cancer treatment. Conclusion. Confirmation in clinical trials of the results obtained in vitro and in vivo tests, would enable the creation of specific recommendations for patients undergoing breast cancer treatment, especially hormone therapy. An area requiring further research is the analysis of the effects of xenoestrogens other than phytoestrogens, e.g. metalloestrogens, on the effects of drugs used in the treatment of breast cancer.

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Occupational exposure to chemicals and reproductive health

Cited by 6 publications

References 128 publications

Clomiphene citrate ameliorated lead acetate-induced reproductive toxicity in male Wistar rats

Clomiphene citrate ameliorated lead acetate-induced reproductive toxicity in male Wistar rats

Paternal occupational lead exposure and offspring risks for schizophrenia

The impact of xenoestrogens on effectiveness of treatment for hormone-dependent breast cancer – current state of knowledge and perspectives for research

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