Occupational Exposure Monitoring Using Breath Analysis

Droz, Pierre‐Olivier; Guillemin, Michel

doi:10.1097/00043764-198608000-00014

Cited by 62 publications

(37 citation statements)

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“…Thus the error of measurement should contribute only about one-fourth of the total variation observed in the breath samples when s\, w reflects the variability in breath measurements within individuals, which is associated with short-term variation in exposure. If this method were applied to breath concentrations at the beginning of work, following 16 h of nonexposure, then s\.w would result from the presumably smaller variation in exposure which occurs over longer periods (1). Then s\.w would contribute between about one-fourth and onehalf of the total variance.…”

Section: Partitioning the Variability Of Breath Measurementsmentioning

confidence: 99%

A field method for measuring solvent vapors in exhaled air--application to styrene exposure.

Rappaport¹,

Kure²,

Petreas³

et al. 1991

Scand J Work Environ Health

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Section: Partitioning the Variability Of Breath Measurementsmentioning

confidence: 99%

A field method for measuring solvent vapors in exhaled air--application to styrene exposure.

Rappaport¹,

Kure²,

Petreas³

et al. 1991

Scand J Work Environ Health

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“…Several urinary metabolite assays are available but these methods generally lack sensitivity and/or specificity when applied to environmental exposures. However, breath sampling of VOCs is a valid method for evaluating environmental exposure (32,33). This methodology is especially well suited for children because of its noninvasiveness and ease with which samples can be collected.…”

Section: Application Of Biomarker Study Designs For Childrenmentioning

confidence: 99%

Approaches to environmental exposure assessment in children.

Weaver

Buckley

Groopman

1998

Environ Health Perspect

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An improved understanding of the contribution made by environmental exposures to disease burden in children is essential, given current increasing rates of childhood illnesses such asthma and cancer. Children must be routinely included in environmental research. Exposure assessment, both external (e.g., air, water) and internal dose (e.g., biomarkers), is an integral component of such research. Biomarker measurement has some advantages that are unique in children. These include assessment of potentially increased absorption because of behaviors that differ from adults (i.e., hand-to-mouth activity); metabolite measurement, which can help identify age-related susceptibility differences; and improved assessment of dermal exposure, an important exposure route in children. Environmental exposure assessment in children will require adaption of techniques that are currently applied in adult studies as well as development of tools and validation of strategies that are unique for children. Designs that focus on parent-child study units provide adult comparison data and allow the parent to assist with more complex study designs. Use of equipment that is sized appropriately for children, such as small air pumps and badge monitors, is also important. When biomarkers are used, biologic specimens that can be obtained noninvasively are preferable. Although the current need is primarily for small focused studies to address specific questions and optimize research tools, the future will require establishment of large prospective cohorts. Urban children are an important study cohort because of relatively high morbidity observed in the urban environment. Finally, examples of completed or possible future studies utilizing these techniques are discussed for specific exposures such as benzene, environmental tobacco smoke, aflatoxin, volatile organic compounds, and polycyclic aromatic hydrocarbons. -Environ Health Perspect 106(Suppl 3):827-832 (1998).

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“…The technique has recently been brought into prominence by its incorporation into the biological exposure indices of threshold limit values (8). An extensive review of the procedures , applications, and limitations of breath sampling was recently presented in the literature (12). This approach offers a noninvasive way to estimate the uptake of solvents through inhalation.…”

Section: Cyclohexanone In Exhaled Breathmentioning

confidence: 99%

“…Through measurements of exhaled breath at the end of exposure, it is theoret ically possible to estimate the amount of material that is present in the body (12). However, the main setback for breath analysis is that the results can vary considerably, depending on the type of sampling technique and the time of sampling.…”

Section: Cyclohexanone In Exhaled Breathmentioning

confidence: 99%

“…However, the main setback for breath analysis is that the results can vary considerably, depending on the type of sampling technique and the time of sampling. Breath analysis reflects the uptake accurately provided 5 that the exposure was relatively constant over the work period, but in field situations the exposure usually varies throughout the day (12). There are several other factors that may also affect breath analysis -the solubility of the solvent in blood, metabolic clearance, cigarette smoking, absorption from other routes, and the vital capacit y of the lung (12,13).…”

Section: Cyclohexanone In Exhaled Breathmentioning

confidence: 99%

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