Occupational exposure and severe pulmonary fibrosis

Gustafson, T.; Dahlman-Höglund, Anna; Nilsson, Kenneth; Ström, Kerstin; Tornling, Göran; Torén, Kjell

doi:10.1016/j.rmed.2007.02.027

Cited by 66 publications

(49 citation statements)

References 24 publications

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“…Increased risk for IPF has been found to be associated with a variety of environmental exposures (22,26,27,30,(32)(33)(34). A significantly increased risk has been observed after exposure to metal dusts (brass, lead, and steel) and wood dust (pine) (26, 30, 33) Farming, raising birds, hair dressing, stone cutting/polishing, and exposure to livestock and to vegetable dust/animal dust have also been associated with IPF (27).…”

Section: Potential Risk Factorsmentioning

confidence: 99%

An Official ATS/ERS/JRS/ALAT Statement: Idiopathic Pulmonary Fibrosis: Evidence-based Guidelines for Diagnosis and Management

Raghu¹,

Collard²,

Egan³

et al. 2011

Am J Respir Crit Care Med

6,226

7,347

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Section: Potential Risk Factorsmentioning

confidence: 99%

An Official ATS/ERS/JRS/ALAT Statement: Idiopathic Pulmonary Fibrosis: Evidence-based Guidelines for Diagnosis and Management

Raghu¹,

Collard²,

Egan³

et al. 2011

Am J Respir Crit Care Med

6,226

7,347

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“…The Swedevox register covers 85% of all patients starting LTOT in Sweden 13. Details of the study design and a previous analysis using the same dataset have been published 14. Data were collected through an extensive postal questionnaire on smoking, occupational exposure (including fibres, fumes, gas, mineral dust, organic dust and vapours) and diagnosis of PF.…”

Section: Methodsmentioning

confidence: 99%

Effects of smoking, gender and occupational exposure on the risk of severe pulmonary fibrosis: a population-based case-control study

et al. 2014

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ObjectivesTo estimate the effects of smoking, gender and occupational exposure on the risk of developing severe pulmonary fibrosis (PF), including dose-response and interaction effects.MethodsNational case–control study of 171 patients (cases) who had started a long-term oxygen therapy for PF in Sweden between February 1997 and April 2000, and 719 random control participants from the general population. Of these cases, 137 had probable idiopathic PF (IPF). The ORs for smoking, gender and occupational exposure were estimated using Mantel-Haenszel analysis and conditional logistic regression, controlling for age and year of diagnosis.ResultsThe adverse effect of smoking was amplified by male gender and occupational exposure, OR 4.6 (95% CI 2.1 to 10.3) for PF, and OR 3.0 (1.3 to 6.5) for IPF, compared with in non-exposed women. Higher cumulative smoking exposure was linearly associated with increased risks. Compared with smoking less than 10 pack-years, smoking ≥20 pack-years was associated with increased risk of PF and IPF, OR 2.6 (1.4 to 4.9) and OR 2.5 (1.3 to 5.0), respectively.ConclusionsSmoking has a dose-related association with increased risk of severe PF. Men with a history of smoking and occupational exposure is a particular risk group for developing severe PF.

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“…Despite the progress made in various therapeutic modalities, the overall outcome of patients with lung cancer, especially those with small cell lung cancer (SCLC), remains poor and has not decreased to a level with which we can be satisfied [2,3]. Cigarette smoking and occupational exposures are common contributors not only to SCLC but also to interstitial lung disease (ILD) such as idiopathic pulmonary fibrosis (IPF) [4,5]. Collagen disease-associated pulmonary fibrosis (CDPF) and IPF are the most common ILDs.…”

Section: Introductionmentioning

confidence: 99%

Interstitial lung disease in patients with small cell lung cancer

et al. 2009

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Interstitial lung disease (ILD) and lung cancer are two of the most common respiratory diseases. The aim of this study was to demonstrate the prognostic significance of the presence of ILD in patients with small cell lung cancer (SCLC). All the patients with SCLC who were admitted to our hospitals over a 23-year period up to 2008 were retrospectively analyzed. During the study period, 332 SCLC patients were consecutively admitted to our hospitals. Among them, 15 (4.5%) were diagnosed as having both SCLC and ILD. In univariate and multivariate analysis, female sex, early stage, good performance status, and chemotherapy were favorable prognostic factors. The presence of ILD was confirmed as an unfavorable prognostic factor. Existing ILD adversely affects the outcome of SCLC. When deciding whether to offer a standard therapy that may increase treatment-related mortality, the patient's medical condition, including ILD, should be taken into consideration.

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Occupational exposure and severe pulmonary fibrosis

Abstract: Exposure for birch and hardwood dust may contribute to the risk for IPF in men.

Cited by 66 publications

References 24 publications

An Official ATS/ERS/JRS/ALAT Statement: Idiopathic Pulmonary Fibrosis: Evidence-based Guidelines for Diagnosis and Management

An Official ATS/ERS/JRS/ALAT Statement: Idiopathic Pulmonary Fibrosis: Evidence-based Guidelines for Diagnosis and Management

Effects of smoking, gender and occupational exposure on the risk of severe pulmonary fibrosis: a population-based case-control study

Interstitial lung disease in patients with small cell lung cancer

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