Occupational contact dermatitis in the pharmaceutical industry

Goossens, An; Hulst, Kim Vander

doi:10.1016/j.clindermatol.2011.08.011

Cited by 14 publications

(5 citation statements)

References 117 publications

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“…Studies suggest an inverse relationship between psoriasis and contact sensitization, presumably due to impaired reactivity towards allergens common for autoimmune diseases 9 . The presented case continues to indicate high risk of open technological processes in drug production for development of occupational airborne ACD, and adds saxagliptin as a new occupational contact allergen to the already long list of drugs with that same effect 10 …”

Section: Discussionmentioning

confidence: 77%

Contact allergy to olanzapine and saxagliptin in a pharmaceutical industrial worker: A case report

Huršidić Radulović,

Babić,

Macan

et al. 2024

Contact Dermatitis

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Section: Discussionmentioning

confidence: 77%

Contact allergy to olanzapine and saxagliptin in a pharmaceutical industrial worker: A case report

Huršidić Radulović,

Babić,

Macan

et al. 2024

Contact Dermatitis

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“…İlaçlar deriye direk temasla ve /veya üretim aşamasındaki ara veya son ürünlerin aeroselleri aracılığıyla kontakt dermatitlere yol açabilirler (14). Örneğin azitromisin hem irritan hem allerjik ABKD'ye yol açtığı bildirilen ilaçlardan birisidir (15,16).…”

Section: I-mesleki Allerjik Abkdunclassified

Mesleksel Havayla Taşınan (Airborne) Kontakt Dermatitler

2015

Dermatoz

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ÖzetMesleksel Havayla Taşınan (Airborne) Kontakt Dermatitler Günümüzde sanayideki gelişmeler çok sayıda irritan ve allerjene mesleksel maruziyeti beraberinde getirmekte ve bu durum da mesleki dermatozlarda çeşitliliğe neden olmaktadır. Bunlardan birisi de Havayla Taşınan (Airborne) kontakt dermatit (ABKD) olarak tanımlanan; toz, sprey, polen ve uçucu kimyasalların duman veya partiküllerinin havayolu aracılığı ile deriye teması sonucu oluşan farklı bir kontakt dermatit formudur. ABKD'ler epidemiyolojik olarak mesleksel ve mesleksel olmayan olmak üzere ikiye ayrılmaktadır. Mesleksel olmayan ABKD'ler genellikle bitkisel kaynaklıdır. Mesleksel ABKD'lerden ise ilaçlar, dezenfektanlar, bitki ve ağaç ürünleri, plastikler, lastikler, yapıştırıcılar, metaller, insektisidler, pestisidler, solventler gibi çok sayıda irritan veya allerjik ajanlar sorumludur. Mesleksel ABKD tanı koyma aşamasındaki sorunlar nedeniyle hem hasta hem de doktor için büyük bir bulmacaya dönüşebilir. Bu yazıda mesleksel ABKD'lerin epidemiyolojik ve klinik özellikleri literatür bilgileri ışığında değerlendirilmiştir.Anahtar Kelimeler: Meslek hastalığı, mesleki dermatoz, airborne kontakt dermatit Abstract Occupational Airborne Contact DermatitisNowadays, industrial developments bring a large number of occupational irritant and allergen exposure and this situation is causing diversity in occupational dermatoses. One of them is airborne contact dermatitis (ABCD) which is a different form of contact dermatitis resulting from contact with powders, spray, pollen, and smoke of volatile chemicals or particles flying through the skin. ABCDs are epidemiologically divided into two groups; occupational and non-occupational. Non-occupational ABCDs are usually vegetable origin. A large number of allergens and irritants such as drugs, disinfectants, plant and wood products, plastics, rubber, adhesives, metals, insecticides, pesticides and solvents are responsible for occupational ABCD. Occupational ABCD because of problems at stage of diagnosis can turn into a big puzzle for both patient and doctor. In this article, the epidemiological and clinical characteristics of occupational ABCD were evaluated in the view of literature.

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“…Additionally, it can be used not only for hazard identification but also prediction of potency . The latter is important for occupational safety since relative potency can aid in the selection of a peptide coupler and the determination of appropriate occupational exposure controls, including containment technology, personal protective equipment (PPE), and the development and application of safe residual surface wipe limits. − As much as in silico modeling provided impetus for animal testing, LLNA results were subsequently used to inform changes in computational models. This interactive approach resulted in a horizontally integrated in vivo - in silico framework, which can be applied to reliably assess the dermal-sensitization hazard of novel peptide couplers.…”

Section: Introductionmentioning

confidence: 99%

An Evaluation of the Occupational Health Hazards of Peptide Couplers

Graham¹,

Trejo‐Martin

Chilton

et al. 2022

Chem. Res. Toxicol.

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Peptide couplers (also known as amide bond-forming reagents or coupling reagents) are broadly used in organic chemical syntheses, especially in the pharmaceutical industry. Yet, occupational health hazards associated with this chemical class are largely unexplored, which is disconcerting given the intrinsic reactivity of these compounds. Several case studies involving occupational exposures reported adverse respiratory and dermal health effects, providing initial evidence of chemical sensitization. To address the paucity of toxicological data, a pharmaceutical cross-industry task force was formed to evaluate and assess the potential of these compounds to cause eye and dermal irritation as well as corrosivity and dermal sensitization. The goal of our work was to inform health and safety professionals as well as pharmaceutical and organic chemists of the occupational health hazards associated with this chemical class. To that end, 25 of the most commonly used peptide couplers and five hydrolysis products were selected for in vivo, in vitro , and in silico testing. Our findings confirmed that dermal sensitization is a concern for this chemical class with 21/25 peptide couplers testing positive for dermal sensitization and 15 of these being strong/extreme sensitizers. We also found that dermal corrosion and irritation (8/25) as well as eye irritation (9/25) were health hazards associated with peptide couplers and their hydrolysis products (4/5 were dermal irritants or corrosive and 4/5 were eye irritants). Resulting outcomes were synthesized to inform decision making in peptide coupler selection and enable data-driven hazard communication to workers. The latter includes harmonized hazard classifications, appropriate handling recommendations, and accurate safety data sheets, which support the industrial hygiene hierarchy of control strategies and risk assessment. Our study demonstrates the merits of an integrated, in vivo - in silico analysis, applied here to the skin sensitization endpoint using the Computer-Aided Discovery and REdesign (CADRE) and Derek Nexus programs. We show that experimental data can improve predictive models by filling existing data gaps while, concurrently, providing computational insights into key initiating events and elucidating the chemical structural features contributing to adverse health effects. This interactive, interdisciplinary approach is consistent with Green Chemistry principles that seek to improve the selection and design of less hazardous reagents in industrial processes and applications.

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Occupational contact dermatitis in the pharmaceutical industry

Cited by 14 publications

References 117 publications

Contact allergy to olanzapine and saxagliptin in a pharmaceutical industrial worker: A case report

Contact allergy to olanzapine and saxagliptin in a pharmaceutical industrial worker: A case report

Mesleksel Havayla Taşınan (Airborne) Kontakt Dermatitler

An Evaluation of the Occupational Health Hazards of Peptide Couplers

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