Occupational contact dermatitis caused by isopropanol‐containing disinfectant based on a genetic defect

Galli-Novak, Evgenia; Wilfinger, Daniel; Takacs, Szandra; Riesenhuber, Gernot; Aberer, Werner

doi:10.1111/cod.13197

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…Caucasians can carry single-nucleotide polymorphisms (SNPs) at the ADH1B gene, and this has been demonstrated to contribute to irritant hand dermatitis in a Caucasian nurse. 9 ADH and ALDH are present in human skin. 10…”

Section: Discussionmentioning

confidence: 99%

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Irritant hand dermatitis to alcohol hand sanitisers in healthcare workers: Possible role of alcohol metabolism polymorphisms

Teo,

Lee,

White

et al. 2023

Contact Dermatitis

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Section: Discussionmentioning

confidence: 99%

“…Secondary alcohols, such as isopropyl alcohol, are metabolized to acetone, which as with acetaldehyde, can be irritant. Caucasians can carry single‐nucleotide polymorphisms (SNPs) at the ADH1B gene, and this has been demonstrated to contribute to irritant hand dermatitis in a Caucasian nurse 9 …”

Section: Discussionmentioning

confidence: 99%

Irritant hand dermatitis to alcohol hand sanitisers in healthcare workers: Possible role of alcohol metabolism polymorphisms

Teo,

Lee,

White

et al. 2023

Contact Dermatitis

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“…The dermatological problems according to our findings which is in turn backed by similar studies conducted in different countries of Europe and Asia. 11,13,20,21 It was revealed that respondents involved in printing works were more vulnerable to have dermatological problems than those involved in post printing works. This finding is supported by the results of similar studies conducted in the United Kingdom and North America.…”

Section: Discussionmentioning

confidence: 99%

An analysis on the relationship between safety measures and dermatological complaints among printing industry workers in Bangladesh

Khan MAH,

Hamajima N,

Kariya T

et al. 2024

ZHSWMCJ

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Background: Work-related skin diseases occupy approximately 50 percent of total occupational illnesses and areresponsible for an estimated 25 percent of all lost workdays globally in many industries including printing industries.This study aimed to reveal the characteristics of dermatological problems and safety measures among printing workersin Bangladesh. Materials and methods: A cross-sectional study was conducted among 196 conveniently sampledprinting workers from 51 factories in September 2018. Data were collected by face-to-face interviews using a semi-structured questionnaire. A logistic regression model was applied to estimate the risk factors for dermatologicalproblems. Results: Among 196 respondents 74.0% experienced dermatological problems after joining a printingjob. Only 30.1% of respondents were found using personal protective equipment (PPE). No use of PPE, barriercream, hand washing more than 4 times a day, and duty in the printing process had a significant association with skinproblems (P<0.001). In the printing process, the workers who handled papers, chemicals, and machines and wereinvolved in cleaning machinery had a higher prevalence of dermatological problems. Logistic regression analysisshowed a significant association of skin problems among printing workers in Bangladesh with male (OR 0.23; 95%CI 0.06–0.98), higher monthly salaries (OR 17.98; 95% CI 3.14–103.08) and shorter daily work hours (OR 0.01;95% CI 0.01–0.56). Conclusion: This study revealed a high prevalence of dermatological problems among printingworkers in Bangladesh. PPE usage, avoiding excessive hand washing, and hand cream would be helpful in avoidingdermatological problems among printing workers in Bangladesh.

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Contact sensitizations to disinfectants containing alcohols or quaternary ammonium compounds are rarely of clinical relevance

et al. 2021

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BackgroundThe use of disinfectants is part of the everyday life of people, especially in the medical profession. During the coronavirus disease 2019 (COVID‐19) pandemic, the use of disinfectants continues to increase and is of fundamental importance in infection control.ObjectivesTo determine the frequency of sensitization and the value of patch testing to didecyldimethylammonium chloride (DDAC) and the alcohols ethanol, 1‐propanol, and isopropanol.MethodsClinical patch test data of 145 patients with suspected contact allergy to disinfectants were retrospective analysed.ResultsAmong the 145 patients patch tested with the different alcohols, only one nurse was detected with a possible allergy to 1‐propanol. Additional patch testing in 84 patients with DDAC 0.05% resulted in five patients with weakly positive reactions only, without clinical relevance. Patch testing with DDAC 0.03% showed no positive reactions at all on day 3 readings.ConclusionsDDAC and alcohols are rarely responsible for allergic contact dermatitis. The accused products of the patients should be checked for other allergens and further additives with skin‐irritating properties. Individual susceptibility and mishandling of the disinfectants should be considered.

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Occupational contact dermatitis caused by isopropanol‐containing disinfectant based on a genetic defect

Cited by 3 publications

References 10 publications

Irritant hand dermatitis to alcohol hand sanitisers in healthcare workers: Possible role of alcohol metabolism polymorphisms

Irritant hand dermatitis to alcohol hand sanitisers in healthcare workers: Possible role of alcohol metabolism polymorphisms

An analysis on the relationship between safety measures and dermatological complaints among printing industry workers in Bangladesh

Contact sensitizations to disinfectants containing alcohols or quaternary ammonium compounds are rarely of clinical relevance

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