Occupational Complexity and Cognitive Reserve in a Middle-Aged Cohort at Risk for Alzheimer's Disease

Boots, Elizabeth A.; Schultz, Stephanie A.; Almeida, Risely Ferraz de; Oh, Jennifer M.; Koscik, Rebecca L.; Dowling, N. Maritza; Gallagher, Catherine L.; Carlsson, Cynthia M.; Rowley, Howard A.; Bendlin, Barbara B.; Asthana, Sanjay; Sager, Mark A.; Hermann, Bruce P.; Johnson, Sterling C.; Okonkwo, Ozioma C.

doi:10.1093/arclin/acv041

Cited by 111 publications

(123 citation statements)

References 35 publications

Supporting

Mentioning

116

Contrasting

Unclassified

Order By: Relevance

“…At the beginning, the concept of CR was developed in the context of aging and dementia. In chronic neurodegenerative conditions such as Alzheimer's disease, human immunodeficiency virus (HIV) or multiple sclerosis, it has been widely studied . Some questionnaires were created to measure the cognitive reserve of patients with dementia and of the general population, including the ‘cognitive reserve questionnaire’ , ‘CR Index questionnaire’ (CRIq) and ‘Cognitive Reserve Scale’ .…”

Section: Introductionmentioning

confidence: 99%

Cognitive reserve as an outcome predictor: first‐episode affective versus non‐affective psychosis

Amoretti

Cabrera

Torrent

et al. 2018

Acta Psychiatr Scand

View full text Add to dashboard Cite

CR plays a differential role in the outcome of psychoses according to the diagnosis. Specifically, in order to address the needs of non-affective patients with low CR, cognitive rehabilitation treatments will need to be 'enriched' by adding pro-cognitive pharmacological agents or using more sophisticated approaches. However, a functional remediation therapy may be of choice for those with an affective psychosis and low CR.

show abstract

Section: Introductionmentioning

confidence: 99%

Cognitive reserve as an outcome predictor: first‐episode affective versus non‐affective psychosis

Amoretti

Cabrera

Torrent

et al. 2018

Acta Psychiatr Scand

View full text Add to dashboard Cite

show abstract

“…1 Considerable focus has been placed on genetic and environmental risk factors that may play a role in progression to AD and are possibly targetable for intervention, including APOE e4, 2,3 physical activity, 4,5 and cognitive reserve. 6,7 Increasing evidence suggests that brain-derived neurotrophic factor (BDNF) may be a genetic risk factor for AD. BDNF is a neurotrophin known to play roles in synaptic plasticity, neurogenesis, neuronal survival, and cognitive health.…”

mentioning

confidence: 99%

BDNF Val66Met predicts cognitive decline in the Wisconsin Registry for Alzheimer's Prevention

et al. 2017

Self Cite

View full text Add to dashboard Cite

Objective: To examine the influence of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism on longitudinal cognitive trajectories in a large, cognitively healthy cohort enriched for Alzheimer disease (AD) risk and to understand whether b-amyloid (Ab) burden plays a moderating role in this relationship.Methods: One thousand twenty-three adults (baseline age 54.94 6 6.41 years) enrolled in the Wisconsin Registry for Alzheimer's Prevention underwent BDNF genotyping and cognitive assessment at up to 5 time points (average follow-up 6.92 6 3.22 years). A subset (n 5 140) underwent 11 C-Pittsburgh compound B (PiB) scanning. Covariate-adjusted mixed-effects regression models were used to elucidate the effect of BDNF on cognitive trajectories in 4 cognitive domains, including verbal learning and memory, speed and flexibility, working memory, and immediate memory. Secondary mixed-effects regression models were conducted to examine whether Ab burden, indexed by composite PiB load, modified any observed BDNF-related cognitive trajectories. Conclusions: In a middle-aged cohort with AD risk, carriage of the BDNF Met allele was associated with steeper decline in episodic memory and executive function. This decline was exacerbated by greater Ab burden. These results suggest that the BDNF Val66Met polymorphism may play an important role in cognitive decline and could be considered as a target for novel AD therapeutics. Results:

show abstract

“…The effects of modifiable risk factors on cross-sectional cognition have been the target of multiple WRAP investigations. Cognitive activity throughout the lifespan measured by education level [21], job complexity [51], and selfreported current participation in stimulating activities such as games [52,53], are associated with better performance in several cognitive domains. Participants with greater numbers of stressful life events perform worse on measures of cognitive speed and flexibility, and conversely, in participants with greater social support performance is better [54].…”

Section: Previous Findingsmentioning

confidence: 99%

The Wisconsin Registry for Alzheimer’s Prevention: A Review of findings and current directions

Johnson

Koscik

Jonaitis

et al. 2017

Preprint

Self Cite

156

View full text Add to dashboard Cite

The Wisconsin Registry for Alzheimer's Prevention (WRAP) is a longitudinal observational cohort study enriched with persons with a parental history (PH) of probable Alzheimer's Disease (AD) dementia. Since late 2001, WRAP has enrolled 1,561 people at a mean baseline age of 54. Participants return for a second visit four years after baseline and subsequent visits occur every two years. Eighty-one percent (1270) of participants remain active in the study at a current mean age of 64 and 9 years of follow-up. Serially assessed cognition, self-reported medical and lifestyle histories (e.g. diet, physical and cognitive activity, sleep, and mood), laboratory tests, genetics, and linked studies comprising molecular imaging, structural imaging and cerebrospinal fluid data, have yielded many important findings. In this cohort, PH of probable AD is associated with 46% APOE e4 positivity, more than twice the rate of 22% among persons without PH. Subclinical or worse cognitive decline relative to internal normative data has been observed in 17.6% of the cohort. Twenty-eight percent exhibit amyloid and/or tau positivity. Biomarker elevations, but not APOE or PH status, are associated with cognitive decline. Salutary health and lifestyle factors are associated with better cognition and brain structure, and lower AD pathophysiologic burden. Of paramount importance is establishing the amyloid and tau AD endophenotypes to which cognitive outcomes can be linked. Such data will provide new knowledge on the early temporal course of AD pathophysiology and inform the design of secondary prevention clinical trials.

show abstract

Occupational Complexity and Cognitive Reserve in a Middle-Aged Cohort at Risk for Alzheimer's Disease

Cited by 111 publications

References 35 publications

Cognitive reserve as an outcome predictor: first‐episode affective versus non‐affective psychosis

Cognitive reserve as an outcome predictor: first‐episode affective versus non‐affective psychosis

BDNF Val66Met predicts cognitive decline in the Wisconsin Registry for Alzheimer's Prevention

The Wisconsin Registry for Alzheimer’s Prevention: A Review of findings and current directions

Contact Info

Product

Resources

About