Occupational asthma to “the miracle tree” (Moringa oleifera): first description

Poussel, Mathias; Penven, Emmanuelle; Richard, Christelle; Jacquenet, S.; Chabot, F.; Paris, Christophe

doi:10.1016/j.jaip.2015.05.016

Cited by 15 publications

(6 citation statements)

References 6 publications

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“…Chronic types classification when Moringa used for six months or up to years [9]. Chronic types side effect classification in case reports of Poussel et al [10] and Olanrewaju et al [11] due to Moringa is consumed for a long time, about 1-2 years. The case reports of Berglund [12] The presence of side effect reactions due to the use of Moringa leaves or seeds can be seen from the physical examination results and the results of the patient's laboratory tests presented in Table 2.…”

Section: Resultsmentioning

confidence: 99%

Systematic Literature Review: Side Effect of Moringa oleifera Lam.

Wijaya,

Krisnawan,

Yunita

et al. 2023

Advances in Biological Sciences Research

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Moringa oleifera Lam. (Drumstick tree) is a herbal plant commonly found in subtropical and tropical areas such as Indonesia. Moringa plants have been widely used because they have many pharmacological effects. In addition, due to the high consumption of Moringa, there still needs to be monitoring regarding the safety of Moringa. This study aimed to Identify and analyze the side effects of using Moringa based on the results of a systematic literature review. A systematic literature review using articles with a case report study design (collected from 2011 to 2021). The search databases used are PubMed, Google Scholar, and Science Direct. Journal quality is assessed by JBI (Joanna Briggs Institute) Critical Appraisal. 10 articles met the criteria and were of good quality. Based on the results, the side effects that occur in the use of Moringa are in the respiratory tract, dermal, and rhabdomyolysis. The incidence of side effects in Moringa is associated with chemical compounds contained in Moringa which can trigger hypersensitivity reactions and structural similarities to other synthetic drug compounds so that they can cause the same side effect reactions. Moringa in both leaves and seeds can cause side effects, the manifestations of which are respiratory, dermal, and rhabdomyolysis disorders.

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Section: Resultsmentioning

confidence: 99%

Systematic Literature Review: Side Effect of Moringa oleifera Lam.

Wijaya,

Krisnawan,

Yunita

et al. 2023

Advances in Biological Sciences Research

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“…There have been a few cases of allergic reaction to M. oleifera in the literature: a FFE with positive rechallenge, 3 a Stevens–Johnson syndrome without skin tests performed but which experienced two flare‐ups, 4 a case of anaphylaxis after consuming the leaves with a positive prick test 5 and a case of occupational asthma 6 . In our case, the positive self‐challenge confirmed the diagnosis of M. oleifera FFE, despite the negative in situ patch‐test.…”

Section: Discussionmentioning

confidence: 99%

Fixed food eruption to Moringa oleifera

et al. 2023

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“…It is important to note that some individuals may be allergic to the consumption of M. oleifera leaves. A case of occupational asthma due to M. oleifera seed powder in the workplace of a worker in a cosmetics manufacturer has been reported [ 5 ]. There have been several studies on M. oleifera leaf allergens.…”

Section: Introductionmentioning

confidence: 99%

The Potential Role of Moringa oleifera Lam. Leaf Proteins in Moringa Allergy by Functionally Activating Murine Bone Marrow-Derived Dendritic Cells and Inducing Their Differentiation toward a Th2-Polarizing Phenotype

Xi,

Li,

Liu

et al. 2023

Nutrients

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Moringa oleifera leaves are an inexpensive substitute for staple foods. Despite limited data, Moringa oleifera leaf protein (Mo-Pr) may be allergenic in BALB/c mice. In mouse models and allergic patients, dendritic cells (DCs) may be involved in food allergy. In addition, some allergens, including food allergens, can directly activate DCs and induce Th2 polarization. We investigated whether Mo-Pr can modulate the functional profile of murine bone marrow-derived dendritic cells (BMDCs) in vitro. BMDCs were obtained from mouse bone marrow cultured with granulocyte–macrophage colony-stimulating factor (GM-CSF) for 7 days and then treated with lipopolysaccharide (LPS) or Mo-Pr. BMDC phenotypes were evaluated via flow cytometry, cytokine production was assessed using ELISA, the expression of key genes was studied using qRT-PCR, the effects on T-cell differentiation were investigated using mixed lymphocyte reaction (MLR), and transcriptional changes in BMDCs were investigated using RNA-Seq. Mo-Pr-specific IgE was investigated in recipient serum after BMDC transfer. Mo-Pr treatment significantly induced BMDC maturation, increased the expression of CD80/86 and MHC II, resulted in the production of IL-12 and TNF-α, and induced T-cell differentiation. Mo-Pr treatment stimulated BMDCs’ expression of the Th2 promoters OX40L and TIM-4, induced the production of the Th2-type chemokines CCL22 and CCL17, and decreased the Th1/Th2 ratio in vitro. Healthy recipients of Mo-Pr-treated BMDCs produced Mo-Pr-specific IgE.

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Occupational asthma to “the miracle tree” (Moringa oleifera): first description

Cited by 15 publications

References 6 publications

Systematic Literature Review: Side Effect of Moringa oleifera Lam.

Systematic Literature Review: Side Effect of Moringa oleifera Lam.

Fixed food eruption to Moringa oleifera

The Potential Role of Moringa oleifera Lam. Leaf Proteins in Moringa Allergy by Functionally Activating Murine Bone Marrow-Derived Dendritic Cells and Inducing Their Differentiation toward a Th2-Polarizing Phenotype

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