Occupational asthma

Malo, Jean‐Luc

doi:10.1016/b978-0-7234-3691-1.00062-3

Cited by 4 publications

(4 citation statements)

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“…The methacholine concentration required for a 200% increase in P enh from the post-saline value (PC 200 ), the maximal response to methacholine (Maximal P enh ), and the slope of the methacholine dose-response curve (by linear regression) (DRS) were calculated as indices of airway sensitivity, excessive airway narrowing, and airway reactivity, respectively. As a three-fold improvement in PC 20 is considered significant in occupational asthma, 22 the fold increase in PC 200 (i.e., ratio of second PC 200 value to first PC 200 value) was calculated to evaluate the degree of improvement after treatment.…”

Section: Methodsmentioning

confidence: 99%

Therapeutic Effects of Mycobacterial Secretory Proteins Against Established Asthma in BALB/c Mice

Han

Choi

et al. 2012

Allergy Asthma Immunol Res

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Purpose Live/killed mycobacteria and culture supernatants can suppress asthmatic reactions. This study investigated whether mycobacterial secretory proteins have therapeutic effects on asthma. Methods Mycobacterium bovis bacille Calmette-Guérin (BCG; 2×10 5 CFUs) and mycobacterial secretory proteins (Ag85 complex, 38-kDa protein or MPB70; 4 or 20 µg) were administered intraperitoneally to female BALB/c mice with established airway hyperresponsiveness. One week after treatment, the mice underwent a methacholine challenge test, and then inflammatory cell numbers in bronchoalveolar lavage fluid (BAL) and around bronchi (<500 µm), and cytokine levels in splenocyte supernatants, were assessed. Results BCG and all of the tested secretory proteins significantly improved airway sensitivity compared to baseline values ( P <0.05). The secretory protein Ag85 complex significantly suppressed airway reactivity also ( P <0.05), while 38-kDa protein significantly suppressed reactivity and maximal narrowing ( P <0.05). The number of eosinophils in BAL and around bronchi, and the goblet cell proportion, were also significantly reduced in mice in both the BCG and secretory protein groups compared to the asthma control group. IFN-γ/IL-5 ratios were significantly higher in mice treated with BCG, 4 µg MPB70 or 4 µg 38-kDa protein than in asthma control mice ( P <0.05), and were negatively associated with airway hyperresponsiveness, peribronchial eosinophil numbers and goblet cell proportion (all P <0.05). IL-17A was positively correlated with IL-5 (r=0.379, P <0.001), maximal airway narrowing, peribronchial eosinophil numbers and goblet cell proportion (all P <0.05). Conclusions Secretory proteins from BCG and M. tuberculosis and live BCG were effective against established asthma, their effects being accompanied by increased IFN-γ/IL-5 ratios. Thus, allergic asthma could be effectively treated with mycobacterial secretory proteins.

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Section: Methodsmentioning

confidence: 99%

Therapeutic Effects of Mycobacterial Secretory Proteins Against Established Asthma in BALB/c Mice

Han

Choi

et al. 2012

Allergy Asthma Immunol Res

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“…Asthma is a chronic inflammatory disorder of the airways. Occupational asthma (OA) is asthma that is caused and maintained by conditions attributable to the occupational environment and not to stimuli encountered outside the workplace [ 1 ]. The impact of a disease on a patient's health and well-being is individual.…”

Section: Introductionmentioning

confidence: 99%

Identification of clinically significant psychological distress and psychiatric morbidity by examining quality of life in subjects with occupational asthma

Malka

Lavoie

L’Archevêque

et al. 2011

Health Qual Life Outcomes

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BackgroundThe Juniper Asthma Specific Quality of Life Questionnaire (AQLQ(S)) is a questionnaire that allows measurement of disease specific quality of life. We wanted to examine correlations between the (AQLQ(S)) general and different subscale scores and both psychiatric morbidity and levels of psychological distress in individuals with occupational asthma (OA) and to determine if results in the emotional function subscale allow identification of individuals with clinically significant psychological distress or current psychiatric disorders.MethodsThis was a cross-sectional study of individuals with OA who were assessed during a re-evaluation for permanent disability, after they were no longer exposed to the sensitizing agent. Patients underwent a general sociodemographic and medical history evaluation, a brief psychiatric interview (Primary Care Evaluation of Mental Disorders, PRIME-MD) and completed a battery of questionnaires including the AQLQ(S), the St-Georges Respiratory Questionnaire (SGRQ), and the Psychiatric Symptom Index (PSI).ResultsThere was good internal consistency (Cronbach alpha = 0.936 for the AQLQ(S) total score) and construct validity for the AQLQ(S) (Spearman rho = -0.693 for the SGRQ symptom score and rho = -0.650 for the asthma severity score). There were medium to large correlations between the total score of the AQLQ(S) and the SGRQ symptom score (r = -.693), and PSI total (r = -.619) and subscale scores (including depression, r = -.419; anxiety, r = -.664; anger, r = -.367; cognitive disturbances, r = -.419). A cut-off of 5.1 on the AQLQ(S) emotional function subscale (where 0 = high impairment and 7 = no impairment) had the best discriminative value to distinguish individuals with or without clinically significant psychiatric distress according to the PSI, and a cut-off of 4.7 best distinguished individuals with or without a current psychiatric disorder according to the PRIME-MD.ConclusionsImpaired quality of life is associated with psychological distress and psychiatric disorders in individuals with OA. Findings suggest that the AQLQ(S) questionnaire may be used to identify patients with potentially clinically significant levels of psychological distress.

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“…Sensitiser‐induced OA is characterized by development of asthma after a latency period ranging between days and years after initial occupational exposure. HMW agents (>10 kDa) act as antigens and induce production of antigen‐specific IgE 8 . Although some LMW agents also induce specific IgE by acting as haptens, most LMW chemicals induce asthma via cellular immune‐mediated pathways.…”

Section: Definitionsmentioning

confidence: 99%

Work‐related asthma: A position paper from the Thoracic Society of Australia and New Zealand and the National Asthma Council Australia

et al. 2020

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Work-related asthma (WRA) is one of the most common occupational respiratory conditions, and includes asthma specifically caused by occupational exposures (OA) and asthma that is worsened by conditions at work (WEA). WRA should be considered in all adults with asthma, but especially those with new-onset or difficult to control asthma. Improvement in asthma symptoms when away from work is suggestive of WRA. Clinical history alone is insufficient to diagnose WRA; therefore, objective investigations are required to confirm the presence of asthma and the association of asthma with work activities. Management of WRA requires pharmacotherapy similar to that of non-WRA, however, also needs to take into account control of the causative workplace exposure. Ongoing exposure will likely lead to decline in lung function and worsening asthma control. WRA is a preventable condition but this does rely on increased awareness of WRA and thorough identification and control of all potential occupational respiratory hazards.

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Occupational asthma

Cited by 4 publications

References 46 publications

Therapeutic Effects of Mycobacterial Secretory Proteins Against Established Asthma in BALB/c Mice

Therapeutic Effects of Mycobacterial Secretory Proteins Against Established Asthma in BALB/c Mice

Identification of clinically significant psychological distress and psychiatric morbidity by examining quality of life in subjects with occupational asthma

Work‐related asthma: A position paper from the Thoracic Society of Australia and New Zealand and the National Asthma Council Australia

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