Occupational and non‐occupational allergic contact dermatitis from beryllium

Vilaplana, J.; Romaguera, C.; Grimalt, F.

doi:10.1111/j.1600-0536.1992.tb00121.x

Cited by 26 publications

(17 citation statements)

References 9 publications

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“…Dental alloys are subjected to a wide variety of corrosive media, often acidic, and this combined with concomitant abrasion increases the probability of breakdown of protective, oxide, surface films and the likelihood of formation of soluble beryllium and nickel ions. Contact dermatitis from Ni-Cr-Be dental alloys has been reported (22) and (23) and, in the latter case, specifically ascribed to beryllium.…”

Section: Berylliummentioning

confidence: 99%

A metallurgical approach to metal contact dermatitis

Flint¹

1998

Contact Dermatitis

129

105

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It is well-known that some metals/alloys are sensitizing on skin contact, but it is not so well appreciated that sensitization is dependent on the reaction of the metal/alloy with sweat. The first step in skin sensitization by metals/alloys is a corrosion process and the formation of soluble metal ions. The nature of this process has implications with respect to occurrence of metal contact dermatitis, to testing techniques and to classification of metals/alloys as skin sensitizers.

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Section: Berylliummentioning

confidence: 99%

A metallurgical approach to metal contact dermatitis

Flint¹

1998

Contact Dermatitis

129

105

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“…77 Chronic gingivitis has been reported adjacent to beryllium-containing dental crowns and bridges suggesting that this response may be apparent with beryllium metal and salts. 108,109 Chronic, nonhealing ulcers are reported with implantation of beryllium into an abrasion or other cut in the skin 77 and excision is required for resolution. 110 Nodular granulomatous skin lesions with appearance similar to warts may develop with and without known penetration of beryllium into the skin, and have been treated with excision 79 or use of steroids.…”

Section: Skin Manifestationsmentioning

confidence: 99%

Sarcoidosis and Chronic Beryllium Disease: Similarities and Differences

Mayer

Hamzeh

Maier

2014

Semin Respir Crit Care Med

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Chronic beryllium disease (CBD) is a granulomatous lung disease that may be pathologically and clinically indistinguishable from pulmonary sarcoidosis, except through use of immunologic testing, such as the beryllium lymphocyte proliferation test (BeLPT). Similar to sarcoidosis, the pulmonary manifestations of CBD are variable and overlap with other respiratory diseases. Definitive diagnosis of CBD is established by evidence of immune sensitization to beryllium and diagnostic bronchoscopy with bronchoalveolar lavage and transbronchial biopsy. However, the diagnosis of CBD can also be established on a medically probable basis in beryllium-exposed patients with consistent radiographic imaging and clinical course. Beryllium workers exposed too much higher levels of beryllium in the past demonstrated a much more fulminant disease than is usually seen today. Some extrapulmonary manifestations similar to sarcoidosis were noted in these historic cohorts, although with a narrower spectrum. Extrapulmonary manifestations of CBD are rare today. Since lung-predominant sarcoidosis can very closely resemble CBD, CBD is still misdiagnosed as sarcoidosis when current or past exposure to beryllium is not recognized and no BeLPT is obtained. This article describes the similarities and differences between CBD and sarcoidosis, including clinical and diagnostic features that can help physicians consider CBD in patients with apparent lung-predominant sarcoidosis.

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“…In frühen Krankheitsphasen kann sich der physikalische Befund auf ein Knisterrasseln beschränken, Lungenfunktion und Tho− raxröntgenbild sind normal, und nur die HRCT zeigt richtungs− weisende Veränderungen [15,69]. [13,65], England [78], Schweden [79], Israel [80], Deutschland [81,82] [16]. Weitere Differenzialdiagnosen, die bei der Abklärung eines granulomatösen Krankheitsbildes be− dacht werden müssen, finden sich in l " Tab.…”

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Chronische Berylliose

Müller–Quernheim¹,

Gaede²,

Prasse³

et al. 2007

Pneumologie

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Chronic Berylliosis (CB) is an occupational disorder which needs to be considered in the diagnostic work-up of granulomatous pulmonary diseases. Germany imports increasing amounts of beryllium which causes increased occupational exposure and this fact suggests that CB is underdiagnosed. Since CB is a perfect phenocopy of sarcoidosis, it is assumed that many cases are hidden in the cohort of sarcoidosis patients. This review presents the epidemiology, pathogenesis, diagnostics, and therapy of CB.

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Occupational and non‐occupational allergic contact dermatitis from beryllium

Cited by 26 publications

References 9 publications

A metallurgical approach to metal contact dermatitis

A metallurgical approach to metal contact dermatitis

Sarcoidosis and Chronic Beryllium Disease: Similarities and Differences

Chronische Berylliose

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