Occupational and life-style factors-acquired mutagenicity in agric-workers of northeastern Brazil

Chaves, Tatiana Vieira Souza; Islam, Muhammad Torequl; Moraes, Manoel Odoríco de; Alencar, Marcus Viní­cius Oliveira Barros de; Gomes, Débora Cássia Vieira; Carvalho, Rodrigo Mendes de; Maluf, Sharbel Weidner; Amaral, Fabrício Pires de Moura do; Paz, Márcia Fernanda Correia Jardim; Cerqueira, Gilberto Santos; Rolim, Hercí­lia Maria Lins; Sousa, João Marcelo de Castro e; Melo‐Cavalcante, Ana Amélia de Carvalho; Moraes, Maria Elisabete Amaral de

doi:10.1007/s11356-017-9150-y

Cited by 19 publications

(5 citation statements)

References 32 publications

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“…Data obtained through manovacuometry in the studied groups presented lower values when compared to the literature 12 , 24 ; this was expected since Simões et al 25 noted that a physiological loss of strength by respiratory muscles occurs with age, being more evidenced from the fourth decade of life. The measured values in the studied population were thus expected to be altered: their decrease was enhanced due to pesticide exposure.…”

Section: Discussionmentioning

confidence: 50%

Assessment of the respiratory function of farmers exposed to pesticides in the municipality of Quilombo (state of Santa Catarina, Brazil): relationship between health and occupational protection

et al. 2021

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Introduction Rural workers are exposed to various occupational risks, especially considering the exposure to pesticides. This exposure can lead to respiratory intoxications being the most frequent complaint by these professionals, which could be associated to the lack or improper use of personal protective equipment. Objectives To assess the respiratory function of rural workers exposed to pesticides in the municipality of Quilombo, state of Santa Catarina, Brazil. Methods This study was quantitative, observational, and descriptive. Our sample consisted of 31 rural workers aged between 25 and 45 years and divided into 2 age groups; we aimed to assess the effect of the period of exposure to pesticides. The participants answered a questionnaire, followed by a respiratory function assessment including measurements of inspiratory and expiratory muscle strength using a manovacuometer, of peak expiratory flow with a peak flow meter, and of tidal volume with a ventilometer. Results The groups presented decreases in respiratory muscle strength, peak expiratory flow, and tidal volume. Conclusions The damage to expiratory function observed in the evaluated sample presents, as a main factor, the lack of personal protective equipment use; therefore, education and health strategies are needed to instrumentalize these workers and reduce the development of occupational risks.

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Section: Discussionmentioning

confidence: 50%

Assessment of the respiratory function of farmers exposed to pesticides in the municipality of Quilombo (state of Santa Catarina, Brazil): relationship between health and occupational protection

et al. 2021

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“…Smoking has been related with MN induction and buccal cell lesions [47][48][49] , while alcohol drinking has not been associated with increased MN frequencies 50) although there are reports indicating a minor association 51,52) . However an association was observed when additional parameters were considered together with alcohol drinking 53,54) . Thus the consideration of confounding factors has to be taken seriously when one attempts to study the involvement of the working environment on workers' health.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the genetic damage to workers in a Greek shipyard

et al. 2021

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Shipyards are industrial areas where workers are likely exposed to environmental pollutants such as welding fumes, fine organic solvent and dye dust, that render the occupational environment a high risk one. Assessing the risk that workers are exposed to is a high critical factor in improving their working conditions. The present study aims to investigate the potential genetic damage to workers exposed to a harsh environment in a Greek shipyard. It is focused on assessing the percentage of induced GENETIC DAMAGE TO SHIPYARD WORKERS micronuclei, as well as on changes in the various cell types of shipyard workers' oral mucosa epithelium by implementing the buccal micronucleus cytome assay. Exposed workers appeared with statistically significant induced micronuclei as compared to office employees. Statistically, significant cell lesions were detected and are related to workers' exposure to environmental conditions. The workers' smoking habit contributed as well to the observed buccal epithelial cell alterations. The observed data signify the high-risk workers are exposed; resulting in the shipyard's management the need to implement measures improving the working environment conditions and to reevaluate the workers' personal protective equipment requirements.

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“…Researches on pesticide-exposed workers from all over the world in the last decade also demonstrated statistically signifi cant DNA damage, MN and CAs [17][18][19][20][21][22][23][24][25][26][27][28][29][30]. In a recent study, it was found an increased frequency of MN and CAs in pesticide-exposed agricultural workers from northeastern Brazil [25]. By the other hand, other studies have indicated that pesticide exposure caused no signifi cant genotoxic effect in agricultural workers, when compared to the control population [31,32].…”

Section: Discussionmentioning

confidence: 99%

Chromosomal Aberrations in agricultural farmers exposed to pesticides

Demırhan¹,

Akbaba²,

Çelik³

et al. 2019

Adv Toxicol Toxic Effects

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Pesticides which constitute an group of environmental pollutants are commonly used in agriculture to protect crops. Pesticide exposure may be associated with increased risk of genotoxicity and carcinogenesis. Therefore, they pose a potential risk to farmers and environment. The aim of the present study is to investigate whether occupational exposure to various pesticides causes Chromosomal Aberrations (CAs) in agricultural farmers. The frequency of CAs in peripheral blood lymphocytes were evaluated in 35 Agricultural Farmers (AFs) and 40 control subjects living in Çukurova Region. The results showed that farmers exposed to pesticides had signifi cantly increased frequencies of CAs when compared with controls (P<0.05). Ageadjusted group comparisons showed that the frequency of CAs in the pesticide exposed AFs were 2,3 times higher than in the control group (OR: 2,3, 95% wald confi dence limits: 1,9-2,9). The confounding factors such as variable duration of pesticide exposure, age, smoking, alcohol consumption had no signifi cant effect on cytogenetic damage (P>0.05). Fragile sites (FSs) on the 1(q21-24), 1(q31-32), 2(q31-34), 2(q21-23), 3(p21), 3(p25) and 5(q31-q34) chromosomal regions were signifi cantly overexpressed in AFs, when compared to the control group (in 12.6% versus 4.3% of cells) (P<0.05). Our fi ndings indicate that occupational exposure to pesticides could cause cytogenetic damage in somatic cells of AFs. It is known that accumulation of CAs is a crucial step for initiation of many cancers. Therefore, it is suggested that the exposed workers should be warned about the potential harmful effects of pesticides and relevant authorities should safeguard that protective measures are taken by farmers while working in agricultural fi elds.

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Occupational and life-style factors-acquired mutagenicity in agric-workers of northeastern Brazil

Cited by 19 publications

References 32 publications

Assessment of the respiratory function of farmers exposed to pesticides in the municipality of Quilombo (state of Santa Catarina, Brazil): relationship between health and occupational protection

Assessment of the respiratory function of farmers exposed to pesticides in the municipality of Quilombo (state of Santa Catarina, Brazil): relationship between health and occupational protection

Evaluation of the genetic damage to workers in a Greek shipyard

Chromosomal Aberrations in agricultural farmers exposed to pesticides

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