Occupational and environmental exposure to lead and reproductive health impairment: An overview

Kumar, Sunil

doi:10.4103/ijoem.ijoem_126_18

Cited by 76 publications

(11 citation statements)

References 50 publications

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“…Pregnant women should be advised to avoid occupational or environmental settings with a high risk of lead exposure. Education on lead-safe practices, including proper hygiene, nutrition, and home maintenance, can also help minimize exposure [35] , [36] . In cases where pregnant women are found to have elevated blood lead levels, close monitoring of their clinical outcomes is crucial.…”

Section: Discussionmentioning

confidence: 99%

DNA damage and ALAD polymorphism in high blood lead (Pb) levels of pregnant women attending a tertiary care teaching hospital

Sahu,

Upadhyay,

Gupta

et al. 2024

European Journal of Obstetrics & Gynecology and Reproductiv

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Section: Discussionmentioning

confidence: 99%

DNA damage and ALAD polymorphism in high blood lead (Pb) levels of pregnant women attending a tertiary care teaching hospital

Sahu,

Upadhyay,

Gupta

et al. 2024

European Journal of Obstetrics & Gynecology and Reproductiv

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“…The lack of high-quality healthcare coverage and low education levels leads to a very scarce use of personal protection elements, and an increase in the potential risk of exposure to contaminants such as toxic metals, making the effects of occupational exposure an important factor in the burden of disease and the years lost due to disability [20]. Pb and Cd are still highly important elements for the development of the economy.…”

Section: Discussionmentioning

confidence: 99%

“…Evidence points out that exposure to Pb causes changes in DNA methylation, causing alterations in DNA methyltransferases, increased concentration of oxidative stress, alterations in the endocrine system, metabolic syndrome, increased blood pressure, increased risk of cancer, neurotoxic effects, cognitive dysfunction in child and adults [3,5,[15][16][17], renal dysfunction [16], cardiovascular disease [18], hypertension [19], and reproductive organ dysfunction in males and females [20]. Due to the well-known toxicity of Pb in public health, a BLL of concern or blood lead reference value (BLRV) has been lowered from 60 to 3.5 µg/dL between 1960 and 2021.…”

Section: Introductionmentioning

confidence: 99%

Biochemical and Hematological Markers in Workers with Chronical Exposure to Lead and Cadmium in Colombia

Vergara-Murillo

Martinez-Yanez

Fortich-Revollo

et al. 2022

Toxics

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The aim of the present study was to find if workers chronically exposed to lead (Pb) and cadmium (Cd) presented changes in their general health and in the clinical parameters of the population under study. We carried out a cross-sectional survey in a sample of informal workers in Cartagena, Colombia. The population under study was composed of male informal workers (≥18 years of age), with experience in their job, selected from occupational settings with potential exposure to Pb and Cd (i.e., mechanics, battery and garbage recyclers, and welders). The median age was 45 years (interquartile range (IQR), 33–53). The median blood Pb level (BLL) was 2 μg/dL (IQR, 0.76–6.22), and the median of blood Cd level (BCL) was 1.22 μg/L (IQR, 0.33–2.01). The study found that 33% of high exposure jobs with BLL > 5 μg/dL (n = 57), whereas in ‘control’ workers, this was 15.3% (n = 9). The highest BLLs were found in battery recyclers (82.1%; n = 23), followed by mechanics (37.3%, n = 22). In the logistic regression model adjusted by age, time on the job, smoking and elevated BCL and BLL increased 3.2 times (95% CI, 1.1–9.7) in mechanics and 29.6 times (95% CI, 7.2–145.6) in battery recyclers. This study found negative changes in the health of workers with higher chronic exposure to lead in Cartagena, Colombia.

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“…In India, apart from various occupations in the unorganized sector, possible exposure to lead may occur in the cosmetic and traditional medicine-related industries [ 84 ]. The adverse and toxic effect of lead on the human reproductive system has already been reported [ 85 ]. Apart from occupational aspects, lead exposure may occur in a normal household through paints and children's polyvinyl chloride (PVC) toys [ 86 ].…”

Section: Reviewmentioning

confidence: 99%

Environmental Exposure: Effect on Maternal Morbidity and Mortality and Neonatal Health

Kumārī¹,

Sharma²,

Keshari³

et al. 2023

Cureus

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Environmental factors are important causes that impair global pregnancy outcomes and are, importantly, responsible for maternal morbidity and mortality. However, apart from the direct reasons for maternal deaths, mainly obstetric and neonatal complications, such factors are ignored or given less importance. The recent surge in research on the impact of various environmental factors on pregnancy outcomes suggests the need for immediate attention to such factors and device-specific policies to counter the situation. Moreover, the recent coronavirus disease of 2019 (COVID-19) pandemic, global warming, and climate change showed a lack of preparedness to counter the impact of such events on maternal survival and safe and successful pregnancy outcomes. In the present review, we have emphasized the specific factors responsible for increased maternal and neonatal deaths and their association with specific environmental factors. Increased attention on maternal healthcare, preparedness to counter sudden environmental challenges and improvement of the conventional requirement for better maternal healthcare access and nutrition at a global level may improve the scenario.

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Occupational and environmental exposure to lead and reproductive health impairment: An overview

Cited by 76 publications

References 50 publications

DNA damage and ALAD polymorphism in high blood lead (Pb) levels of pregnant women attending a tertiary care teaching hospital

DNA damage and ALAD polymorphism in high blood lead (Pb) levels of pregnant women attending a tertiary care teaching hospital

Biochemical and Hematological Markers in Workers with Chronical Exposure to Lead and Cadmium in Colombia

Environmental Exposure: Effect on Maternal Morbidity and Mortality and Neonatal Health

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