Occupational and Environmental Allergic Problems of the Skin*

Suskind, Raymond R.; Majeti, Vimala

doi:10.1111/j.1346-8138.1976.tb00963.x

Cited by 16 publications

(5 citation statements)

References 18 publications

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“…Cinnamaldehyde can be viewed as a derivative of acrolein or crotonaldehyde, for which the mechanism of reaction with proteins has been completely elucidated. , However, it is uncertain which proteins or other macromolecules react with cinnamaldehyde and among those that do, which groups have the greatest potential to react . Majeti and Suskind found that cinnamaldehyde reacts with amino groups on protein side chains, giving rise to the corresponding Schiff base derivatives. , Weibel and Hansen claimed that thiol groups in cysteine residues were the most common binding sites on bovine serum albumin . Dupuis and Benezra suggested that a conjugate is formed by a Michael addition (1,4-addition) of cinnamaldehyde to the free amino groups in lysine residues .…”

Section: Introductionmentioning

confidence: 99%

“…26 Majeti and Suskind found that cinnamaldehyde reacts with amino groups on protein side chains, giving rise to the corresponding Schiff base derivatives. 27,28 Weibel and Hansen claimed that thiol groups in cysteine residues were the most common binding sites on bovine serum albumin. 26 suggested that a conjugate is formed by a Michael addition (1,4-addition) of cinnamaldehyde to the free amino groups in lysine residues.…”

Section: ' Introductionmentioning

confidence: 99%

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Biochemical Properties of Bioplastics Made from Wheat Gliadins Cross-Linked with Cinnamaldehyde

Balaguer

Gómez-Estaca

Gavara

et al. 2011

J. Agric. Food Chem.

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The aim of this work has been to study the modification of gliadin films with cinnamaldehyde as a potential cross-linker agent. The molecular weight profile and cross-linking density showed that cinnamaldehyde increased reticulation in the resulting films. The participation of free amino groups of the protein in the newly created entanglements could be a possible mechanism of connection between the polypeptidic chains. The combination of a Schiff base and a Michael addition is a feasible approach to understanding this mechanism. The protein solubility in different media pointed to lower participation by both noncovalent and disulfide bonds in stabilizing the structure of the cross-linked films. The new covalent bonds formed by the cinnamaldehyde treatment hampered water absorption and weight loss, leading to more water-resistant matrices which had not disintegrated after 5 months. The properties of this novel bioplastic could be modified to suit the intended application by using cinnamaldehyde, a naturally occurring compound.

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Section: Introductionmentioning

confidence: 99%

Section: ' Introductionmentioning

confidence: 99%

Biochemical Properties of Bioplastics Made from Wheat Gliadins Cross-Linked with Cinnamaldehyde

Balaguer

Gómez-Estaca

Gavara

et al. 2011

J. Agric. Food Chem.

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“…Some speculations on the mechanism of cinnamic aldehyde sensitization and quenching effects have been made regarding its molecular structure (9,10,11), but conclusive explanation has never been established.…”

Section: Discussionmentioning

confidence: 99%

Studies on the cutaneous sensitization reaction of guinea pigs to purified aromatic chemicals

Senma¹,

Fujiwara²,

Sasaki³

et al. 1978

Acta Derm Venereol

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The sensitization reactions to purified cinnamic aldehyde and its chemically related substances were investigated using the maximization test on guinea pigs. Mutual cross-sensitivities were also examined. Cinnamic aldehyde was found to be the most potent sensitizer in this series, and a strong cross-sensitizer. From the chemical structures of these substances, the following speculations were made. There was a tendency that as the number of hydrocarbons of alkyl groups replacing the alpha-hydrogen in the molecule increased, the rate of sensitization reaction declined. The conjugated system of double bonds was suspected to be a determinant factor in relation to the sensitization ability of the substances in this series.

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“…The most common pathological response as with most tissues is that of inflammation (13)(14)(15)(16)(17)(18)(19)(20)(21)(22). It is the characteristic response to a primary irritant and to antigen-induced cell-mediated hypersensitivity reactions.…”

Section: Inflammatory Reactionsmentioning

confidence: 99%

Environment and the skin

Suskind¹

1977

Environ Health Perspect

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The skin is an important interface between man and his environment; it is an important portal of entry for hazardous agents and a vulnerable target tissue as well. It is a uniquely accessible model system for detecting hazards and for studying mechanisms of a wide variety of biologic funcitons. Environmental causes of skin reactions comprise a vast array of physical, chemical and biological agents. To appreciate the role of the skin as an interface with man's environment, it is necessary to understand the multiple adaptive mechanisms, and the defenses of the skin against the environmental stresses. The skin is endowed with a versatile group of defenses against penetration, fluid loss from the body, thermal stress, solar radiation, physical trauma and microbial agents. Patterns of adverse response range in quality and intensity from uncomplicated itching to metastatic neoplasia. Environmental problems comprise a large segment of disabling skin disease. Although critical epidemiologic data is limited, cutaneous illnesses comprise a significant segment of occupational disease. This represents a significant loss in productivity and a major cause of disability. The most serious research needs include the development of surveillance systems for identifying skin hazards and determining frequency of environmental skin disease; the development of new models for studying cutaneous penetration; the elucidation of the mechanisms of nonallergic inflammatory reactions (primary irritation) and of the accommodation phenomenon; the development of more sensitive models for predicting adverse responses to marginal irritants; the utilization of modern skills of immunobiology and immunochemistry to elucidate mechanisms of allergic responses; the launching of epidemiologic studies to determine the long term effects of PCBs and associated compounds such as dioxins; and the expansion of research in the mechanisms of skin cancer in relation to susceptibility, genetic and metabolic considerations, ultraviolet light, and phototoxic agents.

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Occupational and Environmental Allergic Problems of the Skin*

Cited by 16 publications

References 18 publications

Biochemical Properties of Bioplastics Made from Wheat Gliadins Cross-Linked with Cinnamaldehyde

Biochemical Properties of Bioplastics Made from Wheat Gliadins Cross-Linked with Cinnamaldehyde

Studies on the cutaneous sensitization reaction of guinea pigs to purified aromatic chemicals

Environment and the skin

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