Occupational allergy to locusts: An investigation of the sources of the allergen

Tee, R D; Gordon, Debbie; Hawkins, Edward; Nunn, AJ; Lacey, J.; Venables, K M; Cooter, R. J.; McCaffery, Alan R.; Taylor, A J Newman

doi:10.1016/0091-6749(88)90188-1

Cited by 56 publications

(40 citation statements)

References 9 publications

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“…Allergy: Periplaneta americana (whole body, haemolymph and faecal matter), Blatella germanica and Supella longipalpa (Blattodea) Symptoms: Nasal stuffiness, runny nose, sneezing, ocular itching, and palatal itching Monk (1988) 1980s UK Laboratory insectary: Biochemist working with locusts (Orthoptera) Allergy: locusts (Orthoptera) Symptoms: Itching, redness, swelling, asthma, urticaria, and conjunctivitis Schroeckenstein et al (1988 USA Laboratory insectary: research entomologist working with many insects, including Alphitobius diaperinus (Coleoptera) Allergy: Alphitobuys diaperinus (larvae, pupae and adults) (Coleoptera) Symptoms: rhinitis, pruritus, angioedema, asthma, tongue swelling, difficulty talking, urticaria, and conjunctivitis Tee et al (1988) 1980s UK Research centre: working with locusts (Orthoptera) Allergy: Locusta migratoria and Schistocerca gregaria (Orthoptera) Symptoms: Bronchial asthma, urticaria, and rhinitis Kaufman et al (1989) 1980s Australia Research centre: working with Lucilia cuprina (Diptera) Allergy: Lucilia cuprina (larva and adults) (Diptera) Symptoms: Rhinitis, rashes, asthma, chest tightness, conjunctivitis, 'pleuritic' type pain, nasal obstruction, nasal itching, rhinorrhoea, sneezing, itching pharynx, nasal dryness, dry pharynx, nasal soreness, nasal crusting, ocular itching, ocular pain, ocular erythema, ocular oedema, lachrimation, urticaria, and pruritus Nakazawa and Umegae (1990) 1980s Japan Sericulturist rearing Bombyx mori (Lepidoptera) Allergy: Bombyx mori (Lepidoptera) leading to granulomatous interstitial pneumonia secondary to hypersensitivity pneumonitis Symptoms: cough, exertional dyspnoea, fever, sputum production, and weight loss Schroeckenstein et al (1990 USA High school: Animal handler with work exposure to Tenebrio molitor (Coleoptera)…”

Section: Occupational Management Of Adverse Work-related Health Outcomesmentioning

confidence: 99%

The risky business of being an entomologist: A systematic review

Stanhope

Carver

Weinstein

2015

Environmental Research

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Section: Occupational Management Of Adverse Work-related Health Outcomesmentioning

confidence: 99%

The risky business of being an entomologist: A systematic review

Stanhope

Carver

Weinstein

2015

Environmental Research

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“…The bronchodilator effect of theophylline in chronic asthma is small in comparison with β 2 -agonists, however. Several studies have demonstrated a small protective effect of theophylline on histamine, methacholine or exercise challenge [51,52,53,54]. This protective effect does not correlate well with any bronchodilator effect and the protective effect of theophylline may be observed at plasma concentrations of <10 mg/L.…”

Section: Cellular Effectsmentioning

confidence: 99%

Theophylline

Barnes

2010

Pharmaceuticals

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Theophylline (3-methyxanthine) has been used to treat airway diseases for over 70 years. It was originally used as a bronchodilator but the relatively high doses required are associated with frequent side effects, so its use declined as inhaled β2-agonists became more widely used. More recently it has been shown to have anti-inflammatory effects in asthma and COPD at lower concentrations. The molecular mechanism of bronchodilatation is inhibition of phosphodiesterase(PDE)3 and PDE4, but the anti-inflammatory effect may be due to histone deacetylase (HDAC) activation, resulting in switching off of activated inflammatory genes. Through this mechanism theophylline also reverses corticosteroid resistance and this may be of particular value in severe asthma and COPD where HDAC2 activity is markedly reduced. Theophylline is given systemically (orally as slow-release preparations for chronic treatment and intravenously for acute exacerbations of asthma) and blood concentrations are determined mainly by hepatic metabolism, which may be increased or decreased in several diseases and by concomitant drug therapy. Theophylline is now usually used as an add-on therapy in asthma patients not well controlled on inhaled corticosteroids and in COPD patients with severe disease not controlled by bronchodilator therapy. Side effects are related to plasma concentrations and include nausea, vomiting and headaches due to PDE inhibition and at higher concentrations to cardiac arrhythmias and seizures due to adenosine A1-receptor antagonism.

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“…Die Sensibilisierung erfolgt per inhalationem und manifestiert sich als Rhinokonjunktivitis, Asthma bronchiale oder seltener perkutan mit der Folge einer Proteinkontakt urtikaria [17,18]. Berufsbedingte Sensibilisierungen gegenüber Insekten, verursacht durch Heuschrecken, Schmeißfliegen oder Kakerlaken sind wiederum v. a. bei im Labor exponierten Personen keine Seltenheit [2, 5,12,20,22]. Eine Untersuchung an Personen mit beruflichem Labortierkontakt von 1999-2000 in Groß britannien ermittelte eine Inzidenz berufsbedingter relevanter Inhalationsallergien durch die Arbeit mit Insekten im Labor für die Rhinitis mit 21/1000/Jahr und asthmatische Beschwerden mit 2,35/1000/Jahr, welche als hoch eingestuft wird [6].…”

Section: Berufsbedingte Inhalationsallergie Gegen Die Gemeine Hausfliunclassified

Berufsbedingte Inhalationsallergie gegen die gemeine Hausfliege (Musca domestica)

et al. 2007

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Isolated allergy to the common housefly (Musca domestica) has only been described in four cases. Predisposing factors include high concentrations of allergens and prolonged exposure time. Two pharmaceutical industry workers, 59 and 34 years of age, both without atopy, presented with recent onset of allergic rhinitis. Their symptoms appeared about 30 minutes after exposure to Musca domestica in the closed breeding rooms. They were symptom-free with other insects, on weekends and on vacation. Skin prick tests with common inhalant allergens were negative. Prick testing with crushed Musca domestica adults, hatched eggs, contaminated nets and sand, as well as fly feces were all positive. One patient had specific IGE antibodies against Musca domestica. Both patients lacked specific IgE antibodies against other insect species and common aeroallergens. In these two patients there was a species-specific sensitization without relevant cross reactions to other arthropods. The patients were transferred to new work sites where they had no contact with Musca domestica and became symptom-free. Thus this common insect can be a relevant occupational aeroallergen.

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Occupational allergy to locusts: An investigation of the sources of the allergen

Cited by 56 publications

References 9 publications

The risky business of being an entomologist: A systematic review

The risky business of being an entomologist: A systematic review

Theophylline

Berufsbedingte Inhalationsallergie gegen die gemeine Hausfliege (Musca domestica)

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