Occupational allergy to bumble bee venom

Kochuyt, Anne-Marie; Hoeyveld, Ernestina Van; Stevens, Erik

doi:10.1111/j.1365-2222.1993.tb00881.x

Cited by 38 publications

(26 citation statements)

References 5 publications

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“…Bumble bee stings may become more common now that bumble bee colonies are being cultivated for crop pollination. 7 Carpenter bees ( Xylocopa , in the family Anthophoridae) are large solitary bees whose nests in wood often bring them into proximity with people, whom they occasionally sting, usually when grabbed ( Fig. 1).…”

Section: Beesmentioning

confidence: 99%

Bites and stings of medically important venomous arthropods

Vetter

Visscher

1998

Int J Dermatology

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Section: Beesmentioning

confidence: 99%

Bites and stings of medically important venomous arthropods

Vetter

Visscher

1998

Int J Dermatology

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“…A high percentage of 75 and 85% of double-positive sera in honeybee- and bumblebee-allergic subjects, respectively, could indicate cross-reactivity between the two venoms [97]. Six of 7 bumblebee-allergic patients reported amelioration of their bumblebee allergy after immunotherapy with honeybee venom [98]. …”

Section: Insect Venomsmentioning

confidence: 99%

The Principle of Homologous Groups in Regulatory Affairs of Allergen Products – A Proposal

Lorenz

Lüttkopf

May

et al. 2008

Int Arch Allergy Immunol

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Among other legal regulations, the Note for Guidance on Allergen Products CPMP/BWP/243/96 released by the European Medicines Agency provides regulatory instructions regarding the quality of allergen extracts for diagnostic or therapeutic purposes. The current revision of this guideline intends to transform the so-called ‘principle of taxonomic families’ to the ‘principle of homologous groups’. According to this concept, the data of one allergen extract demonstrating stability, efficacy and safety can, to a limited extent, be extrapolated to other allergen extracts belonging to the same homologous groups. The present work proposes the formation of homologous groups for pollen species and animal-derived materials on the basis of similar biochemical composition and homology/cross-reactivity of allergens or allergen sources. Some tree pollen species could be assigned to three different homologous groups, some weed pollen species to one homologous group and numerous grass pollen species to one homologous group on condition that data rely on single defined representative species. A homologous group for mites is limited to the Dermatophagoides species and the grouping of vertebrate-derived materials such as dander could be possible under restrictions. The criteria for the formation of the proposed homologous groups are illustrated in detail to provide an opportunity for extending existing homologous groups by further species in case of new insights in allergens and cross-reactivity of allergen sources. In this way, the concept of homologous groups could serve as a dynamic tool in the regulation of allergen products.

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“…Since the presence of bumblebee venom-specific IgE has been shown in a number of patients, immunotherapy will probably be the treatment of choice. This has already been done by Kochuyt et al (2), who claim that hyposensitization of bumblebee venom-allergic patients with the readily available honeybee venom leads to positive clinical results. Although various studies on the biochemical and immunochemical characteristics of Hymenopteran venoms have been published (3)(4)(5)(6)(7)(8), reports on bumblebee venom allergens have been relatively few.…”

mentioning

confidence: 89%

Allergy to bumblebee venom. II IgE cross‐reactivity between bumblebee and honeybee venom

Stapel

Raadt

Toorenenbergen

et al. 1998

Allergy

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To obtain more information on IgE cross‐reactivity between bumblebee venom and honeybee venom, we tested sera from venom‐sensitized patients for specific IgE against venoms from the European bumblebee (Bombus terrestris), the North American bumblebee (Megabombm pennsylvanicus), and the honeybee (Apis mellifera). RAST, RAST‐inhibition, and immunoblotting experiments indicate that bumblebee venom and honeybee venom contain venom‐specific IgE‐binding epitopes. These results suggest that immunotherapy using honeybee venom may not be effective in all bumblebee venom‐allergic patients. Our experiments also revealed differences in IgE binding for venom from European and American bumblebees.

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Occupational allergy to bumble bee venom

Abstract: The clinical profile of anaphylactic reactions to bumble bees is described and successful immunotherapy with honey bee venom in seven bumble bee allergic patients is reported. The cause of the high frequency of sensitization to pollen in these patients is discussed.

Cited by 38 publications

References 5 publications

Bites and stings of medically important venomous arthropods

Bites and stings of medically important venomous arthropods

The Principle of Homologous Groups in Regulatory Affairs of Allergen Products – A Proposal

Allergy to bumblebee venom. II IgE cross‐reactivity between bumblebee and honeybee venom

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