Occupational allergic contact urticaria to tropomyosin from squid

Wilfinger, Daniel; Kuehn, Annette; Takacs, Szandra; Galli-Novak, Evgenia; Machan, Barbara; Aberer, Werner

doi:10.5414/alx02121e

Cited by 4 publications

(11 citation statements)

References 19 publications

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“…For clarification of a mould‐associated respiratory allergy anamnesis, prick testing or serological IgE determination are recommended according to the diagnostic allergy algorithm (Figure 71). Since more and more mould test solutions are being withdrawn from the market, 867 serological IgE determination is almost the only test tool available, although it is often less sensitive than skin prick tests 1383 . In principle any mould can cause IgE sensitization and the exact determination of mould exposure is not possible in most cases.…”

Section: B07 – Allergy To Mouldsmentioning

confidence: 99%

“…In principle any mould can cause IgE sensitization and the exact determination of mould exposure is not possible in most cases. In vitro testing of a mould mixture (mx1) consisting of Alternaria alternata, Cladosporium herbarum, Aspergillus fumigatus and Pencillium chrysogenum was shown to be sufficient to detect IgE reactions to all the contained individual mould species 868,1383 . If mould‐associated IgE is measurable, a possible exposure should be verified anamnestically (indoor versus outdoor) and possible co‐sensitizations such as grass pollen or house dust mites, which represent overlapping allergen exposures, must be investigated (Figure 71).…”

Section: B07 – Allergy To Mouldsmentioning

confidence: 99%

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EAACIMolecular Allergology User's Guide 2.0

Dramburg

Hilger

Santos

et al. 2023

Pediatric Allergy Immunology

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Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967, our knowledge about the immunological mechanisms of IgE‐mediated allergies has remarkably increased. In addition to understanding the immune response and clinical symptoms, allergy diagnosis and management depend strongly on the precise identification of the elicitors of the IgE‐mediated allergic reaction. In the past four decades, innovations in bioscience and technology have facilitated the identification and production of well‐defined, highly pure molecules for component‐resolved diagnosis (CRD), allowing a personalized diagnosis and management of the allergic disease for individual patients. The first edition of the “EAACI Molecular Allergology User's Guide” (MAUG) in 2016 rapidly became a key reference for clinicians, scientists, and interested readers with a background in allergology, immunology, biology, and medicine. Nevertheless, the field of molecular allergology is moving fast, and after 6 years, a new EAACI Taskforce was established to provide an updated document. The Molecular Allergology User's Guide 2.0 summarizes state‐of‐the‐art information on allergen molecules, their clinical relevance, and their application in diagnostic algorithms for clinical practice. It is designed for both, clinicians and scientists, guiding health care professionals through the overwhelming list of different allergen molecules available for testing. Further, it provides diagnostic algorithms on the clinical relevance of allergenic molecules and gives an overview of their biology, the basic mechanisms of test formats, and the application of tests to measure allergen exposure.

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Section: B07 – Allergy To Mouldsmentioning

confidence: 99%

Section: B07 – Allergy To Mouldsmentioning

confidence: 99%

EAACIMolecular Allergology User's Guide 2.0

Dramburg

Hilger

Santos

et al. 2023

Pediatric Allergy Immunology

Self Cite

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“…An example of this is the report of occupational asthma in a seafood restaurant worker who developed urticaria and asthma after being in contact with shrimp and scallops. 23 Another case is of a cook's mate working 3 in an Austrian restaurant who reported acutely occurring urticarial skin lesions after processing and cooking squid. Both patients 23,3 were diagnosed with a clinically and occupationally type I allergy to tropomyosin with…”

Section: E146mentioning

confidence: 99%

“…23 Another case is of a cook's mate working 3 in an Austrian restaurant who reported acutely occurring urticarial skin lesions after processing and cooking squid. Both patients 23,3 were diagnosed with a clinically and occupationally type I allergy to tropomyosin with…”

Section: E146mentioning

confidence: 99%

“…Worldwide, fish and seafood are among the list of the most frequent triggers of IgE-mediated food allergic reactions in both children and adults, and constitute an important and increasing health issue. 3 Parvalbumins have been identified as the major fish allergen, whereas tropomyosin has been recognized as the main allergen for seafood allergy. 4 Tropomyosin belongs to a group of proteins called panallergens.…”

mentioning

confidence: 99%

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Tropomyosin: A panallergen that causes a worldwide allergic problem

Papia

Bellia

Uasuf

2021

allergy asthma proc

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Background: Panallergens are proteins that take part in key processes of organisms and, therefore, are ubiquitously distributed with highly conserved sequences and structures. One class of these panallergens is composed of the tropomyosins. The highly heat-stable tropomyosins comprise the major allergens in crustaceans and mollusks, which make them important food allergens in exposed populations. Tropomyosins are responsible for a widespread immunoglobulin E cross-reactivity among allergens from different sources. Allergic tropomyosins are expressed in many species, including parasites and insects. Methods: This panallergen class is divided, according to it capacity of induced allergic symptoms, into allergenic or nonallergenic tropomyosin. Although vertebrate tropomyosins share ∼55% of sequence homology with invertebrate tropomyosins, it has been thought that the invertebrate tropomyosins would not have allergic properties. Nevertheless, in recent years, this opinion has been changed. In particular, tropomyosin has been recognized as a major allergen in many insects. Results: A high grade of homology has been shown among tropomyosins from different species, such as crustaceans and insects, which supports the hypothesis of cross-reactivity among tropomyosins from divergent species. Moreover, the emerging habit of consuming edible insects has drawn the attention of allergists to invertebrate tropomyosin protein due to its potential allergenic risk. Nevertheless, evidence about tropomyosin involvement in clinical allergic response is still scarce and deserves more investigation. Conclusion: This review intended to report allergic reactions associated with different tropomyosins when considering house dust mites, parasites, seafood, and insects, and to summarize our current knowledge about its cross-reactivity because this could help physicians to accurately diagnose patients with food allergy.

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