Occupational allergic contact dermatitis from tetrazepam in nurses

Hulst, Kim Vander; Kerre, Stefan; Goossens, An

doi:10.1111/j.1600-0536.2010.01699.x

Cited by 27 publications

(3 citation statements)

References 18 publications

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“…In this study, we did not examine the health effects of chronic exposures to PM from pill crushing, but studies have shown correlations between crushing benzodiazepine, beta-blockers, ACE inhibitors, trazodone, ranitidine, and zolpidem and the development of airborne occupational contact dermatitis in nurses (Gilissen et al, 2020; Hulst et al, 2010; Swinnen et al, 2014). It is critical to note that allergic reactions may result from exposure to inactive ingredients of oral medications (Abrantes et al, 2016; Kelso, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Her symptoms continued for several months but resolved when exposure to clozapine powder was stopped (Lewis et al, 2012). Multiple studies show the correlation between crushing benzodiazepine medications and nurse development of airborne occupational contact dermatitis (Gilissen et al, 2020; Hulst et al, 2010; Swinnen et al, 2014), but other drugs have also been correlated with contact dermatitis, such as beta-blockers, Angiotensin-converting enzyme (ACE) inhibitors, trazodone, ranitidine, and zolpidem (Gilissen et al, 2020; Swinnen et al, 2014). The allergic reactions might result from exposure to inactive ingredients of oral medications (Abrantes et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

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Using Fume Hood to Reduce Nurses’ Exposure to Particulate Matters Dispersed Into the Air During Pill Crushing

Amiri,

Guess,

Gilder

et al. 2023

Workplace Health Saf

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Background: Pill crushing is a common practice in patient care settings. Crushing pills can disperse particulate matter (PM) into indoor air. The PM is a widespread air pollutant composed of microscopic particles and droplets of various sizes and may carry active and/or inactive ingredients nurses can inhale. This study aimed to quantify PM sizes and concentration in indoor air when pills are crushed and examine the role of a fume hood in reducing particulate pollution. Methods: Two scenarios (with and without a fume hood) representing nurses’ pill-crushing behaviors were set up in a positive-pressure cleanroom. Two acetaminophen tablets (325 mg/tablet) were crushed into powder and mixed with unsweetened applesauce. The PM sizes and concentrations were measured before and during crushing. Results: Different sizes of PM, including inhalable, respirable, and thoracic particles, were emitted during medication crushing. The total count of all particle sizes and mass concentrations of particles were significantly lower during crushing when a fume hood was used ( p = .00). Conclusion: Pill crushing increases PM and should be considered a workplace safety health hazard for nurses. Healthcare professionals should work under a fume hood when crushing pills and wear proper protective equipment. The findings of significant particulate pollution related to pill crushing suggest that further research is warranted.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Using Fume Hood to Reduce Nurses’ Exposure to Particulate Matters Dispersed Into the Air During Pill Crushing

Amiri,

Guess,

Gilder

et al. 2023

Workplace Health Saf

View full text Add to dashboard Cite

show abstract

“…In particular, tetrazepam has triggered hand and facial dermatitis [27,28]. Of note, there may be significant cross-sensitization to other benzodiazepines, which in turn demonstrates the importance of through patch testing and consideration of cross-reactors.…”

Section: Medicationsmentioning

confidence: 99%