Occupational airborne contact dermatitis to simvastatin, carvedilol, and zolpidem

Occupational airborne contact dermatitis from benzodiazepines and other drugs

“…Moreover, we also observed positive reactions to non‐related drugs (Table ): in 3 cases to trazodone hydrochloride, an antidepressant, and in 5 cases to zolpidem, an imidazopyridine sedative hypnotic used for the treatment of insomnia and described as an occupational allergen in the pharmaceutical industry . As zolpidem and trazodone are often used in association with tetrazepam in the same patient population, concomitant or subsequent sensitization in healthcare workers cannot always be ruled out completely, even when contact with them is sometimes denied.…”

A study of occupational contact dermatitis in the pharmaceutical industry

“…One of the patients was found to have contact allergy to olanzapine (the third reported case), another to simvastatin (the fifth reported case) and another, as previously reported in three cases, to bibea (a precursor component of atorvastatin) . We identified three cases of omeprazole allergy, which has been reported in four other cases .…”

Occupational allergic contact dermatitis from systemic drugs

“…Its high sensitizing potential and the severe drug eruptions via systemic exposure, in particular, have been the reason for its withdrawal from the market in May 24, 2013 This probably explains why the last case observed was in 2010. Interestingly, four tetrazepam‐allergic nurses concomitantly reacted to zolpidem, a non‐benzodiazepine hypnotic drug, which has been previously described as a potential allergen in the pharmaceutical industry and the health‐care sector …”

“…Interestingly, four tetrazepam-allergic nurses concomitantly reacted to zolpidem, a non-benzodiazepine hypnotic drug, 17 which has been previously described as a potential allergen in the pharmaceutical industry and the health-care sector. 25 Five positive patch tests were observed to ranitidine hydrochloride, the last case being diagnosed in 2011. In accordance with the literature, nurses used to be more frequently affected, 6,17 but one article describes six cases from the same pharmaceutical company.…”