Occupation exposures and sperm morphology: a case-referent analysis of a multi-centre study

Cherry, Nicola; Povey, A.; McNamee, Roseanne; Moore, H. D. M.; Baillie, Helen; Clyma, J.- A.; Dippnall, Martin; Pacey, Allan

doi:10.1136/oemed-2013-101996

Cited by 15 publications

(7 citation statements)

References 31 publications

(39 reference statements)

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“…Pacey et al [ 77 ] indicated that modifiable lifestyle factors such as obesity, smoking or alcohol intake/consumption have little effect on the percentage of sperm morphology. Similarly, Cherry et al [ 78 ] examined the occupational exposures of 2,011 men attending infertility clinics across the UK and failed to find any significant relation with sperm morphology. Several other studies reported a significant negative impact of alcohol and smoking on various semen parameters including sperm morphology [ 79 80 81 ].…”

Section: General Treatment Modalities For Abnormal Sperm Morphologymentioning

confidence: 99%

Sperm Morphology Assessment in the Era of Intracytoplasmic Sperm Injection: Reliable Results Require Focus on Standardization, Quality Control, and Training

Agarwal

Sharma

Gupta

et al. 2022

World J Mens Health

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Semen analysis is the first, and frequently, the only step in the evaluation of male fertility. Although the laboratory procedures are conducted according to the World Health Organization (WHO) guidelines, semen analysis and especially sperm morphology assessment is very difficult to standardize and obtain reproducible results. This is mainly due to the highly subjective nature of their evaluation. ICSI is the choice of treatment when sperm morphology is severely abnormal (teratozoospermic). Hence, the standardization of laboratory protocols for sperm morphology evaluation represents a fundamental step to ensure reliable, accurate and consistent laboratory results that avoid misdiagnoses and inadequate treatment of the infertile patient. This article aims to promote standardized laboratory procedures for an accurate evaluation of sperm morphology, including the establishment of quality control and quality assurance policies. Additionally, the clinical importance of sperm morphology results in assisted reproductive outcomes is discussed, along with the clinical management of teratozoospermic patients.

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Section: General Treatment Modalities For Abnormal Sperm Morphologymentioning

confidence: 99%

Sperm Morphology Assessment in the Era of Intracytoplasmic Sperm Injection: Reliable Results Require Focus on Standardization, Quality Control, and Training

Agarwal

Sharma

Gupta

et al. 2022

World J Mens Health

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“…No systematic reviews or meta-analyses have been performed, which is probably because of the significant variation in study design. The available studies use different ages of participants, different outcomes, subjective definitions of heat exposure, and even different criteria for semen analysis ( Zorgniotti & Seaflon, 1988 and Cherry et al , 2014 ).…”

Section: Summary Of Outcomes and Narrative Review As Related To The Ementioning

confidence: 99%

The diagnosis of male infertility: an analysis of the evidence to support the development of global WHO guidance—challenges and future research opportunities

Barratt

Björndahl

Jonge

et al. 2017

Human Reproduction Update

358

227

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BACKGROUNDHerein, we describe the consensus guideline methodology, summarize the evidence-based recommendations we provided to the World Health Organization (WHO) for their consideration in the development of global guidance and present a narrative review of the diagnosis of male infertility as related to the eight prioritized (problem or population (P), intervention (I), comparison (C) and outcome(s) (O) (PICO)) questions. Additionally, we discuss the challenges and research gaps identified during the synthesis of this evidence.OBJECTIVE AND RATIONALEThe aim of this paper is to present an evidence-based approach for the diagnosis of male infertility as related to the eight prioritized PICO questions.SEARCH METHODSCollating the evidence to support providing recommendations involved a collaborative process as developed by WHO, namely: identification of priority questions and critical outcomes; retrieval of up-to-date evidence and existing guidelines; assessment and synthesis of the evidence; and the formulation of draft recommendations to be used for reaching consensus with a wide range of global stakeholders. For each draft recommendation the quality of the supporting evidence was then graded and assessed for consideration during a WHO consensus.OUTCOMESEvidence was synthesized and recommendations were drafted to address the diagnosis of male infertility specifically encompassing the following: What is the prevalence of male infertility and what proportion of infertility is attributable to the male? Is it necessary for all infertile men to undergo a thorough evaluation? What is the clinical (ART/non ART) value of traditional semen parameters? What key male lifestyle factors impact on fertility (focusing on obesity, heat and tobacco smoking)? Do supplementary oral antioxidants or herbal therapies significantly influence fertility outcomes for infertile men? What are the evidence-based criteria for genetic screening of infertile men? How does a history of neoplasia and related treatments in the male impact on (his and his partner's) reproductive health and fertility options? And lastly, what is the impact of varicocele on male fertility and does correction of varicocele improve semen parameters and/or fertility?WIDER IMPLICATIONSThis evidence synthesis analysis has been conducted in a manner to be considered for global applicability for the diagnosis of male infertility.

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“…As such, for most men, healthcare professionals can only focus on delivering general advice to highlight the known lifestyle risks for poor sperm quality. For example, epidemiological studies have shown how certain occupations [5,6], the wearing of tight underwear [7,8], tobacco smoking [9], high body mass index (BMI) [10] and recreational drug use [11] are each associated with aspects of poor sperm quality.…”

Section: Introductionmentioning

confidence: 99%

A randomized placebo-controlled trial to investigate the effect of lactolycopene on semen quality in healthy males

et al. 2019

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Purpose Poor sperm quality is a major contributor to infertility in heterosexual couples, but at present there are few empirical therapies. Several studies have examined the role of dietary factors and data from randomized controlled trials suggest that oral antioxidant therapy can improve some sperm parameters. Health benefits of lycopene supplementation have been proposed for a variety of health conditions and here we examine whether it can help improve sperm quality. This study aimed to investigate the effect of 14 mg daily lactolycopene for 12 weeks on semen quality in healthy men. Methods Sixty healthy male participants were recruited and randomized to this double-blind, placebo-controlled parallel study and received either 14 mg/d lactolycopene or a placebo for 12 weeks. The primary endpoint was a change in motile sperm concentration. Secondary endpoints were all other aspects of sperm quality, including the level of sperm DNA damage. Results Fifty-six men completed the intervention and the level of plasma lycopene was significantly increased in the men randomized to receive lycopene supplementation. There was no significant change in the primary endpoint (motile sperm concentration) post-intervention (p = 0.058). However, the proportion of fast progressive sperm (p = 0.006) and sperm with normal morphology (p < 0.001) did improve significantly in response to lactolycopene intervention. Conclusions Supplementation with 14 mg/d lactolycopene improves sperm motility and morphology in young healthy men. Clinical Trial Registry number and website ISRCTN33248724 http://www.isrctn.com/ISRCTN33248724

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Occupation exposures and sperm morphology: a case-referent analysis of a multi-centre study

Abstract: While this study did not identify any occupational exposure uniquely related to sperm morphology, the capacity of the study to detect risk was increased by including morphology with sperm concentration and motility.

Cited by 15 publications

References 31 publications

Sperm Morphology Assessment in the Era of Intracytoplasmic Sperm Injection: Reliable Results Require Focus on Standardization, Quality Control, and Training

Sperm Morphology Assessment in the Era of Intracytoplasmic Sperm Injection: Reliable Results Require Focus on Standardization, Quality Control, and Training

The diagnosis of male infertility: an analysis of the evidence to support the development of global WHO guidance—challenges and future research opportunities

A randomized placebo-controlled trial to investigate the effect of lactolycopene on semen quality in healthy males

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