Occupation and risk of upper aerodigestive tract cancer: The ARCAGE study

Richiardi, Lorenzo; Corbin, Marine; Marron, Manuela; Ahrens, Wolfgang; Pohlabeln, Hermann; Λάγιου, Παγώνα; Minaki, Ploumitsa; Agudo, Antonio; Castellsagué, Xavier; Slámová, Alena; Schejbalová, Miriam; Kjærheim, Kristina; Barzan, Luigi; Talamini, Renato; Macfarlane, Gary J.; Macfarlane, Tatiana V.; Canova, Cristina; Simonato, Lorenzo; Conway, David I.; McKinney, Patricia A.; Sneddon, Linda; Thomson, Peter; Znaor, Ariana; Healy, Claire M.; McCartan, Bernard E.; Benhamou, Simone; Bouchardy, Christine; Hashibe, Mia; Brennan, Paul; Merletti, Franco

doi:10.1002/ijc.26237

Cited by 35 publications

(36 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For gastric cancer jobs in the following industries were classified as exposure: asbestos, painters, inorganic lead, rubber industry, miners and quarrymen, farmers, fishermen, masonry and concrete workers, machine operators, nurses, food industry workers, cooks, launderers and dry cleaners . For UADT cancers the respective industries were: construction, including reinforced concreters, bricklayers, painters and workers employed in the construction of roads or the erection of roofs . Model 3 (the main model) was in addition adjusted for area‐level SES (for residential neighborhood or similar).…”

Section: Methodsmentioning

confidence: 99%

Air pollution and incidence of cancers of the stomach and the upper aerodigestive tract in the European Study of Cohorts for Air Pollution Effects (ESCAPE)

Nagel

Stafoggia

Pedersen

et al. 2018

Intl Journal of Cancer

View full text Add to dashboard Cite

Air pollution has been classified as carcinogenic to humans. However, to date little is known about the relevance for cancers of the stomach and upper aerodigestive tract (UADT). We investigated the association of long-term exposure to ambient air pollution with incidence of gastric and UADT cancer in 11 European cohorts. Air pollution exposure was assigned by land-use regression models for particulate matter (PM) below 10 µm (PM ), below 2.5 µm (PM ), between 2.5 and 10 µm (PM ), PM absorbance and nitrogen oxides (NO and NO ) as well as approximated by traffic indicators. Cox regression models with adjustment for potential confounders were used for cohort-specific analyses. Combined estimates were determined with random effects meta-analyses. During average follow-up of 14.1 years of 305,551 individuals, 744 incident cases of gastric cancer and 933 of UADT cancer occurred. The hazard ratio for an increase of 5 µg/m of PM was 1.38 (95% CI 0.99; 1.92) for gastric and 1.05 (95% CI 0.62; 1.77) for UADT cancers. No associations were found for any of the other exposures considered. Adjustment for additional confounders and restriction to study participants with stable addresses did not influence markedly the effect estimate for PM and gastric cancer. Higher estimated risks of gastric cancer associated with PM was found in men (HR 1.98 [1.30; 3.01]) as compared to women (HR 0.85 [0.5; 1.45]). This large multicentre cohort study shows an association between long-term exposure to PM and gastric cancer, but not UADT cancers, suggesting that air pollution may contribute to gastric cancer risk.

show abstract

Section: Methodsmentioning

confidence: 99%

Air pollution and incidence of cancers of the stomach and the upper aerodigestive tract in the European Study of Cohorts for Air Pollution Effects (ESCAPE)

Nagel

Stafoggia

Pedersen

et al. 2018

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…Thus, some occupations in men5–17 and women14 18–21 were associated with the risk of developing head and neck cancer.…”

Section: Introductionmentioning

confidence: 99%

Occupational exposure to solvents and risk of head and neck cancer in women: a population-based case–control study in France

et al. 2017

View full text Add to dashboard Cite

ObjectiveOur objective was to investigate the association between head and neck cancer and occupational exposure to chlorinated, oxygenated and petroleum solvents in women.MethodsInvestigation of occupational and environmental CAuses of REspiratory cancers (ICARE), a French population-based case–control study, included 296 squamous cell carcinomas of the head and neck (HNSCC) in women and 775 female controls. Lifelong occupational history was collected. Job-exposure matrices allowed to assess exposure to 5 chlorinated solvents (carbon tetrachloride; chloroform; methylene chloride; perchloroethylene; trichloroethylene), 5 petroleum solvents (benzene; special petroleum product; gasoline; white spirits and other light aromatic mixtures; diesel, fuels and kerosene) and 5 oxygenated solvents (alcohols; ketones and esters; ethylene glycol; diethyl ether; tetrahydrofuran). OR and 95% CIs, adjusted for smoking, alcohol drinking, age and geographical area, were estimated with logistic models.ResultsElevated ORs were observed among women ever exposed to perchloroethylene (OR=2.97, 95% CI 1.05 to 8.45) and trichloroethylene (OR=2.15, 95% CI 1.21 to 3.81). These ORs increased with exposure duration (OR=3.75, 95% CI 0.64 to 21.9 and OR=4.44, 95% CI 1.56 to 12.6 for 10 years or more, respectively). No significantly increased risk of HNSCC was found for occupational exposure to the other chlorinated, petroleum or oxygenated solvents.ConclusionsThese findings suggest that exposure to perchloroethylene or trichloroethylene may increase the risk of HNSCC in women. In our study, there is no clear evidence that the other studied solvents are risk factors for HNSCC.

show abstract

“…Chronic trauma to the oral mucosa from poor restorations and prostheses, as well as poor oral hygiene with a consequent heavy bacterial load in the mouth, are reemerging as significant risk factors [14][15][16] . Further, some epidemiological studies show that employment in industries with occupational exposures to wood dust, asbestos, acid mists or solvents as well as manufacturing of textiles and leather are associated with an increased risk of HNSCC [17][18][19][20] . When not considering HNC related to HPV, these cancers are predominantly a disease of the poorer sections of society [21] .…”

Section: Risk Factorsmentioning

confidence: 99%

Global Epidemiology of Head and Neck Cancers: A Continuing Challenge

Gupta

Johnson

Kumar³

2016

Oncology

370

253

View full text Add to dashboard Cite

Background: Head and neck cancers (HNCs) continue to remain a significant public health burden worldwide, causing significant mortality and morbidity despite significant clinical advances enabling their early diagnosis and treatment. Methods: We used data from the GLOBOCAN 2012, Cancer Incidence in Five Continents, World Health Organization Mortality Database and Surveillance, Epidemiology, and End Results programmes to describe the current epidemiology of HNCs. Results: Estimated age-standardised incidence/mortality rates for cancers of the lip and oral cavity among males and females (7.0/2.3 and 2.6/0.6 per 100,000 per annum) in more developed regions are higher compared to those in less developed regions (5.0/2.8 and 2.5/1.4 per 100,000 per annum). Similarly, the estimated rates for cancers of the tonsils and pharynx among males (7.5/2.5 per 100,000 per annum) and females (2.7/0.5 per 100,000 per annum) are reported to be the highest in Western Europe, whereas these rates for cancer of the larynx among males (7.9/4.0 per 100,000 per annum) and females (0.9/0.5 per 100,000 per annum) are reported to be the highest in the Caribbean. Cancer of the nasopharynx represents a significant HNC burden in the Asia-Pacific region and Northern Africa. Conclusion: The current and future estimated burden of HNCs is shifting to less developed regions which may be ill equipped to deal with this increasing burden. This needs urgent attention of policy makers through effective cancer control policy implementation with population-based interventions.

show abstract

Occupation and risk of upper aerodigestive tract cancer: The ARCAGE study

Cited by 35 publications

References 40 publications

Air pollution and incidence of cancers of the stomach and the upper aerodigestive tract in the European Study of Cohorts for Air Pollution Effects (ESCAPE)

Air pollution and incidence of cancers of the stomach and the upper aerodigestive tract in the European Study of Cohorts for Air Pollution Effects (ESCAPE)

Occupational exposure to solvents and risk of head and neck cancer in women: a population-based case–control study in France

Global Epidemiology of Head and Neck Cancers: A Continuing Challenge

Contact Info

Product

Resources

About