Occult Transitional Cell Carcinoma of the Prostate Presenting as Skin Metastasis

Razvi, Mohammed; Firfer, Raymond; Berkson, Bruce M.

doi:10.1016/s0022-5347(17)59568-3

Cited by 20 publications

(9 citation statements)

References 4 publications

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“…[95][96][97] Primary urothelial carcinoma presents in a manner similar to other prostatic masses including urinary obstruction and hematuria. 90,98 Digital rectal examination is abnormal in the majority, but is infrequently the presenting sign. 99 There are limited data on PSA levels in patients with urothelial carcinoma of the prostate.…”

Section: Urothelial (Transitional Cell) Carcinomamentioning

confidence: 99%

“…99 In some cases, patients present with signs and symptoms related to metastases. 98 Most cases are diagnosed by TUR or less often needle biopsy. 99 In all suspected cases, the possibility of secondary involvement from a bladder primary must be excluded; the bladder tumor can be occult and random biopsies of urinary bladder mucosa may be necessary to exclude this possibility.…”

Section: Urothelial (Transitional Cell) Carcinomamentioning

confidence: 99%

“…96 The vast majority, however, are of high grade and are associated with an in situ component. 99,98,[103][104][105][106][107] The in situ component has the characteristic histologic features of urothelial carcinoma in situ elsewhere with marked nuclear pleomorphism, frequent mitoses and apoptotic bodies (Figure 17). A single cell pattern of pagetoid spread or burrowing of tumor cells between the basal cell and secretory cell layers of the prostate is characteristic (Figure 18).…”

Section: Urothelial (Transitional Cell) Carcinomamentioning

confidence: 99%

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Unusual subtypes of prostate cancer

2004

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The vast majority of prostatic tumors developing in adult males are adenocarcinomas. For the most part, variations in histology have not received specific designations and, from a practical approach, have had any specific prognostic implications handled through application of the Gleason grading system. Nonetheless, some of the adenocarcinoma variants have specific clinical features and differential diagnoses. Furthermore, there has been some controversy regarding the appropriate application of the Gleason grading scheme in these tumors. In addition, there are carcinomas that are in fact not adenocarcinomas and that should be kept as distinct entities. In this paper, the histologic variants of adenocarcinoma are reviewed with emphasis on clinicopathologic features and the clinical relevance of these subtypes. Other carcinomas that occur in the prostate gland are also discussed again with a focus on the clinicopathologic characteristics.

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Section: Urothelial (Transitional Cell) Carcinomamentioning

confidence: 99%

Section: Urothelial (Transitional Cell) Carcinomamentioning

confidence: 99%

Section: Urothelial (Transitional Cell) Carcinomamentioning

confidence: 99%

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Unusual subtypes of prostate cancer

2004

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“…Rectal examination may reveal a benign or normal prostate gland in up to 50% of cases.2.6 Furthermore, transurethral biopsy is more likely to yield a positive diagnosis than transrectal or perineal Additional clinical features more commonly found in TCC include normal serum acid phosphatase levels and the presence of osteolytic as well as osteoblastic bone metastases.2. 6 TCC of the prostate may be difficult to differentiate pathologically from transitional cell carcinoma of the bladder with secondary invasion of or recurrence in the prostate, from primary carcinoma of the urethra and from generalized urothelial carcinoma in sitx6-" A negative cystoscopic examination is crucial to the diagnosis of TCC.'.'' In some cases histologic examination may reveal a mixture of transitional cell carcinoma and adenocarcinoma.6.…”

Section: Discussionmentioning

confidence: 99%

Transitional cell carcinoma of the prostate. Response to treatment with adriamycin and cis-platinum

Taylor

Blom

1983

Cancer

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“…(B, bottom) High-power view of anaplastic cells (X350).tients with long-standing, recurrent hematuria may develop positive urine cytology as the earliest manifestation of TCC.''.' Rectal examination may reveal a benign or normal prostate gland in up to 50% of cases.2.6 Furthermore, transurethral biopsy is more likely to yield a positive diagnosis than transrectal or perineal Additional clinical features more commonly found in TCC include normal serum acid phosphatase levels and the presence of osteolytic as well as osteoblastic bone metastases.2 6. TCC of the prostate may be difficult to differentiate pathologically from transitional cell carcinoma of the 1801 bladder with secondary invasion of or recurrence in the prostate, from primary carcinoma of the urethra and from generalized urothelial carcinoma in sitx6-" A negative cystoscopic examination is crucial to the diagnosis of TCC.'.''…”

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confidence: 99%

Transitional Cell Carcinoma of the Prostate: Response to Treatment with Adriamycin and Cis-Platinum

Taylor

Blom

1984

Journal of Urology

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A patient with metastatic transitional cell carcinoma of the prostate achieved an impressive clinical response to treatment with Adriamycin and cis-platinum. The treatment of transitional cell carcinoma of the prostate is discussed and the literature is reviewed.Cancer 51:1800-1802. 1983. RANSITIONAL CELL CARCINOMA of the prostate T (TCC) comprises 2 to 3% of most large series of prostate cancer cases.'-3 This unusual tumor originates from the transitional cell layer of the periurethral prostatic ducts and may differ significantly in clinical characteristics in comparison to the more common adenocarcinoma arising from peripheral prostatic acinar glands.' Response to standard therapy is poor and survival in patients with metastatic TCC is limited.2.3.5.6 The present report describes our experience in the treatment of TCC in a patient with widespread metastatic disease who achieved an impressive clinical response following treatment with combination chemotherapy to include Adriamycin and cis-platinum. Case ReportA 65-year-old white man noted low back pain and hesitancy on urination seven months prior to evaluation. Rectal examination of the prostate revealed an enlarged gland. Serum acid phosphatase was normal. X-ray of lumbar spine demonstrated a lytic lesion at L-4 and subsequent cystoscopy and prostate biopsy revealed only inflammatory change. Transurethral resection demonstrated transitional cell carcinoma of the prostate (Figs. 1A and IB). Metastatic work-up included bone scan with numerous areas of increased uptake in spine, ribs and pelvis, and liver-spleen scan with hepatomegaly and multiple filling defects. The patient's clinical status deteriorated rapidly. He developed large, bilateral pleural and peri-* Hematology-Oncology Service, Walter Reed Army Medical Center, Washington, DC.

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Occult Transitional Cell Carcinoma of the Prostate Presenting as Skin Metastasis

Cited by 20 publications

References 4 publications

Unusual subtypes of prostate cancer

Unusual subtypes of prostate cancer

Transitional cell carcinoma of the prostate. Response to treatment with adriamycin and cis-platinum

Transitional Cell Carcinoma of the Prostate: Response to Treatment with Adriamycin and Cis-Platinum

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