Occult metastasis in early ovarian cancers: risk factors and associated prognosis

Debulking surgery for incompletely operated advanced epithelial ovarian carcinoma

“…Despite this high frequency, the prognostic role of IIS history has not been previously analyzed in the published literature, particularly in advanced stages. Previous reports have focused on the role of re-staging and up-staging in early stages [3][4][5][6][7][8][9][10]. What about the advanced stages?…”

“…Journal of Surgical Oncology 6) Re-operation and re-debulking surgery (secondary MDS) for the incompletely operated patients (IIS), which is the subject of this analysis and which was never analyzed previously in the published literature [3][4][5][6][7][8][9][10].…”

“…Despite the well known evidence in early stage ovarian cancer patients, we are aware of no data on the role of secondary MDS in patients with advanced stage disease or prognostic factors for these patients [3][4][5][6][7][8][9][10]. Two previous studies, EORTC/GCCG-55865 and GOG-152 had analyzed the role of re-surgery in these advanced staged patients [11,12].…”

“…None of the patients had received preoperative chemotherapy before secondary MDS. Therefore, this study is not an interval debulking (IDS) or neoadjuvant chemotherapy (NAC) trial [3][4][5][6][7][8][9][10][11][12]. In this report, we determined to analyze whether an incomplete primary surgery followed by secondary MDS affected prognosis and the factors involved.…”

Clinical outcomes of fertility-sparing treatments in young patients with epithelial ovarian carcinoma

“…A multivariate analysis of 164 early stage EOC patients revealed that there were three factors related to occult metastasis: CA125 levels over 500 U/ml, positive peritoneal cytology, and Grade 3 disease (Ayhan et al, 2007). Multivariate analyses (Vergote et al, 2001) identified that, except for histological grade, none of the following were of prognostic value: histological type, dense adhesion, extracapsular growth, ascites, FIGO stage, and size of tumour.…”