Occult lymph node metastasis in laryngeal squamous cell carcinoma: Therapeutic and prognostic impact

Abstract

Level IIb or IV involvement is rare. Superselective neck dissection (IIa, III) seems to be indicated in T1T2 N0 tumor. In case of advanced tumor or pre-epiglottic space or cartilage invasion, functional neck dissection is mandatory.

Detection of Cervical Lymph Node Micrometastases in Patients with Squamous Cell Carcinoma of the Oral Cavity, Pharynx and Larynx

“…Many authors in recent years have focused on detection of HNSCC micrometastases using immunohistochemical methods. Positive results in patients with clinical N0 stage varies widely from 2 to 58% (13)(14)(15)(16)(17)(18), which indicates that the methods for detection are not united and the percentage of positive results depends on the experience of the pathologist. In our study, micrometastases or ITC were detected in 5 cases (42%), 4 patients (33%) had a metastases of SCC and 1 patient (9%) had an accidental finding of PTC micrometastasis.…”

Intratumoral lymphatic vessel density as a predictor of progression‐free and overall survival in locally advanced laryngeal/hypopharyngeal cancer

“…Lymph node metastases have been shown to be a strong predictor of prognosis in HNSCC, including in laryngeal carcinoma . Currently, lymphangiogenesis, lymphatic vessel remodeling, and lymphatic metastasis are active ongoing areas of research .…”

“…Lymph node metastases have been shown to be a strong predictor of prognosis in HNSCC, including in laryngeal carcinoma. 1,3,20 Currently, lymphangiogenesis, lymphatic vessel remodeling, and lymphatic metastasis are active ongoing areas of research. 12,21 The prognostic significance of tumor lymphatics, both peritumoral and intratumoral, is an important question to understand as a greater knowledge of this process could lead to improved stratification of patient therapies.…”

Investigation of recurrence risk in laryngeal cancer following laser surgery

“…The general prognostic factors in larynx tumors are believed to be tumor stage, anatomical location, histological differentiation and the presence of neck metastasis, but especially the presence of neck metastasis is considered to be the most important factor showing a poor prognosis [7]. Tumor development is in close association with various genetic disorders of protooncogenes and tumor suppressor genes [8,9].…”