Occult hepatitis B virus infection does not affect liver histology or response to therapy with interferon alpha and ribavirin in intravenous drug users with chronic hepatitis C

Fabris, Paolo; Brown, Dave; Tositti, Giulia; Bozzola, L.; Giordani, Maria Teresa; Bevilacqua, P.; Lalla, Fausto de; Webster, George; Dusheiko, Geoffrey

doi:10.1016/s1386-6532(03)00117-3

Cited by 58 publications

(97 citation statements)

References 44 publications

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“…The prevalence of occult B infection in HCV-infected patients in the present study (19.5%) was above the one reported by some authors (9,12) and below the percentages reported by others (21,28,36,38) , which can be as high as 76% (24) . It should be highlighted that the latter studies used PCR for viral DNA detection, a technique which is more sensitive than immunohistochemistry (4,12) .…”

Section: Discussioncontrasting

confidence: 73%

“…It should be highlighted that the latter studies used PCR for viral DNA detection, a technique which is more sensitive than immunohistochemistry (4,12) . It is not well established if failure to detect HBV antigens by immunohistochemistry in a few patients with occult B infection (9,28) is solely related to low viral replication, or if variations in samples size and the presence of viral mutations may play a role in these results.…”

Section: Discussionmentioning

confidence: 99%

“…MARISCAL et al (28) suggesting that the presence of HBV inhibits HCV replication. Nevertheless, the fi ndings about HCV viral load in the presence of HBV reported in the literature are confl icting (9,12,13,40) .…”

Section: Discussionmentioning

confidence: 99%

“…The immunologic signal of the presence of antigens was detected by a system based on streptoavidin-biotin complex HRP (Dako). Positive and negative controls were used in each session (12,17) .…”

Section: Viral Markers In Liver Tissuementioning

confidence: 99%

“…Despite evidence that co-infection may accelerate the progress to liver disease (9,41) , be related to the emergence of HCC (34,37,38) , and adversely infl uence the response to HCV treatment (7,9,13,41) , other studies show that occult infection does not interfere with the natural history of the disorder in this population (12,15,16,22) .…”

Section: Introductionmentioning

confidence: 97%

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Occult hepatitis B virus infection in patients with chronic liver disease due to hepatitis C virus and hepatocellular carcinoma in Brazil

Branco

Mattos

Coral

et al. 2007

Arq. Gastroenterol.

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-Background -The prevalence and consequences of occult HBV infection in patients with chronic liver disease by HCV remain unknown. Aims -To evaluate the prevalence of occult HBV infection in a population of HCV-infected patients with hepatocellular carcinoma. Methods -The serum samples were tested for HBV DNA by nested PCR and liver tissue analysis was carried out using the immunohistochemical technique of 66 HBsAg-negative patients: 26 patients with chronic hepatitis by HCV (group 1), 20 with hepatocellular carcinoma related to chronic infection by HCV (group 2) and 20 with negative viral markers for hepatitis B and C (control group). Results -Occult HBV infection was diagnosed in the liver tissue of 9/46 (19.5%) HCV-infected patients. Prevalence of occult B infection was evaluated in the HCV-infected patients with and without hepatocellular carcinoma, and there were seven (77.7%) of whom from group 2, conferring a 35% prevalence of this group. No serum sample was positive for HBV DNA in the three groups. Conclusion -Occult infection B is frequently detected in liver tissue of HCV-infected patients, especially in cases of hepatocellular carcinoma. However large studies are needed to confi rm that co-infection could determine a worse progress of chronic liver disease in this population.

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Section: Discussioncontrasting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Viral Markers In Liver Tissuementioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

See 3 more Smart Citations

Occult hepatitis B virus infection in patients with chronic liver disease due to hepatitis C virus and hepatocellular carcinoma in Brazil

Branco

Mattos

Coral

et al. 2007

Arq. Gastroenterol.

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HCV persistence: Cure is still a four letter word

Feld

Liang

2004

Hepatology

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Hepatitis C — Identifying Patients with Progressive Liver Injury

Feld

Liang

2006

Hepatology

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Hepatitis C follows a variable course with some patients developing progressive liver fibrosis, cirrhosis and hepatocellular carcinoma, while others have minimal or no significant liver disease after decades of infection. Studies have identified both host and viral factors associated with disease progression. The importance of general factors such as age at infection, gender, immune status and alcohol consumption has long been recognized; however recently, polymorphisms in a wide array of genes have also been shown to be associated with progressive fibrosis. How specific viral proteins may contribute to disease progression has also been studied. This review highlights what is currently known about the factors associated with progressive liver injury in patients with hepatitis C. A greater understanding of the determinants of disease progression will hopefully lead to improved utilization of existing treatments and ultimately may aid in identification of new therapeutic targets. (HEPATOLOGY 2006;43:S194-S206.)

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Occult hepatitis B virus infection does not affect liver histology or response to therapy with interferon alpha and ribavirin in intravenous drug users with chronic hepatitis C

Cited by 58 publications

References 44 publications

Occult hepatitis B virus infection in patients with chronic liver disease due to hepatitis C virus and hepatocellular carcinoma in Brazil

Occult hepatitis B virus infection in patients with chronic liver disease due to hepatitis C virus and hepatocellular carcinoma in Brazil

HCV persistence: Cure is still a four letter word

Hepatitis C — Identifying Patients with Progressive Liver Injury

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