Occult germ cell tumour presenting as spontaneous intracerebral haemorrhage

Couce, Marta; Medina‐Flores, Rafael; Wong, Maria Pik; Chu, Charleen T.

doi:10.1111/j.1365-2559.2007.02673.x

Cited by 1 publication

(2 citation statements)

References 22 publications

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“…Cases of gestational, gonadal nongestational, or extragonadal primary choriocarcinomas in the liver, kidney, lung, or brain presenting with neurological impairment compatible with brain metastasis with intracranial hemorrhage have been reported . However, primary mediastinal choriocarcinoma is rare, and most often presents with symptoms such as coughing and chest pain .…”

Section: Discussionmentioning

confidence: 99%

“…Such aneurysms are postulated to occur because of partial destruction of the vessel wall occurring after necrotic tumor embolus lodges in the vessel. 10,11 Cases of gestational, 12 gonadal nongestational, 13 or extragonadal primary choriocarcinomas in the liver, 14 kidney, 15 lung, 16 or brain 17 presenting with neurological impairment compatible with brain metastasis with intracranial hemorrhage have been reported. [18][19][20][21][22] However, primary mediastinal choriocarcinoma is rare, and most often presents with symptoms such as coughing and chest pain.…”

Section: P a T H O L O G Ymentioning

confidence: 99%

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Incidental primary mediastinal choriocarcinoma diagnosed by endobronchial ultrasound‐guided fine needle aspiration in a patient presenting with transient ischemic attack and stroke

Francischetti

Cajigas

Suhrland

et al. 2017

Diagnostic Cytopathology

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We describe a case of a 41-year old male patient with no significant prior medical history who presents with symptoms of Transient Ischemic Attack and stroke. Magnetic Resonance Imaging (MRI) of the brain identified areas of ischemia in the left side, and angiography showed occlusion of the left Medial Cerebral Artery (MCA). Cardiac Transthoracic Echocardiogram (TTE) for stroke evaluation incidentally noted a mediastinal abnormality leading to cancer work-up. Computer Tomography (CT) and F-fluorodeoxyglucose (FDG) PET-CT scan of the chest incidentally revealed an avid 6 cm paraesophagial/subcarinal mass. Further diagnostic work-up with endoscopic and endobronchial ultra sound (EBUS)-guided fine needle aspiration (FNA) of the mass yielded a cytology diagnosis of Germ Cell Tumor (GCT), with choriocarcinoma component. Additionally, high plasma levels of β-human chorionic gonadotrophin (β-HCG) were detected with no evidence of testicular tumor. This exceedingly rare presentation for a primary mediastinal choriocarcinoma underscores the importance of complete investigation of young patients presenting with neurological symptoms compatible with ischemic events. Diagn. Cytopathol. 2017;45:738-743. © 2017 Wiley Periodicals, Inc.

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