Occult chlamydial ophthalmia in men with non-gonococcal urethritis.

Monteiro, E F; Bradbury, J A; O’Donnell, Margaret; Rennie, I G; Kinghorn, G R

doi:10.1136/bmj.294.6568.349

Cited by 3 publications

(4 citation statements)

References 5 publications

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“…The reliability of Chlamydiazyme EIA for con junctival samples has been documented in neonatal chlamydial conjunctivitis [8,9]. We could not confirm the results of two earlier studies [2,3]. One explanation is that the patients in the present study had the opportu nity to visit the Venereal Diseases Clinic be fore the transmission of Chlamydia from ure thra to eye occurred.…”

Section: Discussioncontrasting

confidence: 57%

“…In 18 patients EIA and immunofluorescence (IF); (Syva Micro track®, Syva, Palo Alto, Calif., USA) were used in par allel, and from 11 patients samples for IF were also obtained by scraping the conjunctiva with a scalpel [3], Tears for analyzing anti-C.trachomatis antibodies were collected separately from both eyes by impregnat ing 20 mm of a Schirmer tear test strip (Cooper Vision, Pharmaceuticals Inc., P.R., USA). The strips were transferred immediately to 1.0 ml of 0.1 M phosphate buffer (pH 7.6) and stored at -2 0 °C until assayed.…”

Section: Ophthalmological Examinationmentioning

confidence: 99%

“…A part of the patients with genital chla mydial infection develops chlamydial con junctivitis [1], In addition to that, chlamydial antigen has been demonstrated on the con junctiva in 13-27% of the patients with non gonococcal urethritis but no conjunctivitis [2,3], However, in Sweden only 50-61 % of the men and 41-55% of the women with chla mydial conjunctivitis were positive in ure thral samples, too [4], In addition, among 159 patients with genital chlamydia infection at the Venereal Diseases Clinic, no conjunctival C. trachomatis was found by culture [5],…”

Section: Introductionmentioning

confidence: 99%

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Tear Anti-Chlamydia Antibodies in Males with Chlamydial Urethritis

Vaahtoranta-Lehtonen¹,

Lehtonen²,

Forsten

et al. 1993

Ophthalmic Res

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Conjunctival Chlamydia trachomatis was studied in 50 males with chlamydial urethritis. Conjunctival samples from 49 patients were negative for chlamydial antigen by enzyme immunoassay. However, tear anti-Chlamydia IgA antibodies were found in high titers (≧ 400) in 20 out of the 50 patients. Secretory IgA against Chlamydia in corresponding titers was found in 8 patients. The titers differed significantly from those of the 22 negative control subjects. IgG antibodies were not detected. Tear anti-Chlamydia IgA antibodies are not diagnostic for chlamydial conjuctivitis, but occur concomitantly in patients with chlamydial urethritis.

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Section: Discussioncontrasting

confidence: 57%

Section: Ophthalmological Examinationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Tear Anti-Chlamydia Antibodies in Males with Chlamydial Urethritis

Vaahtoranta-Lehtonen¹,

Lehtonen²,

Forsten

et al. 1993

Ophthalmic Res

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“…Identification of chlamydia trachomatis infection directly in the conjunctival smears by the use of fluorescein labelled monoclonal antibody has been shown to be more sensitive than cell culture technique [11,5,7]. In addition, it was our experience that the technique was much quicker and the procedure was simple.…”

Section: Discussionmentioning

confidence: 91%

Incidence and clinical presentation of chlamydial keratoconjunctivitis: A preliminary study

et al. 1988

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Using a direct immunofluorescent technique and monoclonal antibody, chlamydia trachomatis was detected in the conjunctival smears of 13 out of 47 patients presenting with conjunctivitis or keratoconjunctivitis (an incidence of 28%). Two patients presented with acute symptoms of few days duration, whereas the condition was chronic and of long duration in 11 patients. Conjunctival changes noted were upper and lower palpebral conjunctival follicles and papillae (11 patients), chemosis (5 patients), upper tarsal scar (2 patients) and pseudomembrane (one patient). Corneal involvement was detected in 9 patients and was manifested as micropannus (6 patients), multiple small epithelial punctate stains (3 patients), extensive pannus affecting the upper third of the cornea (2 patients), subepithelial punctate infiltrates similar to that of adenovirus infection (2 patients) and upper limbal follicles (one patient). Identification of chlamydia trachomatis in conjunctival smears by use of the monoclonal antibody is a simple, rapid and reliable laboratory procedure.

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Chlamydial Disease

Avery¹,

Baker²

2008

Albert &Amp;amp;amp Jakobiec's Principles &Amp;amp;amp Practice of Ophthalmology

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Occult chlamydial ophthalmia in men with non-gonococcal urethritis.

Cited by 3 publications

References 5 publications

Tear Anti-Chlamydia Antibodies in Males with Chlamydial Urethritis

Tear Anti-Chlamydia Antibodies in Males with Chlamydial Urethritis

Incidence and clinical presentation of chlamydial keratoconjunctivitis: A preliminary study

Chlamydial Disease

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