Occult breast carcinoma presenting with axillary lymph node metastases: follow-up of eleven patients

Matsuoka, Kinya; Ohsumi, Shozo; Takashima, Shigemitsu; Sendo, Toshiaki; Aogi, Kenjiro; Mandai, Koichi

doi:10.1007/bf02967653

Cited by 25 publications

(11 citation statements)

References 15 publications

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“…They show reactivity for gross cystic disease fluid protein‐15, estrogen receptors, progesterone receptors and CK7. The tumor cells usually lack reactivity for CK20 145 . Metastatic deposits from lobular carcinoma of the breast consist of monomorphic population of loosely cohesive malignant cells with regular nuclei, evenly distributed chromatin and inconspicuous nucleoli.…”

Section: Skin Metastases Of Carcinomasmentioning

confidence: 99%

“…The tumor cells usually lack reactivity for CK20. 145 Metastatic deposits from lobular carcinoma of the breast consist of monomorphic population of loosely cohesive malignant cells with regular nuclei, evenly distributed chromatin and inconspicuous nucleoli. The tumor cells are positive for estrogen receptors, progesterone receptors, high molecular weight cytokeratin (34 beta E12 perinuclear) and epithelial membrane antigens.…”

Section: Meningiomamentioning

confidence: 99%

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Skin metastasis: a pathologist's perspective

2010

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Skin metastasis is defined as the spread of malignant cells from a primary malignancy to the skin. It is one manifestation of systemic spread of cancer. The tumor cells originate either from an internal malignancy or from a primary skin cancer. This study presents a literature review concerning these issues as well as this author's experience encountered throughout 19 years of surgical pathology and dermatopathology practice. Several conclusions are evident. Generally, skin metastases are encountered in 0.7-9% of all patients with cancer and as such the skin is an uncommon site of metastatic disease when compared to other organs. There is usually a long-time lag between the diagnosis of the primary malignancy and the recognition of the skin metastases. However, these metastases may be the first indication of the clinically silent visceral malignancies. The regional distribution of the skin metastasis, although not always predictable, is related to the location of the primary malignancy and the mechanism of metastatic spread. The relative frequency of skin metastasis correlates with the type of primary cancer, which occurs in each sex. For instance, lung and breast carcinomas are the most common primaries that send skin metastasis in men and women, respectively. The head and neck region and the anterior chest are the areas of greatest predilection in men. The anterior chest wall and the abdomen are the most commonly involved sites in women. Skin metastases usually appear as non-specific groups of discrete firm painless nodules that emerge rapidly without any explanation. They vary in size from so tiny as to be of 'miliary lesions' to as large as 'Hen's egg size'. Some skin metastasis may mimic specific dermatological conditions such as cutaneous cyst, dermatofibroma, pyogenic granuloma, hemangioma, papular eruptions, herpes zoster eruptions, rapidly infiltrating plaques, alopecic patches, cellulitis and erysipelas. Histologically, the skin metastases usually show features reminiscent of the primary malignancy, but with variable degrees of differentiation. Molecularly, skin metastasis is an organized, non-random and organ-selective process orchestrated by interaction among several heterogeneous molecules, which are largely unknown. Metastasis to the skin is often a pre-terminal event that heralds poor outcome.

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Section: Skin Metastases Of Carcinomasmentioning

confidence: 99%

Section: Meningiomamentioning

confidence: 99%

Skin metastasis: a pathologist's perspective

2010

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“…Systemisch sollten diese Patientinnen wie typische Patientinnen mit einem nodalpositiven Mammakarzinom behandelt werden [15].…”

Section: E Nur Durch Konsequenteunclassified

“…Bei jünge-ren Patientinnen zeigen diese Verände-rungen meist ein sehr rasches Wachstum. Die histologische Klassifikation in benigne und maligne Tumoren sowie Borderline-Formen sorgt unter dem klassischen Verständnis dieser Begrifflichkeiten für Verwirrungen, denn auch die benigne Form des CP kann metastasieren, während vereinzelt maligne Formen auch einen günstigen Verlauf zeigen können [15,16]. Beim Cystosarkoma phylloides (CP) handelt es sich um eine extrem seltene neoplastische Läsion der Brustdrüse.…”

Section: Klinikunclassified

Grenzfälle des Mammakarzinoms

Mundhenke

Schem

2009

Gynäkologe

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In dieser Übersicht werden für die Phylloidestumoren wichtige Eigenheiten der Tumorentität und Empfehlungen für das klinische Management diskutiert. Bei der Betrachtung des CUP-Syndroms liegt der Schwerpunkt auf der Diskussion der zahlreichen Differentialdiagnosen bzw. Ursprünge. Es werden Wege aufgezeigt, ein okkultes Mammakarzinom gezielter diagnostizieren und von nichtmammären Ursachen abgrenzen zu können.

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“…A new breast primary may be found. Historically, when mastectomy and careful pathologic sectioning have been performed, a new breast primary has been located in 33–75% of cases (6–8). This report will present data on patients where no breast primary was found on the side with the axillary metastasis in order to highlight the complexity of this clinical scenario.…”

mentioning

confidence: 99%

The Presentation of Contralateral Axillary Lymph Node Metastases from Breast Carcinoma: A Clinical Management Dilemma

Huston¹,

Pressman²,

Moore³

et al. 2007

Breast Journal

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Metastases to the contralateral axillary lymph nodes in breast cancer patients are uncommon. Involvement of the contralateral axilla is a manifestation of systemic disease (stage IV) or a regional metastasis from a new occult primary (T0N1, stage II). The uncertain laterality of the cancer responsible for these metastases complicates overall disease staging and is a management dilemma for clinicians. Seven women who developed contralateral axillary metastases (CAM), but did not have evidence of systemic disease were identified. Patient demographics, histopathologic tumor characteristics, treatment and outcome were examined. The median age was 49 years. A family history of breast cancer was present in six (86%). The initial breast cancers were located in all quadrants. They were generally hormone receptor negative, HER-2/neu overexpressing and associated with lymphovascular invasion. There was a median interval of 71 months between initial breast cancer diagnosis and CAM presentation. Surgical management of the CAM included simple excision in one (14%) and axillary lymph node dissection in five (71%). Adjuvant treatment consisted of chemotherapy in seven (100%) and hormonal therapy in one (14%). The median follow-up from the diagnosis of CAM was 35 months and three women were alive without disease, two were alive with disease and two had died of disease. With surgical treatment, there were no axillary recurrences in this series. When patients present with CAM and no evidence of systemic disease or a new primary in the contralateral breast, surgical treatment should be considered for local control and possibly improved relapse-free survival.

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Occult breast carcinoma presenting with axillary lymph node metastases: follow-up of eleven patients

Cited by 25 publications

References 15 publications

Skin metastasis: a pathologist's perspective

Skin metastasis: a pathologist's perspective

Grenzfälle des Mammakarzinoms

The Presentation of Contralateral Axillary Lymph Node Metastases from Breast Carcinoma: A Clinical Management Dilemma

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