Occult breast cancer metastasis to the thyroid gland: Case report

Gharib, Masoumeh; Nosrati, Fatimah; Vedad, Parisa

doi:10.1002/ccr3.5998

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…Breast cancer tissue in OBC is diagnosed primarily by biopsy of lymph nodes, such as the axillary lymph nodes [5]. Conversely, several cases of OBC have been diagnosed by examining distant metastatic lesions, such as those of the thyroid gland, skin, and bone [13][14][15]. In the current case, postoperative MRI and PET/CT confirmed the absence of breast lesions, and the adenocarcinoma tissues resected using diagnostic laparoscopy were strongly consistent with breast cancer.…”

Section: Discussionmentioning

confidence: 52%

A Case Report of Occult Breast Cancer Detected by Diagnostic Laparoscopy for Suspected Ovarian Cancer

Egami,

Tarumi,

Okamura

et al. 2024

Case Reports in Obstetrics and Gynecology

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Diagnostic laparoscopy is useful in the management of gynecological cancers; however, it can occasionally result in the detection of other malignancies. Occult breast cancer (OBC) is metastatic breast cancer without a recognized primary breast lesion. We report a rare case of OBC that was detected laparoscopically. A 64-year-old female presented to our hospital with back pain. Magnetic resonance imaging (MRI) revealed a 50 mm multicystic tumor with an internal nodule in the right ovary. Positron emission tomography/computed tomography showed abnormal accumulation in multiple lymph nodes, moderate accumulation in the ovarian tumor nodule, and no accumulation in the breasts. Ovarian cancer was suspected, and a diagnostic laparoscopy was performed. Laparoscopically, a cystic tumor in the right ovary and 10 mm nodule in the right round ligament were observed and partially resected. Immunohistopathologically, the nodules of the round ligament exhibited features consistent with those of breast cancer, but the ovarian tumor was a seromucinous borderline tumor. MRI revealed no breast lesions. Therefore, the malignancy was diagnosed as an OBC.

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Section: Discussionmentioning

confidence: 52%

A Case Report of Occult Breast Cancer Detected by Diagnostic Laparoscopy for Suspected Ovarian Cancer

Egami,

Tarumi,

Okamura

et al. 2024

Case Reports in Obstetrics and Gynecology

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“…The vast majority of TMs are metachronous [ 20 ], detected after a mean time of 2.3 years in head and neck cancers [ 10 , 21 ], a mean time of 9.4 years in renal cell carcinoma [ 22 ], and even after 21 years in intestinal neuroendocrine tumors [ 23 ]. In our literature review, we found 38 papers published between 2000 and the end of January 2023 that satisfied our search criteria, consisting of 58 cases of TM that originated from BC [ 5 , 9 , 11 , 17 , 18 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ]. We summarized the cases in Table 2 .…”

Section: Current Knowledgementioning

confidence: 99%

Thyroid Metastasis from Primary Breast Cancer

Patrizio

Ferrari

Stoppini

et al. 2023

JCM

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Breast cancer (BC), the most commonly diagnosed malignancy, frequently metastasizes to the bone, lungs, brain and liver at advanced stages, whereas the thyroid gland represents a rare target site for secondary disease. We examined the most recent literature about thyroid metastasis (TM) from BC after we encountered a peculiar case of a 71-year-old woman who developed sudden dysphagia, severe hypothyroidism and hypoparathyroidism due to TM 18 years after the diagnosis of her primary cancer. Based on published data, the prevalence of TM in BC ranges from 3% to 34%, with a median onset time of 48.2 months, although longer time intervals are not infrequent. TM negatively impacts the prognosis of these patients, however thyroid surgery can limit the local disease burden. Therefore, we suggest that clinicians involved in the follow-up care of BC patients should consider a differential diagnosis of secondary thyroid malignancy when incidental lesions are diagnosed during radiological evaluations or local symptoms affect the cervical region, even many years after the diagnosis of the primary cancer.

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Occult breast cancer metastasis to the thyroid gland: Case report

Cited by 2 publications

References 11 publications

A Case Report of Occult Breast Cancer Detected by Diagnostic Laparoscopy for Suspected Ovarian Cancer

A Case Report of Occult Breast Cancer Detected by Diagnostic Laparoscopy for Suspected Ovarian Cancer

Thyroid Metastasis from Primary Breast Cancer

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