Occult Adenocarcinoma Metastatic to a Skin Graft Donor Site

Grenier, Dana Jo; Kaplan, Richard P.

doi:10.1111/j.1524-4725.1985.tb03099.x

Cited by 7 publications

(3 citation statements)

References 27 publications

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“…Malignant melanoma has been reported to show growth in the donor site of the skin graft by McEwan and Buchanon [21] and by McLean and Boorman [22]. Adenocarcinoma metastatic to a skin graft donor site was reported by Grenier and Kaplan [23].…”

Section: Discussionmentioning

confidence: 96%

Squamous cell carcinoma of the skin in both palms, axillary node, donor skin graft site and both soles—associated hyperkeratosis and porokeratosis

Abadir

Zurowski²

1994

The British Journal of Radiology

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A 74-year-old woman presented with skin squamous cell carcinomas on both palms, ankles and soles. The patient also had biopsy-proven porokeratosis. There was hyperkeratosis of the palms and soles. The left palm cancer was excised and skin grafted, but recurred. A nodule in the scar of the donor site of the skin graft in the left upper arm was biopsy-proven squamous cell carcinoma. A metastatic left axillary lymph node was excised. There were no palpable metastatic lymph nodes in either the groin or right axilla. All cancers were irradiated and disappeared, as did the incidentally irradiated hyperkeratosis. Porokeratosis may be associated with skin squamous cell carcinoma, yet in this case porokeratosis could not be identified in the heavily hyperkeratotic palms and soles. Despite poor prognostic signs, i.e. the location in the palm, and metastasis, the patient has done well so far.

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Section: Discussionmentioning

confidence: 96%

Squamous cell carcinoma of the skin in both palms, axillary node, donor skin graft site and both soles—associated hyperkeratosis and porokeratosis

Abadir

Zurowski²

1994

The British Journal of Radiology

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“…With disease progression, multiple lesions appeared near the site of the primary tumor, whereas no other cutaneous metastases developed, except those confined to the skin graft donor site. In the literature, one case of adenocarcinoma and one of angiosarcoma have also been reported as having a cutaneous localization arising in the skin graft donor site; both of them evolved in an aggressive way 6,7 …”

Section: Discussionmentioning

confidence: 99%

“…Much rarer are metastases confined to a skin graft donor site. Only four cases of melanoma have been described, 2–5 and reports of other cancer histotypes are exceptionally rare 6,7 …”

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confidence: 99%

Cutaneous Melanoma Metastases Arising on a Split-Skin Graft Donor Site

Marenco

Fava

Macripò

et al. 2009

Dermatologic Surgery

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The authors have indicated no significant interest with commercial supporters.C utaneous metastases are a frequent event in the clinical course of malignant melanoma, accounting for more than 40% of the metastatic sites. 1 Skin involvement can represent an early and a late phase of melanoma progression and can occur as a loco-regional recurrence or as distant metastases.Not uncommonly, cutaneous metastases arise within the recipient skin graft at the site of the primary melanoma. Much rarer are metastases confined to a skin graft donor site. Only four cases of melanoma have been described, 2-5 and reports of other cancer histotypes are exceptionally rare. 6,7Here we describe a case of a patient with melanoma metastases developed in a split-thickness skin graft donor site as the first cutaneous sign of disseminated disease. Case ReportA primary ulcerated melanoma on the right supraclavicular region, 2.2 mm thick, Clark level IV, of a 40-year-old man was treated with surgical excision in July 2007. On October 2007, small multiple cutaneous metastases merging into a nodular lesion were localized on the surgical scar; a swelling of the right axillary lymph nodes was also present (Figure 1). The patient underwent radical node dissection associated with the excision of cutaneous metastases. The defect was repaired using a full-thickness skin graft (0.8 cm) taken with an electric dermatome from the patient's left thigh. The histological examination confirmed the presence of melanoma cells in the skin and in six of 30 axillary lymph nodes. One month later, multiple blackbluish papulonodular lesions, ranging from 1 to 10 mm in diameter, developed on the skin graft donor site, whereas contiguous areas were uninvolved ( Figure 2); similar lesions were also present in the supraclavicular engrafted site (Figure 3). Histological analyses confirmed the metastatic nature of the lesions. Computed tomography scan showed disseminated lung and liver involvement. Blood samples from this patient were positive for tyrosinase messenger RNA (mRNA) expression as tested using reverse transcriptase polymerase chain reaction (RT-PCR) technology. 8,9 Despite palliative chemoimmunotherapy performed with dacarbazine, cisplatin, vindesine, interleukin-2, and alpha-interferon, the patient died in 2 months. DiscussionTo our knowledge, cutaneous metastases of melanoma on a skin graft donor site have been described in four case reports. [2][3][4][5] In all of these patients, despite the unlikeness base on Breslow thickness, histotype, and site of primary melanoma, the disease

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Metastases to the Skin, Soft-Tissues and Bone

TxNxM1

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Occult Adenocarcinoma Metastatic to a Skin Graft Donor Site

Cited by 7 publications

References 27 publications

Squamous cell carcinoma of the skin in both palms, axillary node, donor skin graft site and both soles—associated hyperkeratosis and porokeratosis

Squamous cell carcinoma of the skin in both palms, axillary node, donor skin graft site and both soles—associated hyperkeratosis and porokeratosis

Cutaneous Melanoma Metastases Arising on a Split-Skin Graft Donor Site

Metastases to the Skin, Soft-Tissues and Bone

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